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San Diego, California, United States • On-site
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Responsible for devising medicinal chemistry strategies and leading multi-disciplinary project teams to advance discovery programs. This includes supervising internal staff and external CROs to optimize lead molecules and conduct complex small molecule synthesis.
Requires a degree in Chemistry (BS, MS, or PhD) with 4 to 10+ years of industrial experience depending on the degree level. Candidates must possess advanced knowledge of organic synthesis, medicinal chemistry principles, and a proven track record of innovation through patents and publications.
Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis and uterine fibroids, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)
Leads projects and initiatives in the rapid optimization of lead molecules utilizing modern technology available to medicinal chemists such as automated synthesis and purification
Distills complicated, multidimensional data to clear hypotheses and new experimental directions
Imports new principles/concepts to develop useful new experimental approaches
Researches external intellectual property relevant to project(s) and areas of pursuit
Contributes substantively to patent and publication preparation
Responsible for designing, planning, and conducting synthesis of analog libraries as well communicates results to the project or program team
Participates in a multidisciplinary team committed to the continuous improvement of the lead optimization process as well as the expeditious identification of development compounds
Plans and manages projects. Represents Medicinal Chemistry on cross-functional teams. Maintains accountability for deliverables and progress for projects
Independently designs, plans and executes activities towards the goals of one or more Medicinal Chemistry projects to support lead generation through pre-clinical activities
Supervises laboratory work and/or lab personnel and ensures safe laboratory practices
Creates and implements novel ideas in Medicinal Chemistry
Provides effective supervision of laboratory personnel and guidance for their professional development
Builds and enhances internal and external professional relationships
Other duties as assigned
BS/BA in Chemistry and 8+ years of relevant industrial experience (10+ preferred) OR
MS/MA in Chemistry preferred and 6+ years of relevant industrial experience (8+ preferred) OR
PharmD or PhD in Chemistry preferred and 4+ years of relevant industrial experience (5+ preferred)
Advanced knowledge of any or all of the following: complex organic synthesis, parallel synthesis, data analysis, lab automation, and purification in the optimization of lead compounds
Thorough understanding of medicinal chemistry and a well-developed understanding of current literature
Excellent interpersonal skills with strong oral and written communication abilities
Excellent laboratory and productivity skills
Demonstration of cross-functional understanding related to drug development
Excellent communication skills and ability to collaborate in a matrix environment are required
Strong track record of innovation demonstrated through patents and publications is necessary
Assimilates data and research findings outside of Neurocrine for application to new scientific projects
Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas
May develop an understanding of other areas and related dependencies
Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools
Ability to work as part of and lead multiple teams
Exhibits leadership skill and ability, typically leads lower levels and/or indirect teams
Excellent computer skills
Excellent communications, problem-solving, analytical thinking skills
Sees broader picture, impact on multiple programs, teams and/or departments
Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
Excellent project management skills
#LI-LS1
Neurocrine Biosciences is an EEO/Disability/Vets employer.
We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.
The annual base salary we reasonably expect to pay is $130,800.00-$179,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
You Deserve Brave Science
Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. Review our Community Guidelines: https://bit.ly/NeurocrineLinkedInGuidelines *in collaboration with AbbVie
Offices: 6027 Edgewood Bend Ct, San Diego, California 92130, US
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