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Full-time
postgraduate degree
Posted 8d ago
Apply by Oct 27
~40 hrs/week
Responsibilities
The Scientist will contribute to discovery and early development of innovative therapeutics, including antibodies and multi-specifics through protein engineering and biophysical studies. They will also collaborate with internal teams and external partners to integrate experimental data for candidate selection and optimization.
Requirements
Candidates must hold a PhD in Biochemistry, Biophysics, Immunology, or a related field with 0-2 years of relevant experience. Proficiency in combinatorial library-based technologies and high-throughput characterization assays is essential.
Full job description
Position Summary:
PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated and collaborative Scientist I, Biochemistry and Biotherapeutics to join the Biologics Platform team. The successful candidate will support discovery and early development of innovative therapeutics, including antibodies, multi-specifics, T cell engagers and cytokines. This role will focus on the discovery, characterization, and optimization of lead candidates through integrated protein engineering, biophysical and mechanism-of-action studies. The ideal candidate will bring a strong foundation in protein biochemistry with hands-on experience in phage, yeast, or mammalian display and/or AI-assisted protein design for antibody discovery and optimization. The ideal candidate is also a technical expert in evaluating biotherapeutics via SPR, BLI, ELISA, flow cytometry and immuno-assays. As a valued contributor to a growing and dynamic team, this individual will help drive our mission to develop transformative therapies for patients.
Summary of Key Responsibilities:
Contribute to pipeline program and discovery project workstreams supporting target validation, candidate selection, and lead candidate optimization
Collaborate with internal research teams, external partners, and CROs to integrate experimental data with candidate selection criteria
Prepare high-quality internal presentations, scientific reports, external publications, or conference presentations, as appropriate
Stay current with emerging advances in immuno-oncology and relevant therapeutic modalities and communicate key findings internally
Provide scientific input within project teams and support the training or mentorship of junior team members
Essential Qualifications:
PhD in Biochemistry, Biophysics, Immunology or a related scientific discipline, with 0–2 years of relevant post-PhD experience in an industry or academic research setting
Hands-on experience with antibody discovery and optimization via combinatorial library-based technologies such as phage, yeast or mammalian display
Experience with antibody, multi-specific, or other protein-based therapeutics, including formatting, production and high-throughput characterization via affinity (SPR, BLI, Carterra), epitope, developability and cellular functional assays (cytotoxicity, antibody internalization, MSD assay)
Demonstrated ability to independently advance scientific projects, collaborate cross-functionally, and communicate scientific findings clearly through written reports, presentations, publications, patents, or related scientific outputs
Proficiency with data analysis and molecular biology software, such as FlowJo, GraphPad Prism, Geneious, Snapgene, etc
Collaborative, flexible, and team-oriented mindset, with the ability to contribute effectively within a dynamic research environment
Preferred Qualifications:
Working knowledge of emerging and established protein engineering technologies such as AI/ML-based protein design and optimization (RFdiffusion, pMPNN, AlphaFold, Rosetta, MOE, structure-based rational mutagenesis, etc.)
Computational expertise in NGS data analysis.
Working knowledge of structural biology, T cell and B cell biology, cancer immunology and immuno-oncology.
At PharmaEssentia, our goal is to treat as many people with cancer as possible. That means challenging the status quo with better science that leads to better lives. By joining our team, you will not only expand your own possibilities, but you will contribute to expanding options for people with cancer.
PharmaEssentia USA Corporation, a subsidiary of PharmaEssentia Corporation (TWSE: 6446), a global biopharmaceutical innovator based in Taiwan, leveraging deep expertise and proven scientific principles to deliver new biologics in hematology, oncology, and immunology. Founded in 2003, PharmaEssentia is now expanding its global presence with operations in the U.S., Japan, China and Korea.
Offices: 35 Corporate Drive, Suite 325, Burlington, MA 01803, US · 2F-5, No. 3, Park Street, Nangang District, Taipei 115, TW · Tokyo, Tokyo 100-0000, JP · Beijing, Beijing 100000, CN · Bedford, MA 01730, US
Based on 6453 listings with disclosed salaries, most healthcare jobs in Massachusetts pay between $75k–$215k per year. Individual offers vary with seniority, company size, and specialization.
How many Healthcare jobs are open in Massachusetts right now?
There are currently 22,024 open healthcare positions in Massachusetts listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Healthcare roles in Massachusetts?
Companies currently hiring include Mass General Brigham, CVS Health, UMass Memorial Health, Anna Jaques Hospital, BOSTON MEDICAL CENTER, BOSTON, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Healthcare jobs in Massachusetts?
Yes — 3774 of the 22024 open healthcare positions offer remote or hybrid work (978 remote, 2796 hybrid).
How do I apply for Healthcare jobs in Massachusetts?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.