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Lead and execute advanced computational analyses for genomic service projects, including the application of short-read and long-read sequencing pipelines. Design custom analyses and data visualizations to answer biological questions and communicate results to customers and stakeholders.
Requires a BS or MS in Bioinformatics, Computational Biology, or a related field with at least five years of bioinformatic experience. Proficiency in Linux, Python, and NGS data analysis is essential, with a preference for commercial lab experience.
About the Role:
The Bioinformatics Research Associate III is a key driver of commercial success, working with a Genomics Research Scientist to perform routine and custom bioinformatics analyses for commissioned Service projects. The Research Associate leads and executes advanced computational analyses through the application of genomics tools, approaches, and expertise to support the customer’s goals and the success of the Services team. The role serves as a technical resource and cross-team collaborator, contributing to complex projects from analysis design to data delivery.
Key Responsibilities:
Lead the application of short-read and long-read sequencing analysis pipelines for our suite of genomic approaches (CUT&RUN, CUT&Tag, Fiber-seq, etc) used in Services projects, ensuring robustness, reproducibility, and comprehensive documentation
Design and implement custom analyses and data visualizations to answer the customer’s biological questions of interest, leveraging relevant datasets to support success.
Create slide decks summarizing the study design, computational approaches, quality control checks, and results for each project.
Act as the Genomics representative on customer-facing data delivery calls
Manage and prioritize multiple bioinformatics workflows in alignment with data delivery deadlines
Proactively identify analytical needs and technical challenges, develop strategies to resolve them, and communicate progress and outcomes to key stakeholders, including the Genomics Team, Services Project Managers, and senior leadership.
Independently curate and maintain rigorous documentation of workflows, algorithms, and results, adhering to company standards and ensuring reproducibility and compliance.
Propose new computational approaches and contribute to experimental design, including hypothesis generation, troubleshooting, and refinement of assay performance.
Develop hypotheses, troubleshooting strategies, and future opportunities independently, with limited guidance from a Research Scientist.
Actively participate in team meetings and cross-functional teams, integrating R&D, Services, commercial, and executive stakeholder feedback to drive project outcomes.
Stay current with emerging technologies and tools in bioinformatics, incorporating new methodologies where appropriate to maintain a competitive edge.
Other Research Associate-related duties and projects as required.
Prepares effective presentations for lab meetings and external communications, organizing content with goal-oriented logic flows, providing clear and precise introductions, using graphic illustrations for complex explanations, designing impactful figures, and adapting presentation pace to engage the audience effectively.
Take the lead in guiding and mentoring new and/or more junior Research Associates in analytical methods, coding best practices, project management, and experimental design.
Professionally communicate data, insights, and scientific rationale professionally and confidentially, with precision and clarity across written, verbal, and collaborative contexts.
Models company values through integrity and a high standard of performance and professionalism in daily responsibilities and team interactions.
Consistently demonstrates reliability through timely execution, proactive communication, and support of team workflows and shared goals.
Openly accepts feedback, responds constructively, and adjusts to support continuous improvement.
Credentials and Experience:
BS or MS in Bioinformatics, Computational Biology, Genetics, Molecular Biology, or related field.
Minimum of five years of bioinformatic experience.
Prior experience in a commercial lab setting is preferred.
Knowledge and Skills:
Advanced proficiency in Next Generation Sequencing data analysis experience (Linux OS/Python), including bioinformatic tools and techniques
Strong understanding of biological data interpretation, statistical analysis, and visualization
Effective scientific communication with wet- and dry-lab scientists
Adaptable and flexible to shifting priorities
Ability to work towards specific goals under minimal supervision.
Ability to gain working knowledge in new fields.
Ability to consistently meet deadlines in an organized manner.
Ability to work in a fast-paced environment.
Excellent critical thinking and troubleshooting skills.
Works equally well independently and as part of a team.
Preferred Knowledge and Skills:
Experience with long-read NGS pipelines
Experience with building custom visualizations
Experience with AWS data management and transfer
Demonstrated ability to independently drive complex projects and collaborate across teams.
Compensation & Benefits:
Competitive salary commensurate with experience.
Generous benefits package includes subsidized Health, Dental, and Vision Insurances
Company-sponsored Life & AD&D Insurance, Long-Term Disability, and Short-Term Disability
Paid vacation and sick leave
Paid parental Leave
Company paid holidays, plus 2 floating holidays and 1 mental health day
401(k) plan with company match
Professional development reimbursement
Company stock options
Travel Requirements:
Up to 5% of the time.
Direct Reports:
None
Physical Demands:
While performing the duties of the Research Associate position, the employee must be able to remain stationary for prolonged periods and move about within the office and lab. The employee must be able to operate a computer and the necessary lab equipment. The employee must be able to position themselves to move objects weighing up to 10 pounds throughout the workday.
This document does not state or imply that the above duties are the only duties to be performed by the employee in this position. Requirements represent minimum levels of knowledge, skills, and/or abilities and may change at any time, with or without notice. This document does not create an employment contract, implied or otherwise.
About EpiCypher:
EpiCypher’s mission is to lead the epigenetics field in developing high-quality products and services that accelerate chromatin science to improve and extend human life. In this mission, we hold our core values in high regard: mutual respect, fairness, commitment to excellence, customer success, scientific advancement, effective communication, integrity, and teamwork.
EpiCypher is committed to providing a work environment that is free from all forms of harassment, discrimination, and inequality. We provide equal employment opportunities to all employees and applications for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, genetic information, protected veteran status, or any other characteristic protected by law.
Empowering Epigenomic Research with Cutting-Edge Tools and Services
A pioneer in the field of epigenetics and chromatin biology, EpiCypher is a bioscience company developing transformative technologies and delivering superior products to researchers world-wide. Our technologies and products are making studies possible that were not imaginable just a few years ago. Our renowned chromatin researchers possess expertise and unique insight into chromatin biology and drug discovery that benefit our customers in ways other companies cannot. Epigenetics, the study of changes in heritable traits that occur independent of alterations in changes in the underlying DNA sequence, is an emerging and important area of biomedical research with broad impact on human health and disease.
Offices: 6 Davis Dr, Durham, North Carolina 27709, US
