Pasadena, California, United States · Remote OK
$225k–$262k/yr
Introduction: Xencor is a public, clinical-stage biopharmaceutical company located in the Los Angeles area (Pasadena) and in San Diego. Our focus is developing high-potential XmAb® bispecific T-cell engagers and addi…
Skills: Population PKPD Modeling, Exposure-Response Analysis, T-cell Engagers, Immunology, Rstudio
Los Angeles, California, United States · On-site
$72/hr–$107/hr
Where You’ll Work Founded in 1955, Dignity Health - Northridge Hospital Medical Center is a 394-bed, acute care, nonprofit hospital located. Serving over 80,000 patients annually, the hospital offers a full complement of…
Skills: Medication Order Review, Pharmacokinetic Monitoring, Patient Education, Medication Therapy Management, Antimicrobial Stewardship
Carlsbad, California, United States · On-site
$93k–$172k/yr
Job Title: Hardware Engineering, Tactical Data Links Job Code: 39599 Job Location: Carlsbad, CA Schedule: 9/80 (employee's work 9 out of every 14 days - totaling 80 hours worked - and have every other Friday off) Job Des…
Skills: Schematic Capture, CAD, SPICE, ADS, Hyperlynx
Carlsbad, California, United States · On-site
Job Title: Senior Specialist, Systems Test Engineer Job code: 39707 Job Location: Carlsbad, CA Job Schedule: 9/80- employees work 9 out of 14 days- totaling 80 hours worked- and have every other Friday off L3Harris’ Comm…
Skills: Systems Integration, Verification Planning, Electromagnetic Compatibility, Troubleshooting, Compliance Matrices
Mountain View, California, United States · On-site
$188k–$275k/yr
Minimum qualifications: Bachelor's degree or equivalent practical experience. 8 years of experience in program or project management. 8 years of experience in water stewardship, or a related field. Preferred qualificatio…
Skills: Water Stewardship, Program Management, Project Management, Environmental Strategy, Watershed Health
Marina del Rey, California, United States · On-site
Make a difference every single day! Cedars-Sinai Marina del Rey Hospital and its staff aim to exceed the expectations of our patients, their families and the community with a service-oriented attitude. We seek excellence…
Skills: Radiographic Examinations, Patient Care, Fluoroscopy, C-arm Imaging, O-arm Imaging
Fremont, California, United States · Hybrid
$104k–$231k/yr
The group you’ll be a part of In the Global Products Group, we are dedicated to excellence in the design and engineering of Lam’s etch and deposition products. We drive innovation to ensure our cutting-edge solutions are…
Skills: Experimental Design, Problem Solving, Troubleshooting, Technical Communication, Product Prototyping
San Diego, California, United States · On-site
$55/hr–$60/hr
Overview HealthPro Heritage has a great PRN/Per Diem Speech Language Pathologist (SLP) opportunity in the Poway Valley area of San Diego, CA! Senior Living, Assisted Living, and Memory Care setting in the 92128 area Look…
Skills: Patient Assessment, Evidence-Based Therapy, Clinical Documentation, Interpersonal Communication, Diagnostic Tool Proficiency
San Francisco, California, United States · On-site
$268k–$336k/yr
Your Impact at LILA Lila is building a platform where AI and automation co-evolve to solve the hardest problems in medicine. Within Life Science AI (LSAI), we develop autonomous-science capabilities for cellular and tiss…
Skills: Machine Learning, Biological Reasoning, Agentic Systems, Experimental Design, Bayesian Reasoning
Fremont, California, United States · Hybrid
$125k–$270k/yr
The group you’ll be a part of In the Global Products Group, we are dedicated to excellence in the design and engineering of Lam's etch and deposition products. We drive innovation to ensure our cutting-edge solutions are…
Skills: Process Engineering, Material Science, Surface Engineering, Statistical Process Control, Design of Experiments
Fremont, California, United States · Hybrid
$104k–$231k/yr
The group you’ll be a part of In the Global Products Group, we are dedicated to excellence in the design and engineering of Lam's etch and deposition products. We drive innovation to ensure our cutting-edge solutions are…
Skills: Process engineering, Semiconductor manufacturing, Material science, Surface engineering, Statistical process control
Foster City, California, United States · On-site
$75/hr–$90/hr
Description The Clinical Trial Assistant (CTA) provides operational and administrative support to the Clinical Operations team in the execution of Sagimet’s clinical trials. This role requires a highly organized, detail-…
Skills: TMF/eTMF Management, Clinical Trial Operations, Regulatory Documentation, ICH-GCP Guidelines, Site Activation
Rancho Cucamonga, California, United States · On-site
$13/hr–$26/hr
Under the direction of the Branch Manager or Field Leader, the Mobile Examiner's primary responsibility is to provide coverage in the field ensuring that mobile exams are completed accurately and on time. Maintain a safe…
Skills: Phlebotomy, Specimen Collection, EKG, Patient Care, Interpersonal Communication
San Diego, California, United States · On-site
$13/hr–$26/hr
Under the direction of the Branch Manager or Field Leader, the Mobile Examiner's primary responsibility is to provide coverage in the field ensuring that mobile exams are completed accurately and on time. Maintain a safe…
Skills: Phlebotomy, Specimen Collection, EKG, Interpersonal Communication, Organization
Pasadena, California, United States · Remote OK
$225k–$262k/yr
Introduction: Xencor is a public, clinical-stage biopharmaceutical company located in the Los Angeles area (Pasadena) and in San Diego. Our focus is developing high-potential XmAb® bispecific T-cell engagers and addition…
Skills: Population PKPD Modeling, Exposure-Response Analysis, T-cell Engagers, Rstudio, NonMem
San Jose, California, United States · On-site
$160k–$228k/yr
In an increasingly connected world, the pandemic has highlighted just how essential telecom networks are to keeping society running. The Network Infrastructure group is at the heart of a revolution to connectivity, pushi…
Skills: Vacuum Systems, RF Systems, Mechanical Design, Electrical Troubleshooting, Data Collection
San Diego, California, United States · On-site
$90k–$120k/yr
Description Position Title: Scientist Reporting to: Associate Director, ASO Strategy Research Location: San Diego, CA 92121 Employment: Full-time Salary range: $90K - $120K n-Lorem Foundation Though n-Lorem is pioneering…
Skills: Antisense oligonucleotide, qPCR, RNA isolation, cDNA preparation, Western blot
Santa Barbara, California, United States · Hybrid
$75k–$90k/yr
Business Unit: Oxford Instruments AFM Location: Santa Barbara, CA (hybrid) Job Title: Post Doctoral Industrial Scientist Reports to: R&D Management About Oxford Instruments: Our purpose is to accelerate the breakthroughs…
Skills: Atomic Force Microscopy, Nanoscale characterization, Python, Igor, Matlab
Los Angeles County, California, United States · On-site
$125k–$147k/yr
Territory: Los Angeles Central, CA - Psychiatry Target city for territory is Los Angeles - will consider candidates who live within 40 miles of territory boundaries with access to a major airport. Territory boundaries in…
Skills: Pharmaceutical Sales, Account Management, Business Planning, Clinical Knowledge, Customer Development
Goleta, California, United States · On-site
$120k–$200k/yr
Description U.S. Citizenship Required. Ability to qualify for a US Department of Defense security clearance required. This position is in person. Toyon is seeking Algorithm Developers capable of developing advanced algor…
Skills: Signal Processing, Machine Learning, Estimation Theory, Computer Vision, Computational Imaging
Pasadena, California, United States • Remote OK
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Lead the pre-clinical and clinical investigation of PKPD, safety, and efficacy relationships for novel T-cell engagers and immune-based therapeutics. Build population models to inform dose selection, support regulatory interactions, and collaborate cross-functionally to optimize dose-escalation and RP2D decisions.
Requires a Master's degree with 10+ years of experience or a PhD with 7+ years of experience in Pharmacokinetics or a related field. Must have prior experience with T-cell engagers and proficiency in modeling software such as NonMem, Monolix, or PUMAS.
Introduction:
Xencor is a public, clinical-stage biopharmaceutical company located in the Los Angeles area (Pasadena) and in San Diego. Our focus is developing high-potential XmAb® bispecific T-cell engagers and additional engineered drug candidates that leverage our differentiated technology platforms, and we are advancing our pipeline toward clinical proof-of-concept decisions. Our goal is to create high-impact therapeutics for patients with cancer and other serious diseases. More than 20 XmAb drug candidates engineered with our technology are in clinical development, and three XmAb medicines have been marketed by partners. For more information, please visit www.xencor.com. We have an excellent opportunity for a Director, Pharmacometrics & Quantitative Medicine to join our team.
This position can be hybrid with 2 days a week onsite from either our Pasadena or San Diego office or remote with candidate available during PST working hours.
Summary:
Responsible for pre-clinical and clinical investigation of pharmacokinetic vs. pharmacodynamic, safety, efficacy and other related biomarker relationships for novel T-cell engagers and immune-based therapeutics.
Primary Responsibilities:
Education/Experience/Skills:
Position requires a Master’s degree in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Applied Mathematics, or a related discipline, plus a minimum of 10 years of related experience; a PhD with 7 years of related experience is preferred. Experience managing external service providers and CRO’s with timely delivery of clear, accurate and well-written study findings also required. Prior experience with T cell engagers is required.
Position also requires:
Occasional travel may be required, including travel between Xencor’s Pasadena and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment.
Expected Base Salary Range: $225,000 - $262,000
The actual salary will be based on the selected candidate’s qualifications, including skills, competencies, education and experience. Xencor offers a competitive total rewards package including 401k match, healthcare coverage, ESPP and a broad range of other benefits. In addition, this position will be eligible for an annual bonus and equity grant. For more information, please see https://xencor.com/careers/.
Americans with Disabilities Act (ADA) Statement
The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact [email protected].
To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.
Equal Employment Opportunity (EEO) Statement
The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.
Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.
Proteins by Design
Designing Proteins. Delivering Medicines. Antibody and protein biotherapeutics are changing the way physicians treat autoimmune diseases, asthma, and cancer. At Xencor, we apply proprietary protein engineering technologies to develop better biotherapeutics – antibodies that target new biological mechanisms and are more potent, safer and longer lasting – to improve patient outcomes and quality of life. Our XmAb antibody engineering technology dramatically augments natural antibody immune functions while maintaining over 99.5% identity to natural antibodies. This combination of new, highly potent activities while maintaining the beneficial drug features and simplicity of natural antibodies allows us to create differentiated drug candidates with potential for breakthrough performance. The XmAb® platform has resulted in a robust pipeline of antibody product candidates, including eight in human clinical trials being developed by Xencor and by pharmaceutical partners. Xencor is also discovering biologics products that improve the performance of old antibody drugs, known as biosuperiors, to benefit patients, ease compliance and help reduce costs.
Offices: 465 N Halstead St, Suite 200, Pasadena, California 91107, US · 12770 High Bluff Drive Unit 260, San Diego, CA 92130-2077, US
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