Company Overview Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or…
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$160k–$240k/yr
Full-time
bachelor degree
Annual Bonus, Restricted Stock Units
Posted 50d ago
Apply by Sep 16
~40 hrs/week
Responsibilities
Oversee day-to-day pharmacovigilance operational activities and vendor management for clinical and post-marketed products. Contribute to the preparation of global safety documents and provide safety leadership for assigned clinical studies.
Requirements
Requires a bachelor's degree in a healthcare field and at least 8 years of PV operations experience. Expert knowledge of global PV requirements, ICH guidelines, and safety databases like Argus is essential.
Full job description
Company Overview Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Responsibilities and Duties
Responsible for supporting all PV operational activities across Rhythm products in clinical development and post approval stages ensuring the delivery of high-quality safety data.
Oversee day-to-day individual case safety reports management from clinical trials and post-marketed sources in accordance with PV procedures, regulatory requirements and timelines that are supported by Rhythm PV vendors.
Actively involved in PV vendor(s) management through daily emails, monitoring Key Performance Indicators (KPIs) and metrics, periodic governance meetings, and implementation of effective Corrective and Preventative Action plans, as applicable.
Contribute to planning and preparation of key global PV documents, including but not limited to Periodic Benefit-Risk Evaluation Reports (PBRERs), Periodic Safety Update Report (PSUR), Development Safety Update Reports (DSURs), and Risk management Plans (RMPs).
Act as a PV Lead for the assigned clinical studies and support cross-functional teams’ deliverables, as applicable.
Provide input to clinical study documents, including protocols, Investigators Brochures, clinical study reports, regulatory documents/responses, and safety management plans.
Actively participate in PV team strategic planning, process improvement, audits and PV work instructions and standard operating procedures development.
Stay abreast of evolving PV regulatory landscape and industry best practices to ensure ongoing compliance and operational excellence.
Qualifications and Skills
Bachelor's degree in Medicine, Pharmacy, Nursing, Epidemiology, Biomedical Sciences, or equivalent healthcare degree.
8+ years of PV operations experience is required.
3+ years of PV operations experience in a global post-marketing setting preferred.
Expert knowledge of global PV requirements, Good Pharmacovigilance Practices, ICH Guidelines, MedDRA and proprietary safety databases (e.g. Argus).
Strong experience in PV processes for vendor oversight, individual case management, aggregate data review, aggregate reports, and audits/inspections.
Ability to navigate in a matrixed environment, motivate and influence others, and effectively interact with critical internal and external stakeholders.
Proficiency in English both written and spoken, and excellent written and verbal communication skills with the ability to interact across multiple functions worldwide.
This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs.This role may involve some travel.
The expected salary range for this position is $160,000 - $240,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.
More about Rhythm We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.
At Rhythm our core values are:
We are committed to advancing scientific understanding to improve patients’ lives
We are inspired to tackle tough challenges and have the courage to ask bold questions
We are eager to learn and adapt
We believe collaboration and ownership are foundational for our success
We value the unique contribution each individual brings to furthering our mission
Inherent in our core values is the commitment to act ethically and with integrity in all we do.
Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.
Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.
Rhythm Pharmaceuticals is a global, commercial-stage biopharmaceutical company focused on transforming the lives of patients with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause.
The Company develops medicines for previously untreatable or undertreated diseases and provides meaningful support for healthcare providers and patients and their families. In addition to commercializing its lead asset in North America, Europe and other regions, Rhythm is advancing a broad clinical development program in rare MC4R pathway diseases, as well as investigational MC4R agonists, and a preclinical suite of small molecules for the treatment of congenital hyperinsulinism.
At Rhythm, we know our work makes an important difference in the lives of patients and their families around the world. Every employee contributes to the company’s goal of discovering new treatments for rare diseases that no other company is developing. As a fast-growing company with an exciting future, we offer a collaborative environment where employees’ contributions truly matter, which is one of the many reasons we were recognized as one of The Boston Globe’s Top Places to Work in Massachusetts for 2023 and 2024.
Offices: 222 Berkeley Street, 12th Floor, Boston, MA 02116, US
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