Senior Manager, Commercial Manufacturing, Drug Substance
Redwood City, California, United States · Hybrid
$164k–$205k/yr
Senior+
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress dive…
Skills: Drug substance manufacturing, Commercial manufacturing, Technology transfer, Process validation, GMP manufacturing
For more than 25 years, Corcept has been singularly focused on the science of cortisol, a powerful hormone that when unregulated, can play a role in a broad range of diseases. Our commercial portfolio includes treatments…
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Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress dive…
WHAT IS BOX? Box (NYSE:BOX) is the leader in Intelligent Content Management. Our platform enables organizations to fuel collaboration, manage the entire content lifecycle, secure critical content, and transform business …
Skills: Marketing operations, Salesforce CRM, Marketo, HubSpot, Data integrity
Element Science, Inc.
Manager, Cost Accounting
Redwood City, California, United States · On-site
$140k–$150k/yr
Senior$183M raised
Element Science, Inc. is a medical device and digital health company redefining how patients with heart disease are monitored and treated as they transition from the hospital to the home. Our mission is to improve outcom…
Pay: $74K/YR plus DOE The pay listed is the salaried rate for this position. A specific offer will vary based on applicant’s experience, skills, abilities, geographic location, and alignment with market data. Benefit Inf…
Skills: Team supervision, Project oversight, Staff retention, Employee development, MS Office
Sequoia Hospital - Dignity Health
Clinical Nurse Educator
Redwood City, California, United States · On-site
$63/hr–$94/hr
Senior
Where You’ll Work Founded in 1950, Dignity Health - Sequoia Hospital is a 208-bed, acute care, nonprofit hospital located in Redwood City, California. Serving over 50,000 patients annually, the hospital offers a full com…
Redwood City, California, United States · Remote OK
$130k–$162k/yr
Senior
About Delinea: Delinea is a pioneer in securing human and machine identities through intelligent, centralized authorization, empowering organizations to seamlessly govern their interactions across the modern enterprise. …
Redwood City, California, United States · Remote OK
$130k–$162k/yr
Senior
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This is a Hybrid position reporting to project site in the Greater Sacramento region and office and/or residence. Job Summary Provides construction related technical and administrative services on designated projects so …
Skills: Technical support, Construction management, Project documentation, Quantity take-offs, Estimating
Redwood City, California, United States · Remote Solely
$174k–$217k/yr
Senior
About Delinea: Delinea is a pioneer in securing human and machine identities through intelligent, centralized authorization, empowering organizations to seamlessly govern their interactions across the modern enterprise. …
Job Description Must be able to control food and labor costs. Must understand the meaning of Service! Some knowledge of management in the food industry . Must be able to be a good leader. Needs to have a flexible schedul…
Overview The Vitamin Shoppe is looking for a part-time Retail Key Holder. If you’re passionate about health and wellness, interested in becoming incredibly knowledgeable about the latest and greatest supplements, and loo…
Mountain View, California, United States · On-site
$67k–$76k/yr
Mid level
IMPORTANT NOTICE FOR INTERNAL APPLICANTS ONLY: Internal applicants MUST apply to the internal job posting through the Mattress Firm Workday system. To view the list of current internal Job Postings, type “Jobs Hub” into …
Skills: Sales management, Customer experience, Team leadership, Coaching, Merchandising
Domino's
Assistant Manager(07925) - 100 FIFTH AVE
Redwood City, California, United States · On-site
Mid level$1.3B raised
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A home is more than four walls and a roof. It is where memories are made, milestones are celebrated, and lives unfold. As our Customer Care Manager, you will play a critical role in protecting that experience long after …
Skills: Customer care, Warranty management, Residential construction, Project management, Communication
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress dive…
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress dive…
Skills: Clinical Data Management, EDC Systems, UAT, Database Lock, CDISC
Vice President, Business Development - Planning & Government Solutions
Redwood City, California, United States · Hybrid
$174k–$250k/yr
Senior+
BKF is a multi-service infrastructure consulting firm providing civil engineering, construction management, environmental, planning, and surveying services across California, the Pacific Northwest, and beyond. With offic…
WHAT IS BOX? Box (NYSE:BOX) is the leader in Intelligent Content Management. Our platform enables organizations to fuel collaboration, manage the entire content lifecycle, secure critical content, and transform business …
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$164k–$205k/yr
Full-time
bachelor degree
Competitive cash compensation, Equity awards, Health benefits, Learning and development opportunities
Posted 1d ago
~40 hrs/week
Responsibilities
The Senior Manager will provide technical and operational oversight for commercial drug substance manufacturing at external partners, including technology transfer and process validation. They will lead cross-functional initiatives to ensure supply continuity, regulatory compliance, and operational excellence across the API portfolio.
Requirements
Candidates must hold a bachelor's degree in Chemical Engineering, Chemistry, or a related scientific field with at least 8-10 years of relevant industry experience. Extensive expertise in small molecule drug substance development, GMP manufacturing, and managing external manufacturing networks is required.
Full job description
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
Revolution Medicines is seeking an experienced and strategic leader to serve as Senior Manager, Commercial Manufacturing, Drug Substance within the PDM organization. This individual will play a critical role in advancing/supporting the company’s API commercial manufacturing by providing technical and operational oversight and/or support across late-stage development, process validation, commercial manufacturing and lifecycle management for small molecule drug substances.
The successful candidate will support commercial drug substance manufacturing activities at external manufacturing partners as part of the Commercial Manufacturing group within the Drug Substance team. This role will provide support for technology transfer, supply strategy, process robustness initiatives, CPV and capacity planning while ensuring that our external partners continue to supply quality material on-time.
This individual will work cross-functionally with Process Chemistry, Quality Control, Pharmaceutical Development, Quality Assurance, Regulatory, and Supply Chain teams and will serve as a key technical leader in ensuring reliable and compliant commercial manufacturing operations across Revolution Medicines’ drug substance portfolio.
The Opportunity:
Support and oversee commercial drug substance manufacturing activities for Revolution Medicines’ API portfolio, including Process Performance Qualification (PPQ), Continued Process Verification (CPV), lifecycle management, and capacity expansion activities aligned with commercial demand forecasts.
Support the development and execution of manufacturing capacity strategies to support anticipated commercial demand.
Assess manufacturing network capabilities and constraints and lead initiatives to expand throughput, improve operational efficiency, and ensure long-term commercial supply continuity.
Proactively identify, assess, and mitigate manufacturing, supply, technical, quality, compliance, and business risks that may impact timelines, regulatory commitments, budget, capacity, or supply continuity.
Ensure any process improvements align with the established robust process characterization and control strategies.
Support identification, evaluation, selection, onboarding, and technical oversight of CDMOs and external manufacturing partners, including development of redundant supply strategies and geographic diversification to enhance supply chain resilience.
Support and/or oversee technology transfer, process familiarization, engineering runs, validation campaigns, scale-up activities, and commercial manufacturing operations at external manufacturing sites.
Write, review, and approve technical documents including protocols, batch records, development reports, validation reports, campaign summaries, investigations, and regulatory support documentation associated with commercial manufacturing.
Partner cross-functionally with Process Chemistry, Quality, Regulatory, Supply Chain, and Pharmaceutical Development teams to support regulatory submissions, inspections, launch readiness, and ongoing commercial supply.
Establish strong and collaborative relationships with CDMOs and suppliers to ensure operational excellence, technical rigor, execution reliability, and long-term strategic alignment.
Communicate effectively with cross-functional project teams and senior leadership by providing clear technical, operational, and strategic updates.
Travel domestically and internationally to CDMO and supplier sites to oversee technology transfer, validation, and commercial manufacturing activities (up to approximately 25%).
Required Skills, Experience and Education:
Bachelor’s degree in Chemical Engineering, Chemistry or a related scientific discipline with a minimum of 8-10 years of relevant industry experience.
Extensive experience in small molecule drug substance development, technology transfer, process validation, and commercial manufacturing within the pharmaceutical or biotechnology industry.
Demonstrated expertise in late-stage development, commercial process validation, commercial manufacturing, Continued Process Verification (CPV), lifecycle management, and manufacturing scale-up/capacity expansion activities.
Deep understanding of GMP manufacturing, regulatory expectations, and commercialization requirements for drug substance manufacturing.
Proven experience managing CDMOs and external manufacturing networks in support of clinical and commercial supply.
Demonstrated ability to lead complex cross-functional initiatives in fast-paced development environments.
Strong leadership, communication, organizational, and problem-solving skills with the ability to influence across technical and business functions.
Preferred Skills:
Strategic and execution-oriented leader with strong technical depth and business acumen.
Ability to balance scientific rigor, operational execution, and organizational priorities in a dynamic environment.
Collaborative leadership style with demonstrated success building and developing high-performing teams and external partnerships.
Strong sense of ownership, accountability, and commitment to operational excellence and patient impact.
#LI-CT1 #LI-Hybrid
The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [email protected].
Base Pay Salary Range
$164,000—$205,000 USD
We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.
Related keywords
Drug SubstanceAPIOncologyRAS inhibitorsGMPCDMOPPQCPVProcess ChemistryQuality ControlRegulatory AffairsSupply ChainPharmaceutical DevelopmentScale-upValidationLifecycle Management
Revolution Medicine enables physicians to integrate personalized medicine into their practices in order to more effectively treat patients.
Our genes play an important role in determining how we respond to about 75% of prescription drugs. Scientific research has demonstrated which genes predict these responses. According to the American Medical Association (AMA), 98% of physicians agree that knowing a patient’s genetic profile would help in prescribing medications. Yet, 90% of physicians do not feel they are adequately informed about how to apply genetic testing to treatment decisions.
Our mission is to improve the quality of patient care by helping doctors determine optimal treatment strategies and more accurately predict treatment responses. Revolution Medicine has developed ScriptMatch, an analytical process that enables physicians to easily incorporate genetic testing into their practices.
Our company solves a major issue in the clinical market and addresses an emerging trend in patient-driven healthcare: having clinical results that become part of the medical record and applicable to future treatments.
How much do Management & Leadership jobs in Redwood City, CA pay?
Based on 352 listings with disclosed salaries, most management & leadership jobs in Redwood City, CA pay between $102k–$260k per year. Individual offers vary with seniority, company size, and specialization.
How many Management & Leadership jobs are open in Redwood City, CA right now?
There are currently 415 open management & leadership positions in Redwood City, CA listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Management & Leadership roles in Redwood City, CA?
Companies currently hiring include Revolution Medicine, Delinea, Corcept Therapeutics, C3 AI, Box, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Management & Leadership jobs in Redwood City, CA?
Yes — 225 of the 415 open management & leadership positions offer remote or hybrid work (44 remote, 181 hybrid).
How do I apply for Management & Leadership jobs in Redwood City, CA?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.