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$158k–$180k/yr
Full-time
postgraduate degree
Incentive Compensation, Equity
Posted 24d ago
~40 hrs/week
Responsibilities
Provide molecular biology expertise to support drug discovery and advance genetic medicines from early discovery through clinical development. Lead scientific strategy for novel modalities, including technology development and the evaluation of external collaborations.
Requirements
Requires a PhD or MSc with 8+ years of relevant industry or academic experience in molecular biology. Must possess deep expertise in RNA therapeutics, gene editing, or gene expression regulation.
Full job description
CSL's organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we’re building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide.
Could you be our next Principal Scientist, Molecular Biology? The job is in our Waltham MA. This is an onsite position five days a week. You will report to the Director, Molecular Biology.
You will provide expertise in Molecular Biology to support drug discovery efforts leveraging novel modalities across CSL R&D and external collaborations. This role requires deep expertise across multiple modalities, experience working with academic and industry partners, and the ability to drive innovation and advance drug candidates from early discovery through clinical development.
You will be a highly creative and rigorous scientist with the ability to solve complex scientific problems through innovative, non-obvious approaches. In alignment with CSL’s Novel Modalities strategy, the role will contribute to advancing gene expression modulation approaches and next-generation genetic medicines, with a focus on technology development, translational applicability, and pipeline progression.
Leadership and Strategy
Contribute to scientific direction supporting CSL’s novel modalities portfolio and pipeline.
Participate in external due diligence, assessing modality suitability, technical feasibility, and risk.
Identify scientific and technology gaps and propose innovative approaches to enable program advancement.
Research and Development
Design, execute, and interpret complex experiments with high scientific rigor, creativity, and efficiency.
Advance programs from concept through preclinical development toward clinical candidates.
Apply expertise across molecular modalities (e.g., RNA-, DNA-, and gene editing–based approaches) to drive therapeutic design, optimization, and mechanistic understanding.
Develop and implement novel approaches to address complex scientific challenges and critical program needs.
Establish and scale new technologies and workflows efficiently to accelerate discovery and decision-making.
Evaluate and incorporate impactful technologies (e.g., AI-enabled design, multi-omics, advanced sequencing) to support internal and external programs.
Scientific Oversight
Serve as a subject matter expert in Molecular Biology and genetic medicines.
Provide scientific guidance and mentorship to team members and collaborators.
Ensure robust experimental design, data quality, and interpretation aligned with appropriate scientific standards.
Communicate findings, risks, and recommendations clearly to diverse audiences, including senior leadership.
Contribute to intellectual property activities through technical input and scientific insight.
Education & Qualifications
PhD or MSc with 8+ years of relevant experience in Molecular Biology or a related discipline in industry and/or academia, with demonstrated progression in scientific responsibility.
Strong track record of scientific achievement in a relevant life sciences field, ideally including high-impact publications and/or a strong patent record.
Recognized as an innovative and scientifically rigorous researcher with deep subject matter expertise.
Experience working in cross-functional and multidisciplinary environments.
Expertise in several of the following areas is required:
Next-generation sequencing (short-read and long-read) and multi-omics
Computational or AI-enabled molecular design
The expected base salary range for this position at hiring is $158,000-180,000. Please note this salary range reflects the minimum and maximum base pay that CSL expects to pay for this position at the time of this posting in MA. Individual base salary for a successful candidate is determined by qualifications, skill level, experience, competencies and other relevant factors. In addition to base salary, total compensation for this role may also include incentive compensation and equity.
About CSL Behring
CSL Behring is a global biotherapeutics leader driven by our promise to save lives. Focused on serving patients’ needs by using the latest technologies, we discover, develop and deliver innovative therapies for people living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.
CSL Behring operates one of the world’s largest plasma collection networks, CSL Plasma. Our parent company, CSL, headquartered in Melbourne, Australia, employs 32,000 people, and delivers its lifesaving therapies to people in more than 100 countries.
At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future.
CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please visit https://www.csl.com/accessibility-statement.
Related keywords
Molecular BiologyRNADNAsiRNAmRNAcircRNAsaRNAGene EditingGene TherapyNext-Generation SequencingMulti-omicsAI-enabled DesignDrug DiscoveryBiotechTranslational ApplicabilityPreclinical Development
CSL is a leading global biopharma company with a dynamic portfolio of lifesaving medicines, including those that treat haemophilia and immune deficiencies, vaccines to prevent influenza, and therapies in iron deficiency, dialysis and nephrology. Since our start in 1916, we have been driven by our promise to save lives using the latest technologies.
Today, CSL – including our businesses, CSL Behring, CSL Seqirus, and CSL Vifor – provides lifesaving products to patients in more than 100 countries and employs 29,000+ people. Our unique combination of commercial strength, R&D focus and operational excellence enables us to identify, develop and deliver innovations so our patients can live life to the fullest.
See our community guidelines: https://bit.ly/3Bs17Ra
Offices: 655 Elizabeth St, Melbourne, Victoria 3000, AU · 1020 1st Ave, King of Prussia, PA 19406, US
Complex biologicalsvaccinesplasma and plasma derived therapeuticsbiotechnologyand biopharmaHealth DiagnosticsHealth CareBiotechnologyMedical
How much do Engineering jobs in Massachusetts pay?
Based on 5918 listings with disclosed salaries, most engineering jobs in Massachusetts pay between $87k–$204k per year. Individual offers vary with seniority, company size, and specialization.
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