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$155k–$180k/yr
Full-time
postgraduate degree, bachelor degree
Bonus, Equity
Posted 21d ago
~40 hrs/week
Responsibilities
Develop and optimize antibody bioconjugation methods for degrader payloads and linkers, ensuring they are scalable and compatible with automated workflows. Execute conjugation runs and purify materials using FPLC and TFF to support pharmacology and PK/PD studies.
Requirements
Requires a PhD in chemistry or a related field, or a BS/MS with at least 8 years of industry bioconjugation experience. Must have hands-on expertise in site-specific conjugation chemistries and conjugate characterization techniques.
Full job description
About the Role
We are growing the team with a hands-on antibody conjugation scientist who will build this capability from the ground up by developing and validating bioconjugation chemistries that are reproducible at bench scale, sufficiently robust for transfer to automated higher-throughput synthesis workflows, and scalable for preparation campaigns supporting advanced in vivo and translational studies.
This is a lab-based role for someone who wants to build a new technical capability inside an established, highly collaborative discovery organization and partner closely with medicinal chemistry, analytical chemistry, computational chemistry, protein biochemistry, and automation to move candidates from bench to study-ready material.
What You'll Do
Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines.
Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise.
Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently.
Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed.
Stay current on emerging bioconjugation and DAC/ADC methodology and bring forward new techniques relevant to Nurix's pipeline.
Who You Are
A team player who works well across disciplines (chemistry, analytical, protein biochemistry, automation/engineering) and communicates clearly with both scientists and technical staff.
Results-oriented: you drive a method from first attempt to a robust, transferable protocol, and you personally deliver material when a study needs it.
Comfortable owning a technical area with real autonomy in a growing capability area.
Qualifications
PhD in chemistry, biochemistry, chemical biology, or a related field preferred; MS or BS with substantial (8+ for BS/MS) hands-on industry bioconjugation experience will also be considered.
Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.
Experience purifying and characterizing conjugates: FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis.
Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team.
Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization
Why This Role
You'll be the founding technical expert for antibody conjugation at Nurix, shaping both the science and how it's automated and scaled — with direct visibility to program leadership and a fast path from method development to real studies
Salary Range: 155K - 180K plus bonus and equity
Fit with Nurix Culture and Values
Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view
We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job within Nurix or in the course of your employment with Nurix. By applying for a position with Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/)
Related keywords
Antibody Drug ConjugatesADCDACNHS EsterMaleimide CouplingCuAACSPAACIEDDAEngineered-CysteineGlycan ConjugationUnnatural Amino AcidsHamiltonTecanBioconjugationMedicinal ChemistryAnalytical Chemistry
Nurix is writing medicine’s next chapter using targeted protein degradation as a new script to outmatch disease.
Industry
Biotechnology
Company size
201-500 employees
Founded
2012
Headquarters
Brisbane, California
LinkedIn followers
25,748
Total funding
$796M
Important Notice to Candidates: Nurix representatives with never conduct interviews by text and will never request personal financial information or ask candidates to purchase equipment.
At Nurix Therapeutics, we aim to fundamentally change the way disease is treated using degrader-based medicines. Our journey began with a vision to harness the power of the cell’s natural protein degradation machinery, the ubiquitin-proteasome system, to create a new class of therapeutics that can overcome the limitations of current treatments.
Offices: 1600 Sierra Point Pkwy, Brisbane, California 94005, US · 8800 Technology Forest Pl, Building 100, Suite 200, The Woodlands, Texas 77381, US
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