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Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
$131k–$207k/yr
Full-time
postgraduate degree
Medical Insurance, Dental Insurance, Vision Insurance, 401(k), Paid Holidays, Vacation
Visa sponsorship available
Posted 19d ago
~40 hrs/week
Responsibilities
The Senior Scientist will lead target identification and validation studies for chronic lung diseases using advanced human-relevant in vitro and ex vivo models. They will collaborate with multidisciplinary teams to generate mechanistic datasets and support translational biomarker discovery.
Requirements
Requires a Ph.D. in Biology, Bioengineering, or a related discipline with demonstrated expertise in respiratory biology and primary cell-based systems. Candidates must be proficient in ALI cultures, organoids, and imaging-based quantitative phenotyping.
Full job description
Job Description
The Senior Scientist will join the Respiratory Biology Discovery group and contribute to target identification, target validation, translational biology, and mechanism-of-action studies supporting early discovery programs across chronic lung diseases, including COPD, bronchiectasis, asthma, pulmonary fibrosis, and inflammatory airway disorders.
The successful candidate will leverage advanced human-relevant in vitro, ex vivo, and tissue-engineered model systems to generate mechanistic and translational datasets that inform target prioritization and therapeutic strategy. Expertise in primary airway and alveolar epithelial biology, multicellular disease models, epithelial-stromal-immune interactions, tissue remodeling, regeneration, and biomarker discovery is highly desirable. The scientist will collaborate closely with multidisciplinary teams spanning biology, bioengineering, computational biology, translational sciences, and clinical research.
Key Responsibilities:
Design experimental strategies to interrogate epithelial, stromal, vascular, and immune-cell interactions driving chronic lung disease pathogenesis.
Develop and apply disease‑relevant experimental systems, including primary airway epithelial cultures, air‑liquid interface (ALI) models, organoid systems, precision-cut lung slices (PCLS), and co-culture platforms.
Generate mechanistic datasets to investigate epithelial dysfunction, tissue remodeling, fibrosis, immune responses, and regenerative biology in chronic lung diseases.
Utilize imaging, transcriptomic, proteomic, and spatial profiling approaches to support target validation and translational hypothesis generation.
Support translational biomarker discovery and validation using patient-derived samples and multiplex biomarker platforms (Luminex, Olink, AlphaLISA).
Partner with computational biology and translational teams to integrate multi-omics datasets and identify disease-relevant pathways and biomarkers.
Support evaluation of biologics, small molecules, and emerging therapeutic modalities using human disease-relevant model systems.
Synthesize and interpret complex biological datasets to support target prioritization, mechanism-of-action studies, and portfolio decision-making.
Collaborate closely across biology, pharmacology, DMPK, and translational and clinical teams within a matrixed discovery environment
QUALIFICATIONS:
Education:
Ph.D. in Biology, Immunology, Pulmonary Biology, Bioengineering, Pharmacology, Cell Biology, Regenerative Medicine or related discipline and relevant experience
Required Experience and Skills:
Demonstrated expertise in respiratory biology and human primary cell-based systems, including airway and/or alveolar epithelial models
Strong experience with ALI cultures, organoids, co-culture systems, tissue-engineered models, organ-on-chip platforms, and/or precision-cut lung slices
Experience in target validation and translational biology within respiratory, immunology, fibrosis, regeneration, or related therapeutic areas
Expertise with imaging-based approaches including IHC, IF, ICC, confocal microscopy, high-content imaging, image analysis, and quantitative phenotyping
Ability to independently design, execute, troubleshoot, and interpret complex experimental studies
Strong scientific communication skills and ability to present findings in cross-functional settings
Preferred Experience and Skills:
Prior experience in respiratory drug discovery, fibrosis, tissue remodeling, regenerative biology, or inflammatory lung disease research
Experience with macrophage, fibroblast, epithelial, or immune-stromal co-culture systems
Experience working with patient-derived respiratory tissues and primary human lung cells
Familiarity with transcriptomic datasets including bulk RNA-seq and single-cell RNA-seq
Experience with organoid biology, human tissue-based models, or spatial biology approaches
Knowledge of translational biomarker strategies and human disease-relevant endpoints
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic/International
VISA Sponsorship:
Yes
Travel Requirements:
10%
Flexible Work Arrangements:
Not Applicable
Shift:
1st - Day
Valid Driving License:
No
Hazardous Material(s):
n/a
Job Posting End Date:
07/27/2026
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
At MSD, known as Merck & Co., Inc., Rahway, NJ, USA in the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. We aspire to be the premier research-intensive biopharmaceutical company in the world – and today, we are at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We foster a diverse and inclusive global workforce and operate responsibly every day to enable a safe, sustainable and healthy future for all people and communities. For more information, visit www.msd.com and connect with us on Facebook, Instagram, Twitter, and YouTube.
Offices: 90 E Scott Ave, Rahway, New Jersey 07065, US · 2000 Galloping Hill Road, Kenilworth, NJ 07033, US · Jalan Puteri 5/20, Puchong, Selangor 47100, MY · Clos du Lynx 5, Woluwe-Saint-Lambert, Brussels Region 1200, BE · Keilaranta 3, Espoo, Southern Finland 02150, FI
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