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$195k–$275k/yr
Full-time
postgraduate degree
401(k) plan, Medical insurance, Dental insurance, Vision insurance, Life insurance, Paid time off
Posted 5d ago
~40 hrs/week
Remote in United States
Responsibilities
The Senior Director will provide strategic leadership for translational clinical pharmacology across the neuroscience pipeline, from early development through registrational programs. They will drive dose selection and optimization by integrating PK, PD, and safety data while representing the company in regulatory interactions.
Requirements
Candidates must hold a PhD, PharmD, or MD in a relevant discipline with 8–12+ years of experience in clinical pharmacology within the biopharma industry. Extensive expertise in translational science, quantitative modeling, and regulatory submission processes is required.
Full job description
Description of Role
Centessa is seeking an experienced Senior Director, Clinical Pharmacology (translational) to provide scientific and strategic leadership for translational clinical pharmacology across a diverse pipeline spanning early development through late‑stage and registrational programs. Reporting to the Executive Director, Clinical Pharmacology, this position is accountable for developing and executing clinical pharmacology strategies that address the unique challenges of neuroscience drug development, including CNS exposure, dose optimization, and translational relevance. The Senior Director partners closely with cross‑functional teams, and cross-program teams to achieve broader translational understanding of our assets, and application of that knowledge to development programs. Additionally, they will represent clinical pharmacology in regulatory interactions to enable efficient, data‑driven advancement of therapies across our neuroscience portfolio.
Key Responsibilities
Lead strategy for collection and interpretation of information across in vitro, in vivo, literature of competitive sources, and clinical data to develop a translational knowledge base to Centessa assets
Drive dose selection and optimization by integrating PK, PD, safety, efficacy, and CNS‑specific biomarkers
Lead model‑informed drug development, including population PK, PK/PD, and exposure–response analyses relevant to CNS targets and clinical safety
Assess and guide strategies for CNS exposure, brain penetration, target engagement, and translational biomarkers
Lead clinical pharmacology strategy for CNS and neuroscience programs from first‑in‑human through registrational and post‑marketing stages
Design, execute, and interpret clinical pharmacology studies, including FIH, multiple‑ascending dose, DDI, biopharmaceutics, and patient studies
Serve as the clinical pharmacology lead on program teams, clinical sub‑teams, and trial working groups
Author and oversee clinical pharmacology sections of regulatory documents (e.g., INDs, CTAs, IBs, NDAs)
Represent clinical pharmacology in interactions with FDA and other global health authorities, supporting dose justification and labeling discussions
Partner closely with DMPK, Translational Sciences, Clinical Development, Biomarkers, Biostatistics, CMC, and Regulatory Affairs
Oversee CROs and external vendors conducting clinical pharmacology and modeling activities
Ensure timely communication and clear interpretation of clinical pharmacology results to internal stakeholders
Contribute to portfolio strategy, program prioritization, risk mitigation, and long‑range clinical development planning for CNS assets
Serve as a subject‑matter expert on clinical pharmacology
Mentor and develop clinical pharmacology talent as the pipeline and organization grow
Ensure high‑quality, submission‑ready documentation aligned with global regulatory standards
Qualifications
PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline
8–12+ years of experience in clinical pharmacology within biopharma, with demonstrated impact in translational science in drug development
Strong expertise in PK, PD, PK/PD integration, exposure–response analyses, and drug–drug interaction assessment
Extensive experience developing and executing clinical pharmacology strategies for early‑ through late‑stage programs, including registrational support
Demonstrated experience applying quantitative clinical pharmacology and translational approaches (e.g., population PK, mechanistic PK/PD modeling) to inform CNS dose selection and optimization
Proficiency with clinical pharmacology tools and platforms such as NONMEM, R, Phoenix WinNonlin, SimCyp, or equivalent
Experience authoring and delivering clinical pharmacology components of regulatory submissions (e.g., INDs, CTAs, NDAs) and interacting with global health authorities
Strong understanding of translational PK, CNS exposure considerations, and biomarker integration in neuroscience drug development
Excellent communication, collaboration, and leadership skills with the ability to operate effectively in a fast‑paced, matrixed environment
Compensation
The annual base salary range for this position is $195,000 to $275,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge and location.
In addition to base pay, this role is eligible for a discretionary annual bonus. The Company also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.
Work Location
The Senior Director, Clinical Pharmacology role is remote based, with occasional travel.
POSITION: Full-Time, Exempt
EEOC Statement: Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.
A wholly owned subsidiary of Eli Lilly and Company.
Industry
Biotechnology Research
Company size
51-200 employees
Founded
2021
LinkedIn followers
14,105
Total funding
$1.1B
Centessa Pharmaceuticals plc, a wholly owned subsidiary of Eli Lilly and Company, is developing a portfolio of orexin receptor 2 (OX2R) agonists for the potential treatment of sleep-wake and other neuroscience disorders.