About Sail: Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail's platform combines first-in-class programmable circular RNA technology (E…
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$100k–$130k/yr
Full-time
postgraduate degree
Posted 11d ago
~40 hrs/week
Responsibilities
The Scientist I will develop, optimize, and execute bioassays to characterize biological activity and immune responses for eRNA-enabled candidates. They will also manage sample operations, maintain rigorous documentation, and collaborate with cross-functional teams to advance the platform.
Requirements
Candidates must hold an M.S. or PhD in a relevant scientific field with 2-4 years of laboratory experience. Proficiency in multiparameter flow cytometry, mammalian cell culture, and assay development principles is required.
Full job description
About Sail:
Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail's platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.
The Role:
Sail Biomedicines is seeking a motivated Scientist I to join our Preclinical and Translational Assays team. This role will develop, optimize, and execute bioassays to characterize biological activity, mechanism, and immune responses for candidates enabled by Sail’s eRNA™
This is a lab-based, onsite role with substantial hands-on experimental work, collaborative problem-solving, and close partnership with cross-functional teams. The ideal candidate brings strong experience in Automation, mammalian cell culture, multiparameter flow cytometry, serology/immunoassays, qPCR, and excellent scientific documentation. Working within the team, you will generate high-quality data, troubleshoot assays, and contribute to advancing Sail’s platform and pipeline.
Responsibilities:
Bioassay Development & Execution
Develop, optimize, and execute cell-based and immunoassay workflows and pharmacology readouts (e.g., potency/functional assays, biomarker assays, serology).
Design and build multiparameter flow cytometry panels (marker selection, antibody titrations, controls, compensation, gating strategy) for preclinical in vivo study readouts and human PBMC samples.
Develop and run serology assays (e.g., binding antibody, neutralization/surrogate neutralization where applicable, cytokine/chemokine readouts) using ELISA, MSD, or related platforms.
Qualify/validate assays as appropriate: establish accuracy/precision, sensitivity, range, robustness, and implement cross-study controls and reference standards.
Own assay readiness: generate SOPs, templates, and training materials; ensure reproducibility and knowledge transfer.
Sample Operations & Study Support
Coordinate sample receipt, accessioning, and tracking from internal studies and CRO-supported work; maintain chain-of-custody, storage conditions, and inventory.
Perform sample processing (e.g., human and NHP PBMC isolation, plasma/serum handling), ensuring consistency and biosafety compliance.
Data, Documentation & Collaboration
Analyze, interpret, and summarize data; maintain rigorous records in electronic lab notebooks (ELNs) and associated databases.
Present findings internally (lab meetings, project teams) with clear conclusions, limitations, and next steps.
Partner with cross-functional teams e.g. Immunology, Analytics, and Computational/AI teams to define assay requirements, experimental design, and data structure/metadata.
Contribute to reports, tech memos, and experiments that support IP and regulatory-facing documentation where relevant.
Manage multiple concurrent experiments while maintaining high standards for lab safety, quality, and timelines.
Required Qualifications:
M.S./PhD in Immunology, Biochemistry, Molecular Biology, Chemistry, or related field.
2–4+ years relevant laboratory experience (industry preferred).
Hands-on experience with multiparameter flow cytometry, mammalian cell culture; experience with one or more of: Automation, PBMC isolation, qPCR, ELISA/MSD, or related immunoassays.
Working knowledge of assay development principles (controls, standard curves, variability, qualification/validation concepts).
Strong experimental design and troubleshooting skills; able to optimize protocols and document changes clearly.
Excellent organization and time management; able to prioritize and execute in a fast-paced environment.
Strong written/verbal communication, including presenting data and writing concise summaries.
Self-directed, collaborative, detail-oriented; demonstrates scientific curiosity and integrity.
Preferred Qualifications:
Experience with Lab Automation including but not limited to Liquid Handlers (Hamilton, Biomek)
Experience working with non-human primate (NHP) samples and associated biosafety practices.
Basic working knowledge of biostatistics (e.g., variability, curve fitting, outlier handling, assay acceptance criteria).
Experience with FlowJo, GraphPad Prism, and Microsoft Office (Excel/PowerPoint); familiarity with ELN best practices.
Experience in a matrixed project environment supporting multiple programs.
Salary Range: $100,000 - $130,000
Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.
Sail Biomedicines is creating a new class of RNA medicines designed to instruct therapeutic activity directly inside a patient’s body and within selected cells. Sail’s platform integrates Endless RNA™ (eRNA™), targeted nanoparticle delivery, and AI-enabled design to develop medicines with optimized therapeutic performance. The company is focused on applying its platform to In Vivo CAR-T medicines for immune-mediated diseases, with the goal of bringing the curative potential of CAR-T cell therapy to substantially more patients. Sail was founded by Flagship Pioneering and is headquartered in Cambridge, Massachusetts.
Offices: 140 1st St, Cambridge, Massachusetts 02141, US
Based on 657 listings with disclosed salaries, most technology jobs in Cambridge, MA pay between $88k–$245k per year. Individual offers vary with seniority, company size, and specialization.
How many Technology jobs are open in Cambridge, MA right now?
There are currently 822 open technology positions in Cambridge, MA listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Technology roles in Cambridge, MA?
Companies currently hiring include Draper, Akamai Technologies, Lila Sciences, Harvard Division of Medical Sciences, Flagship Pioneering, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Technology jobs in Cambridge, MA?
Yes — 374 of the 822 open technology positions offer remote or hybrid work (95 remote, 279 hybrid).
How do I apply for Technology jobs in Cambridge, MA?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.