Pittsburgh, Pennsylvania, United States · On-site
The Department of Bioengineering is seeking a Post Doctoral Associate to investigate how glial and neurovascular biology shapes the brain’s chronic response to perturbation. This position is funded by an NIH R01 studying…
Skills: Immunohistochemistry, Confocal Microscopy, Multiphoton Imaging, Flow Cytometry, qPCR
Media, Pennsylvania, United States · On-site
Come be our next Clinical Lab Scientist and receive a $5,000 sign-on bonus! Locations: Lankenau Medical Center and Riddle Hospital Available Shifts: Evenings and Nights Available Schedule: Full and Part-time Be on the Cu…
Skills: Specimen Processing, Test Performance, Reporting Test Results, Communication, Organization
Lansdale, Pennsylvania, United States · On-site
As an Advanced Wireless/RF Engineer here at Honeywell, you will play a critical role in designing, developing, and optimizing advanced wireless and radio frequency systems that support aerospace applications. You will le…
Skills: RF Circuit Design, Wireless Communication Protocols, Antenna Design, RF Simulation, RF Testing
Macungie, Pennsylvania, United States · On-site
SUMMARY: The Investigator is responsible to lead, conduct and document investigations relating to non-conformances and/or complaints within a GMP Pharmaceutical packaging organization. The Investigator will utilize root …
Skills: Root Cause Analysis, CAPA Design, GMP Regulations, Technical Writing, Investigation Documentation
Breinigsville, Pennsylvania, United States · On-site
$110k–$176k/yr
Please Note: 1. If you are a first time user, please create your candidate login account before you apply for a job. (Click Sign In > Create Account) 2. If you already have a Candidate Account, please Sign-In before you …
Skills: Optical Device Testing, Python, C++, C#, Multi-threaded Software
Pittsburgh, Pennsylvania, United States · On-site
Work Schedule Environmental Conditions Job Description COMPANY INFORMATION Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $42 billion. Our Mission is to enable our cus…
Skills: Product Roadmap Development, Strategic Portfolio Management, Financial Forecasting, Budgeting, Market Research
Ferguson Township, Pennsylvania, United States · On-site
Job Description SummaryWe are seeking a self-motivated Mechanical Engineer to support design-related updates across an installed base of ultrasound transducers. This role focuses on implementing mechanical design changes…
Skills: 3D CAD Modeling, SolidWorks, Creo, GD&T, Tolerance Analysis
Philadelphia, Pennsylvania, United States · On-site
University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks amo…
Skills: Pharmacy Data Entry, Prescription Processing, Medication Dispensing, Payment Processing, Inventory Management
Rahway, New Jersey, United States · On-site
$173k–$273k/yr
Job Description Under minimal guidance from the Senior Director, Business Development, the incumbent is responsible for representing Regulatory Affairs on business development transactions from deal initiation through po…
Skills: Adaptability, Change Management, Detail-Oriented, Regulatory Affairs Management, Regulatory Compliance
Macungie, Pennsylvania, United States · On-site
SUMMARY: The Investigator is responsible to lead, conduct and document investigations relating to non-conformances and/or complaints within a GMP Pharmaceutical packaging organization. The Investigator will utilize root …
Skills: Root Cause Analysis, CAPA Design, GMP Regulations, Technical Writing, Interviewing Techniques
Philadelphia, Pennsylvania, United States · Hybrid
$112k–$130k/yr
University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks amo…
Skills: Scientific Operational Leadership, Translational Research, Strategic Planning, Clinical Research, Cross-institutional Collaboration
Philadelphia, Pennsylvania, United States · Hybrid
$112k–$130k/yr
University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks amo…
Skills: Scientific Operational Leadership, Translational Research, Clinical Research, Strategic Planning, Cross-Institutional Collaboration
Philadelphia, Pennsylvania, United States · On-site
The Senior Research Biostatistician provides biostatistical collaboration and consultative services to Cancer Center investigators in the conduct analysis and publication of clinical, biological, behavioral and cancer co…
Skills: Biostatistical Analysis, Data Processing, Statistical Experimental Design, Clinical Trial Monitoring, SAS
Bethlehem, Pennsylvania, United States · On-site
St. Luke's is proud of the skills, experience and compassion of its employees. The employees of St. Luke's are our most valuable asset! Individually and together, our employees are dedicated to satisfying the mission of …
Skills: Patient Assessment, Physical Examination, Evidence-Based Medicine, Patient Education, Care Coordination
Philadelphia, Pennsylvania, United States · On-site
$118k–$156k/yr
SHIFT: Any (United States of America) Seeking Breakthrough Makers Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspi…
Skills: Patient Assessment, Clinical Practice, Neurology Care, Neurosurgical Post-operative Care, Electronic Medical Records
East Hanover Township, Pennsylvania, United States · Remote OK
$186k–$345k/yr
Job Description Summary The National Director, External Expert Engagement role is responsible for partnering and collaborating with key stakeholders to implement and execute an annual plan that includes strategies and ta…
Skills: Stakeholder Engagement, Marketing Strategies, Cross-Functional Collaboration, Product Marketing, People Management
East Hanover Township, Pennsylvania, United States · Remote OK
$186k–$345k/yr
Job Description Summary The National Director, External Expert Engagement role is responsible for partnering and collaborating with key stakeholders to implement and execute an annual plan that includes strategies and ta…
Skills: Stakeholder Engagement, Marketing Strategies, Cross-Functional Collaboration, Product Marketing, People Management
Danville, Pennsylvania, United States · On-site
Location: Geisinger Medical Center (GMC) Shift: Days (United States of America) Scheduled Weekly Hours: 24 Worker Type: Regular Exemption Status: No Job Summary: Join our team at Geisinger Medical Laboratories. You can f…
Skills: Communication, Laboratory Equipment Operation, Laboratory Results Reporting, Laboratory Services, Organizing
Allentown, Pennsylvania, United States · On-site
St. Luke's is proud of the skills, experience and compassion of its employees. The employees of St. Luke's are our most valuable asset! Individually and together, our employees are dedicated to satisfying the mission of …
Skills: Patient Assessment, Physical Examination, Evidence-Based Medicine, Patient Education, Care Coordination
Newtown, Pennsylvania, United States · Hybrid
$74k–$87k/yr
It’s great to work at a place where people are truly committed to serving our students! We’re committed to bringing passion and energy to our College. Visit our Life Page on LinkedIn to explore our dynamic campus culture…
Skills: Data Visualization, SQL, Tableau, Power BI, Data Management
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
The associate will design and execute experiments to characterize glial and neurovascular responses to CNS perturbations using imaging and molecular assays. They will also develop in vitro platforms and integrate biological data with computational modeling and electrophysiology.
A Ph.D. in neuroscience, biomedical engineering, or a related field is required, along with demonstrated research experience in glial cells or neuroinflammation. Candidates must be proficient in quantitative data analysis and have hands-on experience with molecular assays or microscopy.
The Department of Bioengineering is seeking a Post Doctoral Associate to investigate how glial and neurovascular biology shapes the brain’s chronic response to perturbation. This position is funded by an NIH R01 studying how microglia, astrocyte, oligodendrocyte health and myelination influence long-term neural circuit function, and is designed for researchers trained in glial biology, neuroimmunology, neurovascular science, or the neurobiology of disease who want to apply their expertise to mechanistic questions at the interface of glial cell biology and neural circuit function. Researchers whose training is in Alzheimer’s disease, traumatic brain injury, multiple sclerosis, Huntington’s disease, stroke, or other conditions involving neuroinflammation, demyelination, or neurovascular disruption will find that their disease-model expertise applies directly to the questions we study, where many of the same pathological cascades operate in a system that is experimentally accessible at cellular resolution.
Key Responsibilities
• Design and execute experiments characterizing microglial, astrocytic, oligodendrocytic, and neurovascular responses to chronic CNS perturbation using immunohistochemistry, confocal and multiphoton imaging, flow cytometry, and molecular assays (qPCR, Western blot, RNA-seq).
• Investigate how glial phenotypic transitions evolve over time and how they are modulated by pharmacological interventions, genetic tools, and environmental parameters.
• Characterize oligodendrocyte and myelin dynamics, including OPC proliferation, differentiation, and remyelination potential, in the context of chronic neuroinflammation.
• Develop and apply in vitro platforms (primary glial cultures, iPSC-derived microglia, co-culture systems) to model glial-neuronal-vascular interactions under controlled conditions.
• Integrate biological characterization with ongoing electrophysiology, imaging, and computational modeling efforts within the lab and across collaborative teams.
• Contribute to active manuscript projects on myelin remodeling, metabolic dysfunction, and glial coordination at the neural interface.
• Build analysis pipelines for histological, transcriptomic, and proteomic datasets using R, Python, MATLAB, or ImageJ/Fiji.
• Prepare results for peer-reviewed manuscripts, conference presentations, and grant applications.
• Mentor graduate and undergraduate trainees in experimental methods and quantitative analysis.
Job Requirements
• Ph.D. in neuroscience, neurobiology, biomedical engineering, molecular/cellular biology, immunology, physiology, or a related field.
• Demonstrated research experience studying glial cells (microglia, astrocytes, oligodendrocytes), neuroinflammation, neurovascular biology, or the tissue response to CNS injury or disease.
• Hands-on experience with at least two of the following: immunohistochemistry, confocal or multiphoton microscopy, flow cytometry, rodent surgical procedures, molecular assays (qPCR, Western blot, ELISA), or RNA-seq.
• Proficiency in quantitative data analysis using R, Python, MATLAB, or equivalent tools.
• Strong record of scientific productivity, including first-author publications in peer-reviewed journals.
Preferred
• Experience with in vivo rodent models of neuroinflammation, neurodegeneration, demyelination, traumatic brain injury, or stroke.
• Experience with iPSC-derived glial cultures or in vitro co-culture systems modeling neuro-glial interactions.
• Familiarity with transcriptomic or proteomic analysis pipelines (e.g., DESeq2, IPA, Cytoscape).
• Background in oligodendrocyte biology, myelination, or OPC dynamics.
• Interest in translational neuroscience, neural interfaces, or neurostimulation. Prior device experience is welcome but not required; training will be provided.
About the Lab
Microglia, astrocytes, and oligodendrocytes coordinate the brain’s response to injury and disease, yet the mechanisms governing their activation, communication, and long-term phenotypic trajectories remain poorly characterized in vivo. Progress has been limited in part because the perturbations studied in most disease models (amyloid accumulation, diffuse axonal injury, autoimmune demyelination) are spatially dispersed, temporally uncontrolled, and difficult to access longitudinally at cellular resolution. The B.I.O.N.I.C. Lab (bioniclab.org) at the University of Pittsburgh uses chronically implanted neural devices as a controlled, spatially defined, and longitudinally accessible perturbation model to study these glial and neurovascular responses with tools that include two-photon imaging, high-density electrophysiology, immunohistochemistry, and transcriptomics. Because the same microglial activation, astrocytic scarring, blood-brain barrier disruption, and demyelination that limit neural device longevity also drive progression in Alzheimer’s disease, traumatic brain injury, multiple sclerosis, and stroke, the biological questions are shared even though the clinical context differs. Solving them advances both the basic science of glial-neuronal-vascular coordination and the translational goal of building brain-computer interfaces and neurostimulation therapies that work reliably for years.
Collaborative Environment
The position includes opportunities for cross-training across the laboratories of Drs. Franca Cambi (VA Pittsburgh, myelin and oligodendrocyte biology), Alberto Vazquez (hemodynamic and neurovascular imaging), and collaborators in cortical circuit physiology and neurostimulation. The broader environment includes UP NExT (University of Pittsburgh Neural Engineering Cross-Translation), which bridges the Swanson School of Engineering, School of Medicine, and Dietrich School of Arts and Sciences, as well as the BRIDGE-STIM 2027 workshop series connecting researchers across institutions.
Career Development
The postdoctoral associate will gain expertise at the intersection of glial biology and neural circuit function, a niche with growing demand and few trained investigators. The position provides access to a full translational pipeline (rodent through human participants), experience with multi-PI collaborative science, and mentoring in grant writing, manuscript preparation, and scientific communication. The lab supports postdoctoral career development toward independent faculty positions, and the combination of glial biology training with neural engineering context creates a distinctive research identity that is increasingly competitive for R01-level funding.
Life Changing Medicine.
UPMC is a world-renowned, nonprofit health care provider and insurer committed to delivering exceptional, people-centered care and community services. Headquartered in Pittsburgh and affiliated with the University of Pittsburgh Schools of the Health Sciences, UPMC is shaping the future of health through clinical and technological innovation, research, and education. Dedicated to advancing the well-being of our diverse communities, we provide nearly $2 billion annually in community benefits, more than any other health system in Pennsylvania. Our 100,000 employees — including more than 5,000 physicians — care for patients across more than 40 hospitals and 800 outpatient sites in Pennsylvania, New York, and Maryland, as well as overseas. UPMC Insurance Services covers more than 4 million members, providing the highest-quality care at the most affordable price. To learn more, visit UPMC.com.
Offices: US Steel Tower, 600 Grant Street, Pittsburgh, PA 15219, US
Based on 1198 listings with disclosed salaries, most science & research jobs in Pennsylvania pay between $72k–$220k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 4,691 open science & research positions in Pennsylvania listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include UPMC, MSD, Temple Health – Temple University Health System, Jefferson Health Plans, Geisinger, among others. Browse the listings above to see every active employer.
Yes — 1060 of the 4691 open science & research positions offer remote or hybrid work (317 remote, 743 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
