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If you're ready to be part of our legacy of hope and innovation, we encourage you to take the first step and explore our current job openings. Your best is waiting to be discovered. Day - 08 Hour (United States of Americ…
If you're ready to be part of our legacy of hope and innovation, we encourage you to take the first step and explore our current job openings. Your best is waiting to be discovered. Day - 08 Hour (United States of Americ…
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Full-time
bachelor degree, postgraduate degree
Posted 14d ago
~40 hrs/week
Responsibilities
The Research Associate will plan, execute, and troubleshoot in vivo mouse experiments, including complex surgeries and tissue processing. They will also analyze and present research data while maintaining detailed lab documentation in accordance with regulatory standards.
Requirements
Candidates must hold a BS with at least 2 years of relevant experience or an MS in molecular biology or neuroscience. Strong proficiency in laboratory animal handling, surgical procedures, and organizational skills is required.
Full job description
About Arc Institute
Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.
Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they're free to pursue high-risk, long-term research without commercial pressures. Arc's Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.
Our two Institute Initiatives reflect this model in action:
Virtual Cell Initiative: Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets, accelerating the path from biological insight to clinical trials.
Alzheimer's Disease Initiative: Mapping the genes, pathways, and environmental factors behind Alzheimer's disease to develop drug candidates that address root causes.
More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.
About the position
We are seeking an In Vivo Research Associate II to join the Konermann Laboratory at the Arc Institute.You will collaborate closely with experienced scientists to advance in vivo projects focused on understanding brain development.
This project builds on previous work in genome-scale CRISPR screening (Konermann et al., 2015; Biering et al., 2021; Wei et al., 2023; Roohani et al., 2025) and aims to combine modern functional genomics and neuroscience tools to investigate the molecular mechanisms underlying brain development and function. The ideal candidate will have experience in animal handling and colony management, intracerebral injections, sample processing for single-cell RNA sequencing and spatial pipelines, and imaging. This position offers an excellent opportunity for candidates considering PhD programs, as it involves participation in all stages of a research project under the guidance of an experienced scientist.
About You
You love science and learning. Whether it's a new field or a new bench technique, you stay curious and enjoy stepping outside your comfort zone.
You are detail-oriented. You're careful and diligent about documentation and good lab practice, and you like keeping things organized.
You collaborate and help others. Science is a team effort, and you take the initiative to pitch in.
You are a problem solver. Experiments rarely work the first time. You bring patience and confidence to complex technical troubleshooting.
In this position, you will
Plan, execute, analyze, and troubleshoot experiments with a high degree of independence, with continued support from the rest of the team
Perform in vivo mouse experiments, including stereotaxic surgeries, as well as IV and IP injections
Collect and process tissue, including vibratome and/or cryostat sectioning, immunostaining, and imaging
Comply with federal, Arc, and local IACUC/AAALAC regulations governing animal research
Follow Arc's standards for code of conduct, safety, and the handling of hazardous materials, biological materials, and controlled substances
Analyze and present data at subgroup meetings and seminars
Maintain an organized, detailed lab notebook
Job Requirements
BS with 2+ years of relevant experience, or MS, in molecular biology, neuroscience, or another relevant field. Relevant experience includes independent lab work during undergraduate studies
Strong experience working with laboratory animals, including handling, restraint, and procedures under an approved protocol (intracranial, IV, and IP injections, as well as perfusions)
Detail-oriented, with excellent organizational and time-management skills
Outstanding critical thinking and problem-solving skills
Strong oral and written communication skills
Highly motivated and curious, with the ability to work effectively both independently and as part of a collaborative team
Ability to work some weekends as needed (days off can be swapped for weekdays
Preferred Skills
Prior experience with cloning via Gibson assembly or Golden Gate protocols (library cloning experience is a plus)
Knowledge of and experience with NGS library preparation, particularly single-cell and spatial workflows
Computational skills (Python or R)
The base salary for this position is $75,900. This amount does not include benefits or other forms of compensation.
Arc is a full-stack institute for AI and biology research, dedicated to understanding the root causes of complex diseases.
Arc’s investigators are supported by long-term funding and freedom to pursue bold ideas. Its Technology Centers are research and development hubs focused on advancing Arc's Virtual Cell and Alzheimer's Disease Initiatives, leveraging genome engineering, multiomics, and cellular, mammalian and ML models.
Founded in 2021, Arc is an independent nonprofit organization working in close partnership with Stanford University, the University of California, Berkeley, and the University of California, San Francisco.
Offices: 3181 Porter Dr, Palo Alto, California 94304, US
Based on 992 listings with disclosed salaries, most technology jobs in Palo Alto, CA pay between $110k–$265k per year. Individual offers vary with seniority, company size, and specialization.
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