South San Francisco, California, United States · On-site
$86k–$159k/yr
The Opportunity We are seeking a highly motivated and collaborative Scientist 2, Neuroscience Discovery & iPSC Assay Development to advance discovery research and drug development efforts within our Neuroscience team. In…
Skills: iPSC maintenance, Cell differentiation, Molecular biology, Optical imaging, Biochemistry
Madera, California, United States · On-site
$38/hr–$60/hr
Deliver diagnostic excellence—producing high-quality mammography images with precision, compassion, and confidence while making every patient feel seen, respected, and cared for. At SimonMed, mammography is one of the mo…
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Sacramento, California, United States · Hybrid
$118k–$14k/yr
Clinical Pharmacist Department: Pharmacy Location: Sacramento (Onsite/Hybrid) Schedule: Full-Time | Exempt Compensation: $140,000 - $160,000 annually Travel: Minimal, as needed "Purpose that inspires. Impact that improve…
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El Segundo, California, United States · On-site
Mid Intelligence Management Specialist CLEARANCE REQUIRED: TS/SCI with Poly This job is located at: Los Angeles AFB, CA Education: BA/BS Experience: 6+ years Job description: The applicant will work with SSC engineers, s…
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Los Angeles, California, United States · On-site
$90k–$141k/yr
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice an…
Skills: Manufacturing supervision, cGMP compliance, Quality systems, Team leadership, Performance management
Huntsville, Alabama, United States · On-site
$182k–$277k/yr
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Skills: RF communications, Satellite communications, Systems engineering, Antenna design, Link budget analysis
Thousand Oaks, California, United States · On-site
$90k–$122k/yr
Career CategoryOperationsJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious …
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Huntsville, Alabama, United States · On-site
$91k–$139k/yr
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Skills: Finite Element Analysis, Structural analysis, Spacecraft structures, Mechanisms analysis, Classical strength analysis
Irvine, California, United States · On-site
$400k–$425k/yr
Physician | Thoracic Medical Oncologist | COHOC (Irvine Hospital) City of Hope Orange County is transforming cancer care delivery in the nation’s sixth largest county. With the 2025 opening of Orange County’s only cancer…
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Foster City, California, United States · Hybrid
$147k–$190k/yr
At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve l…
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Santa Clara, California, United States · On-site
$56k–$108k/yr
Position Title: Lecturer in English-Composition and Rhetoric Position Type: Fixed Term (Fixed Term) Salary Range: Salary range is $56,290-$107,532, depending on the number of courses assigned (5-9) and commensurate with …
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Turlock, California, United States · On-site
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Turlock, California, United States · On-site
Instructional Student Assistant Employment Opportunity JOB DESCRIPTION: ***OPEN TO CURRENT STANISLAUS STATE STUDENTS, CURRENTLY ENROLLED OR ELIGIBILE TO ENROLL ONLY*** Job title and description: Undergraduate Research As…
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San Francisco, California, United States · Hybrid
$200k–$250k/yr
Who We Are: Video is 90% of the world's data. Most of it is invisible to machines. TwelveLabs builds the intelligence layer to change that. Our multimodal AI models understand video the way humans do — across sight, soun…
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San Diego, California, United States · On-site
$150k–$160k/yr
Staff Surface Process Engineer / Surface Chemist Location: San Diego, CA Job Type: Full-Time Salary Range: $150,000 - $160,000 Position Overview We are seeking a Staff Surface Process Engineer / Surface Chemist to develo…
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San Diego County, California, United States · On-site
$53k–$84k/yr
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Los Angeles, California, United States · Hybrid
$109k–$205k/yr
We anticipate the application window for this opening will close on - 4 Aug 2026 At MiniMed, you can begin a lifelong career of exploration and innovation, while helping make a difference in the lives of people living wi…
Skills: CAPA, Quality systems, Regulatory compliance, Audit preparation, Process analysis
Los Angeles, California, United States · On-site
$25/hr–$31/hr
Schweiger is one of the leading dermatology practices in the country with over 580+ healthcare providers and over 170+ offices in New York, New Jersey, Pennsylvania, Connecticut, Florida, Illinois, Missouri, Minnesota, a…
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South San Francisco, California, United States · Hybrid
$145k–$180k/yr
Non-Solicitation Policy and Notice to Agencies and Recruiters: IDEAYA's Non-Solicitation Policy strictly prohibits agencies and recruiters from any contact and communication with IDEAYA employees, managers, and leaders t…
Skills: Executive support, Operations management, Project management, Calendar management, Budget planning
Fairfield, California, United States · On-site
$300k–$370k/yr
Yosemite Pathology Medical Group (YPMG) is a private, independent, pathologist-owned surgical pathology and cytology practice committed to delivering exceptional diagnostic services throughout California. We are seeking …
Skills: Anatomic pathology, Clinical pathology, Surgical pathology, Cytopathology, Diagnostic skills
South San Francisco, California, United States • On-site
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The scientist will generate and differentiate human iPSCs into CNS cell models to execute functional assays and support disease-relevant phenotyping. They will also manage lab operations, document experimental data, and present findings to multidisciplinary project teams.
Candidates must hold a Bachelor's degree with 6+ years of experience or a Master's degree with 4+ years of experience in iPSC and mammalian cell culture. Proficiency in CNS cell lineage differentiation and molecular biology techniques is required.
The Opportunity
We are seeking a highly motivated and collaborative Scientist 2, Neuroscience Discovery & iPSC Assay Development to advance discovery research and drug development efforts within our Neuroscience team. In this role, you will leverage human induced pluripotent stem cells (iPSCs) to generate relevant central nervous system (CNS) cell models, execute functional assays, and support disease-relevant phenotyping. You will thrive in a fast-paced, matrix environment, bringing strong scientific rigor, a proactive problem-solving mindset, and a commitment to data quality and reproducibility.
Key Responsibilities:
Perform culture, banking, and quality control of human iPSCs, and differentiate iPSCs into CNS cell lineages (neurons, glia) following established protocols.
Manage and maintain routine primary neuronal cultures to support comparative and complementary functional studies.
Design, optimize, and execute robust cell-based assays supporting neuroscience pipeline programs, implementing new technology platforms when needed.
Support genetic and pharmacological proof-of-concept studies through precise execution of experimental workflows.
Generate, analyze, and document complex experimental data with a focus on high reproducibility, maintaining accurate Electronic Lab Notebook (ELN) records.
Present scientific findings and actionable insights to multidisciplinary project teams via reports, presentations, and team discussions.
Oversee iPSC lab operations, ensuring efficient shared reagent management, equipment maintenance, and adherence to safety protocols.
Who You Are
You are a curious, detail-oriented researcher who thrives in a collaborative scientific environment and is passionate about leveraging advanced cell models to transform neuroscience discovery.
Qualifications & Experience:
Bachelor’s degree in Cell Biology, Molecular Biology, Neuroscience, or a related field with 6+ years of laboratory experience, OR a Master’s degree with 4+ years of experience in iPSC and mammalian cell culture (industry or academia).
Demonstrated technical proficiency in human iPSC maintenance, banking, quality control, and directed differentiation into CNS cell types (neurons, microglia, astrocytes, or oligodendrocytes).
Hands-on expertise in molecular biology, advanced optical imaging, biochemistry, molecular profiling, and executing plate-based or high-content imaging assays.
Strong skills in independent experimental design, organization, critical thinking, and written/verbal communication.
Preferred: Familiarity or hands-on experience with CRISPR/Cas9 gene editing, arrayed/pooled CRISPR screens, or single-cell RNA sequencing (scRNA-seq) workflows.
Preferred Qualifications
Hands-on experience with CRISPR/Cas9 editing in iPSCs (guide design, RNP/lentiviral/transfection delivery, clone isolation, and genomic validation).
Experience with arrayed or pooled CRISPR screens (library preparation, transduction, NGS sample prep).
Familiarity with single-cell RNA sequencing (scRNA-seq) workflows and data interpretation using R and/or Python.
Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of South San Francisco, CA is $85,500 to $158,700. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management. Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry ten years in a row by the Dow Jones Sustainability Indices (DJSI). For more information, please visit https://careers.roche.com Read our community guidelines here: https://www.roche.com/some-guidelines.htm #Roche #Biotechnology #Pharmaceuticals #Diagnostics #Healthcare #PersonalisedHealthcare #GreatPlaceToWork #Innovation
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