Postdoctoral Fellow - Structural Biology and Drug Discovery
Duarte, California, United States · On-site
Entry level$10M raised
Join the forefront of groundbreaking research at City of Hope, where we are changing lives and making a meaningful impact in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and com…
Skills: Structural biology, Drug discovery, Recombinant protein expression, Protein purification, X-ray crystallography
Postdoctoral Fellow - Structural Biology and Drug Discovery
Duarte, California, United States · On-site
Entry level$10M raised
Join the forefront of groundbreaking research at City of Hope, where we are changing lives and making a meaningful impact in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and com…
Skills: Structural biology, Drug discovery, Recombinant protein expression, Protein purification, X-ray crystallography
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Full-time
postgraduate degree
Comprehensive benefits
Posted 4d ago
~40 hrs/week
Responsibilities
The postdoctoral fellow will lead recombinant protein expression, purification, and structure determination using X-ray crystallography to support structure-guided ligand design. They will collaborate across structural and chemical biology disciplines to develop first-in-class modulators for metabolic disease pathways.
Requirements
Candidates must hold a Ph.D. in life sciences, biomedical sciences, or a related discipline. Essential qualifications include prior experience in protein biochemistry and X-ray crystallography, along with a proven track record of research and publications.
Full job description
Join the forefront of groundbreaking research at City of Hope, where we are changing lives and making a meaningful impact in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are united by a shared mission: to contribute to innovative approaches that predict, prevent, and cure disease while helping shape the future of medicine through cutting-edge research.
The Dr. Jeff Perry laboratory in the Beckman Research Institute of City of Hope is seeking a highly motivated postdoctoral fellow to join a multidisciplinary drug discovery program focused on a metabolic enzyme that plays a central role in cholesterol homeostasis and bile acid synthesis, with direct implications for metabolic disease and cardiometabolic risk.
As a successful candidate, you will:
Lead efforts in recombinant protein expression and purification, and structure determination using X-ray crystallography to enable structure-guided ligand design.
Collaborate at the interface of structural biology, chemical biology, and translational therapeutics, contributing to the development of first-in-class modulators targeting a clinically relevant metabolic pathway.
Your qualifications should include:
Ph.D. in life sciences, biomedical sciences, or a related discipline is required.
Prior experience in protein biochemistry and X-ray crystallography is essential.
Experience in quantitative biophysical characterization of small-molecule binding studies such as SPR, ITC, and DSF and/or an interest in mechanism-driven drug discovery and fragment-based approaches is highly desirable.
Proven track record of successful research projects and publications.
Excellent analytical and problem-solving skills.
Effective communication and collaboration abilities.
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
City of Hope is an equal opportunity employer.
To learn more about our Comprehensive Benefits, pleaseCLICK HERE.
City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. City of Hope’s affiliated group of organizations includes Translational Genomics Research Institute and AccessHope™.
Offices: 1500 E. Duarte Road, Duarte, CA 91010, US · 44151 15th St E, Lancaster, California 93535, US · 301 W Huntington Dr, Suite 400, Arcadia, California 91007, US · 301 W Huntington Dr, Suite 120, Arcadia, California 91007, US · 400 N Pepper Ave, Colton, California 92324, US
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