Watertown, Massachusetts, United States · On-site
Our team is dedicated to the development of a broad pipeline of small molecules powered by unique chemistry insights to address a wide range of highly unmet clinical needs. Our company was created within 5AM Ventures' 4:…
Skills: PyTorch, Software Engineering, CI/CD, Machine Learning Infrastructure, Data Pipelines
Boston, Massachusetts, United States · Hybrid
About Us Every business needs to know who they’re really working with whether it’s suppliers, investors, partners, or third parties. At Xapien, we’re reinventing how organisations do that, combining speed, scale and accu…
Skills: Product Marketing, Go-To-Market Strategy, Competitive Analysis, Sales Enablement, Account-Based Marketing
Boston, Massachusetts, United States · On-site
$168k–$227k/yr
We are looking for a Software Development Engineer to join the Amazon FSx for Lustre team. Amazon FSx for Lustre is a fast-growing AWS service that provides high-performance, cost-effective, and scalable storage powered …
Skills: Software Development, System Design, Architecture, Distributed Systems, Serverless Technologies
Boston, Massachusetts, United States · On-site
$150k–$215k/yr
At WHOOP, we're on a mission to unlock human performance and healthspan. WHOOP empowers members to perform at a higher level and live longer through a deeper understanding of their bodies and daily lives. Protecting our …
Skills: Kubernetes, AWS, Terraform, CI/CD, Java
San Francisco, California, United States · On-site
Are you passionate about innovation in Generative AI and Machine Learning? Do you have the technical skills in cloud software development to support organizational capabilities at AWS? Do you enjoy collaborating on proje…
Skills: Cloud Software Development, Generative AI, Machine Learning, Solution Architecture, Technical Demonstrations
Belém, Pará, Brazil · Hybrid
Role Summary: Our Digital team is seeking an HCM Platform Specialist to serve as a subject matter expert (SME) across leading HCM platforms (e.g., Workday, UKG), supporting the end-to-end success of customer integrations…
Skills: HCM Configuration, API Integration, Benefits Administration, Workday, UKG
Boston, Massachusetts, United States · On-site
About the job About Us: iMotions is the leading software provider in the biometric research space for universities and commercial clients. Our platform allows clients to conduct research in behavior, attention, and emoti…
Skills: Business Development, Sales, Prospecting, Client Relationship Management, Salesforce
Pittsfield, Massachusetts, United States · On-site
$95k–$106k/yr
Basic Qualifications Requires a Bachelor’s degree in Mechanical Engineering, or a related Science, Engineering, Technology or Mathematics field. Also requires 5+ years of job-related experience, or a Master's degree plus…
Skills: Java, JavaFX, CSS, Linux, Windows
Carapichaima, Couva-Tabaquite-Talparo, Trinidad and Tobago · Remote OK
$90k–$221k/yr
Do you enjoy building solid internal and external relationships resulting in growth? Do you enjoy collaborating cross-functionally to deliver on common goals? About Nexis Solutions Nexis Solutions, part of LexisNexis Leg…
Skills: Enterprise B2B Sales, Strategic Account Management, Consultative Selling, Executive Engagement, Value-Based Selling
Boston, Massachusetts, United States · Remote OK
$79k–$117k/yr
Bitsight is a cyber risk management leader transforming how companies manage exposure, performance, and risk for themselves and their third parties. Companies rely on Bitsight to prioritize their cybersecurity investment…
Skills: AI Workflow Design, Customer Success Operations, Prompt Engineering, Revenue Operations, Systems Thinking
Boston, Massachusetts, United States · Remote OK
$79k–$117k/yr
Bitsight is a cyber risk management leader transforming how companies manage exposure, performance, and risk for themselves and their third parties. Companies rely on Bitsight to prioritize their cybersecurity investment…
Skills: AI Workflow Design, Prompt Engineering, Customer Success Operations, Revenue Operations, Systems Thinking
Wilmington, Massachusetts, United States · On-site
$149k–$205k/yr
Who we are With its A.I.-powered robotic technology platform, Symbotic is changing the way consumer goods move through the supply chain. Intelligent software orchestrates advanced robots in a high-density, end-to-end sys…
Skills: C#, Object-Oriented Design, Asynchronous Programming, Multithreaded Programming, Event-Driven Architecture
Waltham, Massachusetts, United States · On-site
At Evident, we deliver optical technology that pushes the limits of scientific discovery. Through advanced microscopy solutions, we help researchers and innovators illuminate the unseen. Evident supplies advanced solutio…
Skills: Master Data Management, SAP ECC, SAP S/4HANA, Data Governance, Data Architecture
Boston, Massachusetts, United States · Hybrid
Principal AI Scientist and Lead Location: Hybrid- Boston (2 days a week in our Boston Office) Status: Permanent Package: Competitive Salary, Remote/Home Working (with one-off allowance), Flexible Working, (2 Days in the …
Skills: Agentic AI Systems, LLMs, RAG Architectures, Vector Databases, Python
Boston, Massachusetts, United States · On-site
$125k–$145k/yr
About DeleteMe DeleteMe is the leader in proactive privacy protection. We help security teams reduce their human attack surface by continuously monitoring and removing exposed personal data (PII) from the open web — the …
Skills: Google Cloud Platform, OpenTofu, Terraform, Infrastructure as Code, SRE
Chelmsford, Massachusetts, United States · Hybrid
$31/hr–$40/hr
Acute Care Technology At ZOLL, we're passionate about improving patient outcomes and helping save lives. We provide innovative technologies that make a meaningful difference in people's lives. Our medical devices, softwa…
Skills: Technical Support, Data Entry, SQL, Windows Operating Systems, Networking
Boston, Massachusetts, United States · Hybrid
$72k–$92k/yr
Boston University Virtual (BUV) is a unit at Boston University focused on the creation of high-quality online degree and certificate programs. Reporting to the Assistant Vice President, Digital Architecture and Technolog…
Skills: Educational Technology, Instructional Design, Project Management, Content Management Systems, Learning Management Systems
Spencer, Massachusetts, United States · Remote OK
Job Overview: We are seeking a reliable and customer-focused Help Desk Support Specialist to provide technical assistance and support to our internal teams and external clients. In this role, you will troubleshoot, diagn…
Skills: Technical Troubleshooting, Hardware Support, Software Installation, Network Troubleshooting, Customer Service
Boston, Massachusetts, United States · On-site
DLP is broken. Too many alerts, zero context, security teams drowning in noise. Jazz flips the model - full visibility from the endpoint, AI investigators that understand your business, and real answers instead of alerts…
Skills: Messaging and Positioning, Sales Enablement, Competitive Intelligence, Analyst Relations, Customer Marketing
Boston, Massachusetts, United States · Hybrid
Drug discovery is broken. We're building the AI that fixes it; a scalable closed-loop agentic system that does the scientific reasoning and analysis end-to-end, generating traceable and verifiable predictions and decisio…
Skills: Fundraising, Strategic Positioning, Business Development, Company Building, Pharmaceutical Partnerships
Watertown, Massachusetts, United States • On-site
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Own and maintain production machine learning infrastructure to transition research models into robust, deployable tools. Collaborate with chemists and biologists to develop AI agents and data pipelines that drive scientific discovery.
Requires a degree in Computer Science, Chemistry, Physics, or Data Science with strong software engineering fundamentals and PyTorch experience. Candidates should be comfortable with undergraduate-level organic chemistry and capable of driving ambiguous projects independently.
Our team is dedicated to the development of a broad pipeline of small molecules powered by unique chemistry insights to address a wide range of highly unmet clinical needs. Our company was created within 5AM Ventures' 4:59 Initiative in 2023.
The computational team has roots from D. E. Shaw Research, one of the most rigorous computational science environments in the world. You will work directly with and learn from scientists who have operated at the frontier of computational drug discovery.
This role sits at the intersection of machine learning research and the experimental teams that rely on computational tools to drive scientific decisions. Your primary responsibility will be ensuring that cutting-edge models move from research into production—reliably, maintainably, and in forms that scientists can effectively use.
For the right candidate, this is an unusually high-impact position. The systems you build will directly influence molecule triage, experimental prioritization, and the pace of scientific discovery. At many organizations, engineers are several layers removed from scientific decision-making. At our team, that distance is effectively zero.
We value ownership, initiative, and execution. Strong performers will have opportunities to grow into areas such as machine learning research, cheminformatics, AI-driven drug discovery, or agent development. The exact trajectory is flexible and can be shaped around individual strengths and interests.
We believe great people do their best work when they're supported. That's why we offer competitive compensation, meaningful equity, comprehensive health benefits, generous time off, professional development opportunities, and the flexibility to do your best work.
In addition to base salary each role has a bonus target to share in company success as well as ownership through equity.
We also provide a full benefits package that is effective from your first day of hire that includes:
We are an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected characteristics.
5AM was founded in 2002 and pursues investments in advanced life science innovations, and seeks to be diversified across the biopharmaceutical therapeutics, and platform technologies. Within each sector, 5AM invests across multiple therapeutic areas and modalities and evaluates opportunities based on innovative platform technologies, corporate spin-offs and products with shorter development cycles. Content 5AM shares on this platform is not, and may not be relied on, in any manner, as legal, tax, investment, accounting or other advice or as an offer to sell or a solicitation of an offer to buy an interest in any private fund, special purpose or other investment vehicle sponsored by 5AM Ventures. Content 5AM shares on this platform is not an investment recommendation. For a full list of all 5AM portfolio companies, please visit: https://5amventures.com/portfolio/
Offices: 501 2nd St, San Francisco, California 94107, US · 200 Clarendon St. 45th Floor, Boston, Massachusetts 02166, US
Based on 3167 listings with disclosed salaries, most software jobs in Massachusetts pay between $100k–$220k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 3,737 open software positions in Massachusetts listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include State Street, Amazon, Bright Vision Technologies, WHOOP, RTX, among others. Browse the listings above to see every active employer.
Yes — 2243 of the 3737 open software positions offer remote or hybrid work (793 remote, 1450 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
