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$100k–$120k/yr
Full-time
bachelor degree, postgraduate degree
Posted 38d ago
~40 hrs/week
Responsibilities
Lead GMP manufacturing operations for biologics production, overseeing both upstream and downstream activities. Supervise and develop manufacturing personnel while ensuring strict adherence to cGMP regulations and production schedules.
Requirements
Requires a Bachelor's degree in a scientific discipline and 5-8 years of biopharmaceutical manufacturing experience in a GMP environment. Must have at least 2 years of leadership experience and hands-on expertise in biologics operations.
Full job description
With extensive experience in developing biologics and bioconjugates, we offer a seamless service delivered by fully integrated teams, from early discovery to commercial manufacturing.
Forward-thinking and committed, we find the best solution and use the right technologies to design, develop and manufacture your products to ensure we get vital medicines to patients quickly and safely.
We are dedicated to quality excellence. We are driven to get better treatments to market, efficiently and responsibly by reducing timelines and delivering the highest quality products and services.
We are Abzena. More than a CDMO, we are a responsible and dedicated partner that takes care of your products from concept to patient.
The Manufacturing Supervisor is responsible for leading GMP manufacturing operations supporting biologics production, including cell culture, fermentation, harvest, purification, and bulk drug substance manufacturing activities. This role provides direct supervision of manufacturing personnel, ensures compliance with current Good Manufacturing Practices (cGMP), and drives safe, efficient, and high-quality execution of manufacturing campaigns.
The supervisor serves as a key operational leader, coordinating production activities, managing shift resources, supporting technology transfer and process validation activities, and partnering with Quality, Process Sciences, Supply Chain, Facilities, and MSAT teams to achieve production objectives. This role will be dedicated to the manufacturing operations of Train 2. Train 2 is a production line going from vial thaw in initial thaw and expansion to a 500L production reactor, followed by harvest, to finishing operations in downstream.
Example Plan Shifts/Training Schedule:
First 2 weeks: 8 hour shifts, M-F
Next 1-2 months: 10 hour shifts, Mon-Thurs
After 90 days: 12 hour shifts, Thurs-Sat & Alternating Wednesdays
Schedule is subject to change based on needs.
\nResponsibilities
Manufacturing Operations Leadership
Supervise day-to-day upstream and downstream GMP manufacturing operations.
Lead production activities including media and buffer preparation, cell culture expansion, bioreactor operations, harvest, chromatography, ultrafiltration/diafiltration (UF/DF), and bulk filling activities.
Ensure manufacturing campaigns are executed according to approved batch records, SOPs, and manufacturing schedules.
Coordinate shift activities and allocate resources to meet production requirements.
Monitor manufacturing performance and address operational challenges in real time.
Drive adherence to production schedules while maintaining quality and compliance standards.
Team Leadership & Development
Supervise, coach, mentor, and develop Manufacturing Associates and Senior Manufacturing Associates.
Conduct performance evaluations and establish development plans for team members.
Facilitate onboarding and qualification of new employees.
Promote a culture of safety, teamwork, accountability, and continuous improvement.
Lead daily shift meetings, production reviews, and operational communications.
GMP Compliance & Quality
Ensure strict compliance with cGMP regulations, company procedures, and regulatory requirements.
Review and verify batch documentation for accuracy and completeness.
Support investigations, deviations, CAPAs, change controls, and quality events.
Participate in internal audits, client audits, and regulatory inspections.
Ensure proper documentation practices and data integrity standards are maintained.
Process Execution & Technical Support
Provide technical oversight for upstream and downstream operations.
Support process transfers from development to GMP manufacturing.
Assist in process validation, engineering runs, and GMP campaign readiness activities.
Collaborate with MSAT, Process Development, and Engineering teams to improve process robustness and efficiency.
Troubleshoot manufacturing and equipment-related issues.
Safety & Operational Excellence
Champion Environmental Health and Safety (EHS) compliance.
Ensure safe handling of biological materials, chemicals, and manufacturing equipment.
Lead risk assessments and support implementation of corrective actions.
Drive Lean Manufacturing and continuous improvement initiatives.
Monitor and improve key performance indicators (KPIs) including safety, right-first-time execution, batch success rate, and schedule adherence.
Cross-Functional Collaboration
Partner with Quality Assurance, Quality Control, Validation, Facilities, Engineering, Supply Chain, and Program Management teams.
Support customer visits and client-facing manufacturing discussions as required.
Ensure manufacturing readiness through effective planning and material coordination.
Qualifications
Bachelor's degree in Biotechnology, Biochemistry, Biology, Chemical Engineering, Bioprocess Engineering, or related scientific discipline. (Master's degree preferred)
5–8 years of experience in biopharmaceutical manufacturing within a GMP-regulated environment.
Minimum 2 years of leadership or supervisory experience.
Hands-on experience with both upstream and downstream biologics manufacturing operations.
Experience supporting commercial, late-stage clinical, or process validation manufacturing campaigns.
Knowledge of monoclonal antibody and recombinant protein manufacturing processes.
Physical Requirements
Ability to sit or stand for extended periods of time.
Frequently lift and or move objects at least 50 pounds in weight.
Stand/walk during the entire length of shift.
Use arms, hands and fingers to handle, feel or reach.
Ability to climb, balance, stoop, kneel, crouch, or crawl.
Visual abilities include near and far sight, color, peripheral vision, depth and ability to focus.
\n
$100,000 - $120,000 a year
\n
FLSA: Exempt
Abzena is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.
This policy applies to all employment practices within our organization, including hiring, recruiting, promotion, termination, layoff, recall, leave of absence, compensation, benefits, and training.
Abzena is the leading end-to-end bioconjugate & complex biologics CDMO+CRO, focused on rapidly moving medicines forward.
Industry
Pharmaceutical Manufacturing
Company size
501-1,000 employees
Founded
2001
Headquarters
San Diego, California
LinkedIn followers
29,854
Total funding
$139M
Abzena is the leading end-to-end bioconjugate, ADC, and complex biologics CDMO + CRO. From discovery through commercial launch, we support customers with fully integrated programs or individual services designed to de-risk and streamline the development of new treatments for patients in need. With the ability to tailor its strategy and customer experience to each project, Abzena develops and implements innovative solutions that enable biotech and biopharma companies to realize the full potential of their molecule and move medicines forward faster. The company has research, development, and cGMP facilities across locations in San Diego, CA, Bristol, PA, and Cambridge, UK.
Offices: 6325 Lusk Blvd, San Diego, California 92121, US · Babraham Research Campus, Babraham, Cambridge, Cambridgeshire CB22 3AT, GB · 360 George Patterson Blvd, Suite 101E, Bristol, PA 19007, US · 11425 Sorrento Valley Rd, San Diego, California 92121, US · 2858 Loker Ave E, Carlsbad, California 92010, US
Immunogenicity Assessment & Protein EngineeringCell Line Development to GMP ManufacturingADCs & GMP BioconjugationCustom Chemical SynthesisAnalytical and Bioassay SolutionsLinker PayloadsPre-FormulationProcess DevelopmentTechnology TransferIntegrated Drug Development and Manufacturing Programs