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$151k–$157k/yr
Full-time
postgraduate degree
Posted 30d ago
~40 hrs/week
Responsibilities
Lead the development, optimization, and scale-up of AAV manufacturing processes using Sf9 and HEK platforms. Support late-stage CMC deliverables, including process characterization, technology transfer, and the authoring of regulatory documentation.
Requirements
Requires a Master's degree with 3-6 years of experience or a PhD with 2-4 years of experience in relevant life sciences or engineering. Hands-on experience with upstream AAV production using Sf9/baculovirus and HEK platforms is mandatory.
Full job description
Role Summary
The Senior Scientist supports development, optimization, and scale-up of AAV manufacturing processes using Sf9/baculovirus and HEK-based systems. This role contributes to early and late-stage CMC activities including process characterization, technology transfer, control strategy development, and regulatory documentation. The level of responsibility, technical leadership, and cross-functional ownership will be commensurate with experience.
\nPrimary Responsibilities
Design, execute, and lead process development and optimization studies for AAV manufacturing using Sf9 cells/baculovirus and HEK platforms.
Perform hands-on laboratory work to execute process development and optimization experiments, generate critical process data, and support technical troubleshooting.
Support and, as appropriate, define study designs to drive process optimization, scalability, robustness, and technology transfer for clinical and late-stage programs.
Collaborate with and provide technical leadership across upstream, downstream, analytical, manufacturing, and quality teams to evaluate process performance and product quality.
Support or own late-stage CMC deliverables, including process characterization, risk assessments, control strategy development, technology transfer, and validation readiness.
Author, review, and provide technical input for study protocols, technical reports, and regulatory documentation.
Support or lead troubleshooting, investigations, mentoring of junior staff, and continuous process improvement initiatives.
Required Skills and Qualifications
Master’s degree in biochemical engineering, bioprocess engineering, molecular biology, cell biology, or relevant life sciences or engineering discipline with a minimum of 6 years of relevant experience, or PhD with at least 3 years of relevant experience.
Hands-on experience with upstream AAV production using Sf9 cells/baculovirus and HEK platforms required.
Understanding of virus/viral vector properties and experience with development of upstream and downstream processes for viral vectors or gene therapy products are highly desirable.
Working knowledge of downstream processing and analytical testing preferred.
Experience supporting process optimization, characterization, and late-stage CMC activities preferred.
Demonstrated leadership in process development, cross-functional collaboration, and late-stage CMC readiness is expected.
Experience authoring and reviewing regulatory documentation preferred.
\n
$136,200 - $172,000 a year
Compensation is dependent on qualifications and experience
\n
About LEXEO
Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich’s Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.
Our work culture is a hybrid model with 2 days in the New York City office and 3 days working from home.
LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Advancing science with curative potential for both cardiovascular and APOE4 associated Alzheimer's disease areas.
Industry
Biotechnology Research
Company size
11-50 employees
Founded
2018
Headquarters
New York, New York
LinkedIn followers
17,702
Total funding
$514M
Based in New York City, Lexeo Therapeutics is a clinical-stage genetic medicines company dedicated to transforming healthcare by applying pioneering science to fundamentally change how disease is treated. Building on groundbreaking research from Weill Cornell Medicine and the University of California San Diego, Lexeo partners with preeminent institutions on the cutting edge of gene therapy research. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4 associated Alzheimer's disease programs, and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing and commercialization.
For more information, please visit www.lexeotx.com.
Offices: 345 Park Avenue South, 6th Floor, New York, New York 10010, US
Based on 2855 listings with disclosed salaries, most manufacturing jobs in New York pay between $65k–$147k per year. Individual offers vary with seniority, company size, and specialization.
How many Manufacturing jobs are open in New York right now?
There are currently 7,247 open manufacturing positions in New York listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Manufacturing roles in New York?
Companies currently hiring include Carvana, Corning Incorporated, L3Harris Technologies, GE Vernova, Ralliant, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Manufacturing jobs in New York?
Yes — 639 of the 7247 open manufacturing positions offer remote or hybrid work (151 remote, 488 hybrid).
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