Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress dive…
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Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress dive…
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$186k–$233k/yr
Senior+
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress dive…
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$211k–$264k/yr
Full-time
postgraduate degree
Competitive cash compensation, Robust equity awards, Strong benefits, Learning and development opportunities
Posted 4d ago
~40 hrs/week
Responsibilities
The Director of Clinical Pharmacology will provide strategic technical leadership for early-stage oncology assets and author critical regulatory documents for IND and clinical milestones. They will also collaborate with cross-functional teams to design clinical pharmacology studies and guide dose selection using quantitative modeling.
Requirements
Candidates must hold a Ph.D. or Pharm.D. with at least 8 years of relevant industry experience in clinical pharmacology, specifically within small molecule oncology. Strong knowledge of regulatory requirements, DMPK, toxicology, and hands-on experience with clinical pharmacology study designs and modeling software are required.
Full job description
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
We are seeking a passionate and experienced Clinical Pharmacologist with strong early development background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.
As a member of the Early Development Clinical Pharmacology group, you will:
Provide strategic insight and technical leadership within the Clinical Pharmacology function.
Author technical reports and/or regulatory documents for major milestones of clinical development, specifically IND, EOP1 & EOP2 Briefing Documents. Participate in regulatory interactions and responses to regulatory questions.
Apply state-of-the-art quantitative modeling, including translational PK/PD, population PK, and exposure-response analyses, to guide recommended phase 2 dose/schedule (RP2Ds) selection for pivotal studies.
Work with the Discovery organization to support assets in the IND-enabling stage, including collaboration with DMPK and Toxicology groups in assessment of human start dose and assessment of the need for human DDI studies.
Work with the Clinical Development team in designing FIH study.
Design and report Clin Pharm studies such as hADME, Food-Effect and DDI studies.
Engage and work with CROs on clinical pharmacology activities.
Represent the Clinical Pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions.
Required Skills, Experience and Education:
A Ph.D. or Pharm.D (with Fellowship) with Pharmaceutical Sciences background with 8+ years of relevant industry experience in Clinical Pharmacology.
Prior experience with small molecules oncology drug development.
Familiar with FDA’s Project Optimus guidance.
Well-informed in current and emerging standards of regulatory requirements and expectations for clinical pharmacology.
Hands-on experience with WinNonlin and Clin Pharm study designs.
Strong understanding of DMPK, CMC and Toxicology and related regulatory guidance is required.
Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.
A critical thinker and passionate team player and quick learner with high energy who thrives in a dynamic and fast-paced environment.
Prior management experience.
Preferred Skills:
Prior experience interacting with FDA on dose optimization.
Hand-on experience with PBPK models.
#LI-Hybrid #LI-CT1
The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [email protected].
Base Pay Salary Range
$211,000—$264,000 USD
We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.
Revolution Medicine enables physicians to integrate personalized medicine into their practices in order to more effectively treat patients.
Our genes play an important role in determining how we respond to about 75% of prescription drugs. Scientific research has demonstrated which genes predict these responses. According to the American Medical Association (AMA), 98% of physicians agree that knowing a patient’s genetic profile would help in prescribing medications. Yet, 90% of physicians do not feel they are adequately informed about how to apply genetic testing to treatment decisions.
Our mission is to improve the quality of patient care by helping doctors determine optimal treatment strategies and more accurately predict treatment responses. Revolution Medicine has developed ScriptMatch, an analytical process that enables physicians to easily incorporate genetic testing into their practices.
Our company solves a major issue in the clinical market and addresses an emerging trend in patient-driven healthcare: having clinical results that become part of the medical record and applicable to future treatments.
How much do Management & Leadership jobs in Redwood City, CA pay?
Based on 352 listings with disclosed salaries, most management & leadership jobs in Redwood City, CA pay between $102k–$260k per year. Individual offers vary with seniority, company size, and specialization.
How many Management & Leadership jobs are open in Redwood City, CA right now?
There are currently 415 open management & leadership positions in Redwood City, CA listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Management & Leadership roles in Redwood City, CA?
Companies currently hiring include Revolution Medicine, Delinea, Corcept Therapeutics, C3 AI, Box, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Management & Leadership jobs in Redwood City, CA?
Yes — 225 of the 415 open management & leadership positions offer remote or hybrid work (44 remote, 181 hybrid).
How do I apply for Management & Leadership jobs in Redwood City, CA?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.