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Lead and execute protein production and X-ray crystallography to elucidate molecular interactions supporting drug discovery. Collaborate with cross-functional teams to facilitate structure-based drug design and investigate novel mechanisms of action.
Requires a Ph.D. in structural biology, biophysics, or biochemistry with over 5 years of experience in X-ray crystallography. Must have demonstrated expertise in protein expression across multiple systems and a proven track record in protein-ligand complex characterization.
Internal Job Title: Principal Scientist I/II
Location: onsite, San Diego, CA #LI-Onsite
About the Role:
At Novartis, we are reimagining medicine through scientific excellence and innovation. Within the Discovery Sciences organization, the Protein Sciences group plays a pivotal role in advancing early-stage drug discovery by enabling deep structural and functional insights into therapeutic targets. Structural Biology is a cornerstone capability, enabling structure-guided drug discovery for some of the most challenging and high-impact targets in medicine.
This is a unique opportunity to join a world-class structural biology team within one of the largest and most innovative pharmaceutical companies. You’ll have access to state-of-the-art instrumentation, highly skilled and collaborative colleagues, and the chance to make meaningful contributions to the discovery and development of life-changing medicines.
Lead and execute protein production and X-ray crystallography to elucidate protein-small molecule, protein-peptide, and/or protein-protein interactions, supporting drug discovery initiatives
Successfully drive gene-to-structural small molecule drug discovery projects
Leverage knowledge in protein production and structural biology to characterize structure-function relationships, investigate novel mechanisms of action, and address complex scientific questions
Collaborate with cross-functional teams, including protein scientists, biophysicists, chemists, and computational modelers, to facilitate structure-based drug design
Advance our initiatives and drug discovery programs by leveraging innovative approaches, such as applications of AI.
Ph.D. in structural biology, biophysics, biochemistry, or a related field with over 5 years of relevant experience in X-ray crystallography within either industrial or academic settings
Demonstrated expertise in protein expression across E. coli, insect, and mammalian expression systems, as well as extensive experience in protein purification and characterization
Proven track record in application of X-ray crystallography to characterize protein-ligand and protein-protein complexes, including crystallization screening and optimization, data processing, structure refinement and analysis.
Outstanding communication skills, strong ability to collaborate within multidisciplinary teams, and ability to work in a fast-paced, goal-driven environment.
Understanding of AI/ML tools for structural biology
Experience with biochemical assays and biophysical methods
Experience with Cryo-EM is a plus
The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.
Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.
US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
To learn more about the culture, rewards and benefits we offer our people click here.
The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Novartis is an innovative medicines company. Every day, working to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide. Find out more at https://www.novartis.com See our community guidelines: https://go.novartis.social/3Nboxki
Offices: Novartis Campus, Basel, Baselstadt 4002, CH · One Health Plaza, East Hanover, NJ 07936, US · Calle 93B S-31, Bogota, Bogota, D.C. 110541, CO · Merrion Road, Dublin, County Dublin, IE · Na Pankraci 1724/129, Prague, Prague 140 00, CZ
Based on 1450 listings with disclosed salaries, most science & research jobs in San Diego, CA pay between $74k–$213k per year. Individual offers vary with seniority, company size, and specialization.
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