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The Senior Principal Scientist is responsible for planning and directing clinical research activities for oncology medicines across all phases of development. This includes managing study design, regulatory reporting, clinical trial monitoring, and cross-functional collaboration to support drug safety and efficacy.
Requirements
Candidates must hold an M.D. or M.D./Ph.D. degree with at least 3 years of experience in clinical medicine and drug development or biomedical research. Strong interpersonal, communication, and presentation skills are essential, with board certification in Oncology or Hematology preferred.
Full job description
Job Description
The Senior Director (Sr. Principal Scientist) has primary responsibility for the planning and directing clinical research activities involving new or marketed Oncology medicines. Our Company's Oncology medicines span all phases of clinical development (pre-clinical to post-licensure). The Director will manage the entire cycle of clinical development, including: study design, placement, monitoring, analysis, regulatory reporting, and publication.
Specifically, The Senior Director May Be Responsible For
Evaluating pre-clinical and translational work for the purpose of generating early clinical development plan and Investigational New Drug applications;
Developing of clinical development strategies for investigational or marketed Oncology drugs
Planning clinical trials (design, operational plans, settings) based on these clinical development strategies
Monitoring and managing the conduct of ongoing or new clinical trials for investigational or marketed Oncology drugs;
Analyzing and summarizing the clinical findings from studies to support decisions regarding safety and efficacy as well as new drug applications, clinical study reports, or publication; and
Participation in internal and joint internal/external research project teams relevant to the development of new compounds, and the further study of marketed compounds. In executing these duties, the
The Senior Director may:
Supervise the activities of Clinical Scientists in the execution of clinical studies
Work closely with a cross-functional group of experts in commercialization, regulatory affairs, statistics, and manufacturing to manage clinical development projects; and
Assist the Senior/Executive Director in ensuring that appropriate corporate personnel are informed of the progress of studies of our Company's and competitors' drugs and internal and external expert opinion on scientific questions relevant to his/her areas of responsibility.
The Senior Director is responsible for maintaining a strong scientific fund of knowledge by:
Maintaining awareness of scientific developments within his/her area of expertise, in terms of new scientific findings, research methodologies
Identification of scientifically and operationally strong investigators who can assist in the development of our Company's investigational and marketed drugs
Establishing communications with prominent clinical investigators in his/her particular field of interest, particularly those who will be willing and able to assist in the evaluation of our Company drugs
Attending appropriate scientific meetings to maintain his or her competency and to maintain awareness of research activities in his/her area of responsibility.
To accomplish these goals, the Senior Director may:
Author detailed development documents, presentations, budgets, and position papers for internal and external audiences
Facilitating collaborations with external researchers around the world
Travel on company business about twenty (20) percent of the time to manage future or ongoing clinical research projects.
Qualifications
Education
M.D or M.D./Ph.D.
Required
Must have experience in industry or senior faculty in academia
Minimum of 3 years of clinical medicine experience
Minimum of 3 year of industry experience in drug development or biomedical research experience in academia
Demonstrated record of scientific scholarship and achievement
A proven track record in clinical medicine and background in biomedical research is essential
Strong interpersonal skills, as well as the ability to function in a team environment are essential.
Outstanding verbal and written communication and presentation skills
Preferred
Board Certified or Eligible in Oncology (and/or Hematology)
Prior specific experience in clinical research and prior publication
Required Skills:
Breast Cancer, Clinical Development, Clinical Medicine, Clinical Research Management, Clinical Trials, Data Analysis, Decision Making, Drug Development, Ethical Standards, Oncology Research, Oncology Trials, Scientific Publications, Strategic Planning
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
25%
Flexible Work Arrangements:
Not Applicable
Shift:
Not Indicated
Valid Driving License:
No
Hazardous Material(s):
n/a
Job Posting End Date:
08/20/2026
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Related keywords
OncologyClinical ResearchDrug DevelopmentBreast CancerClinical TrialsTranslational ResearchRegulatory AffairsBiomedical ResearchClinical Study ReportsInvestigational New DrugHematologyScientific ScholarshipCross-functional LeadershipClinical Development PlanPharmacovigilanceData Analysis
At MSD, known as Merck & Co., Inc., Rahway, NJ, USA in the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. We aspire to be the premier research-intensive biopharmaceutical company in the world – and today, we are at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We foster a diverse and inclusive global workforce and operate responsibly every day to enable a safe, sustainable and healthy future for all people and communities. For more information, visit www.msd.com and connect with us on Facebook, Instagram, Twitter, and YouTube.
Offices: 90 E Scott Ave, Rahway, New Jersey 07065, US · 2000 Galloping Hill Road, Kenilworth, NJ 07033, US · Jalan Puteri 5/20, Puchong, Selangor 47100, MY · Clos du Lynx 5, Woluwe-Saint-Lambert, Brussels Region 1200, BE · Keilaranta 3, Espoo, Southern Finland 02150, FI
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Based on 2813 listings with disclosed salaries, most healthcare jobs in Pennsylvania pay between $63k–$180k per year. Individual offers vary with seniority, company size, and specialization.
How many Healthcare jobs are open in Pennsylvania right now?
There are currently 29,149 open healthcare positions in Pennsylvania listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Healthcare roles in Pennsylvania?
Companies currently hiring include UPMC, CVS Health, Temple Health – Temple University Health System, Allegheny Health Network, Geisinger, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Healthcare jobs in Pennsylvania?
Yes — 2792 of the 29149 open healthcare positions offer remote or hybrid work (975 remote, 1817 hybrid).
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Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.