Cambridge, Massachusetts, United States · On-site
$188k–$258k/yr
ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to ac…
Skills: Distributed Systems, Workflow Orchestration, Event-Driven Architecture, AWS, Infrastructure-as-Code
Cambridge, Massachusetts, United States · On-site
$108k–$209k/yr
The Company FL105 is a privately held, early-stage company pioneering the use of artificial intelligence to transform human psychological fitness and wellbeing. We are creating a platform that empowers people to build a …
Skills: Software development, Python, AWS, Cloud infrastructure, System architecture
Cambridge, Massachusetts, United States · On-site
$120k–$193k/yr
The Company FL105 is a privately held, early-stage company pioneering the use of artificial intelligence to transform human psychological fitness and wellbeing. We are creating a platform that empowers people to build a …
Skills: Machine Learning, Reinforcement Learning From Human Feedback, Supervised Fine Tuning, Large Language Models, PyTorch
Cambridge, Massachusetts, United States · On-site
$168k–$259k/yr
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Skills: Machine Learning, Molecular Modeling, Generative Chemistry, Computational Docking, Python
Cambridge, Massachusetts, United States · On-site
$132k–$259k/yr
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Skills: Machine Learning, Quantum Chemistry, Generative Molecular Design, Python, PyTorch
Cambridge, Massachusetts, United States · On-site
Here at Humanoid, we believe in a future where robots amplify human potential. That’s why we’ve set out on a mission to build the world’s most capable, commercially-scalable, and safe humanoid robots. We’re bringing that…
Skills: Robotics, Control theory, C++, Python, Hardware-in-the-loop
Cambridge, Massachusetts, United States · Hybrid
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Cambridge, Massachusetts, United States · Hybrid
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Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes. We built a leading performance-driven network of 100+ sites across the US, Eu…
Skills: Product Management, AI Application Development, Prompt Engineering, Agent Design, Retrieval-Augmented Generation (RAG)
Cambridge, Massachusetts, United States · Hybrid
Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes. We built a leading performance-driven network of 100+ sites across the US, Eu…
Skills: Cloud Security, Incident Response, Identity And Access Management, Compliance Frameworks, Vulnerability Management
Cambridge, Massachusetts, United States · Hybrid
$112k–$129k/yr
CMT is looking for a collaborative, customer-committed, and creative Senior Technical Support Engineer to help us change the world. CMT has helped protect over 65 million drivers and prevent over 126,000 crashes worldwid…
Skills: Technical support, Troubleshooting, Customer service, Zendesk, iOS
Cambridge, Massachusetts, United States · Remote OK
$66k–$118k/yr
Do you want to expand your career in Zero Trust? Are you excited to innovate problem-solving and provide top-tier technical support? Join our We are looking for a Junior Linux Engineer to join our Cloud services team . T…
Skills: Linux Administration, Docker, Kubernetes, Ansible, System Monitoring
Cambridge, Massachusetts, United States · Hybrid
$56k–$101k/yr
Do you relish the prospect of working with the most cutting-edge technology? Would supporting the biggest global network excite you? Join our Global Network Operations Command Center Our Network Operations Command Center…
Skills: Linux, Unix, SQL, Scripting, TCP/IP
Cambridge, Massachusetts, United States · Remote OK
$101k–$181k/yr
Do you relish the opportunity to work with global brands? How would you like to evangelize our cutting-edge products to partners? Join our North America Presales team Our team works with world leading companies in every …
Skills: Presales, Channel Sales, Technical Sales, TCP/IP, DNS
Cambridge, Massachusetts, United States · On-site
$147k–$204k/yr
Minimum qualifications: Bachelor's degree or equivalent practical experience. 10 years of experience in quota-carrying cloud or software sales, or consultative account management at a B2B software company. Experience eng…
Skills: Cloud Sales, Software Sales, Account Management, Pipeline Management, Forecasting
Cambridge, Massachusetts, United States · Remote OK
$139k–$251k/yr
Are you excited to work with innovative enterprise security products? Do you want an opportunity to make a difference? Join Guardicore (now Akamai Enterprise Security Group) Guardicore (now Akamai!) is changing the way o…
Skills: Product Management, Cloud Infrastructure, Cloud Security, Network Security, Zero Trust
Cambridge, Massachusetts, United States · Hybrid
$80k–$100k/yr
UI Product Designer About Us Proton is building the AI operating system for wholesale distribution, embedded in the workflows that move nearly every physical product on the planet. Distribution is a $9 trillion industry …
Skills: UI Design, Product Design, Prototyping, Design Systems, AI-native design
Cambridge, Massachusetts, United States · On-site
$75k–$156k/yr
Overview: Draper is an independent, nonprofit research and development company headquartered in Cambridge, MA. The 2,000+ employees of Draper tackle important national challenges with a promise of delivering successful a…
Skills: Autonomy engineering, Task and motion planning, Robotics platforms, AI-based approaches, C++
Cambridge, Massachusetts, United States · Hybrid
$115k–$182k/yr
Job TitleSoftware Test Engineer Job Description Software Test Engineer The Software Test Engineer will be an integral part of an interdisciplinary, and experienced functional test team, tasked with verification of best-i…
Skills: Software Testing, C#, .NET, Automation Testing, Behavioral Driven Development
Cambridge, Massachusetts, United States · Remote OK
$160k–$287k/yr
Do you enjoy solving large-scale challenges? Would you like to impact the digital experiences of billions of people? Join our next-generation cloud platform team! As part of Akamai's Cloud Technology Group (CTG), our mis…
Skills: Product Management, Cloud Computing, SaaS, Public Sector Compliance, FedRAMP
Cambridge, Massachusetts, United States · Hybrid
$151k–$177k/yr
Senior Back End Software Engineer Location: Cambridge, MA / Hybrid (This role requires working in-office 3 days per week: Tuesday, Wednesday, and Thursday.) About us: EverQuote is a leading AI-powered growth solutions pa…
Skills: Python, Java, Go, Microservices, Docker
Cambridge, Massachusetts, United States • On-site
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Own the end-to-end development of a durable orchestration layer for long-running, multi-agent scientific workflows. Architect scalable distributed systems and define SDK abstractions to bridge AI research and production stability.
Requires a B.S. or M.S. in Computer Science or Engineering with over 10 years of experience in large-scale distributed systems. Must have deep expertise in AWS, event-driven architecture, and taking prototypes to production-grade software.
Pioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship’s integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond.
The Role
The Pioneering Intelligence group at Flagship Pioneering is building intelligent software systems that integrate agentic AI with scientific reasoning to accelerate discovery and decision-making. At the center of this effort is a new autonomous research platform. It supports autonomous AI systems that reason over complex biological problems.
We are seeking a Principal Software Engineer to own the underlying agentic platform: the durable orchestration layer on which long-running, multi-agent, multi-model scientific workflows run reliably.
This is a hands-on architect role for a senior engineer who has built and operated distributed systems at scale and wants to take agentic AI from research to production. You will set the technical foundation and standards for the platform, work shoulder-to-shoulder with AI scientists, engineers, and domain experts, and turn frontier agent patterns into reusable, dependable infrastructure.
Key Responsibilities
Own the agentic platform end to end, from research prototype to production, building the durable orchestration layer for long-running, multi-stage scientific workflows. Architect workflow orchestration, evaluation frameworks, and event-driven distributed systems that deliver scale, resilience, and reliability.
Professional Experience & Qualifications
Preferred Qualifications
Why Join Us
By joining the Agentic AI team within Flagship’s Pioneering Intelligence group, you will:
Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
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The salary range for this role is $188,000 - $257,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Intelligence currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Intelligence's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [email protected].
We are a biotechnology company that invents and builds platform companies that change the world.
Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple transformative human health and sustainability products. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures. The current Flagship ecosystem comprises over 40 companies, including Denali Therapeutics, Foghorn Therapeutics, Generate:Biomedicines, Inari, Indigo Agriculture, and Tessera Therapeutics.
Offices: 55 Cambridge Parkway, Suite 800E, Cambridge, MA 02142, US
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