San Diego, California, United States · Hybrid
$110k–$120k/yr
Scientist II, Protein Expression and Purification Location: San Diego, CA Job Type: Full-Time Compensation: $110,000 to $120,000 About Us We are a venture-backed, stealth-stage biotechnology company based in San Diego, f…
Skills: Protein Expression, Protein Purification, Biochemical Assays, Spectroscopic Assays, Fluorescence-based Assays
San Diego, California, United States · On-site
$118k–$176k/yr
RELOCATION ASSISTANCE: No relocation assistance available CLEARANCE REQUIRED FOR START: No CLEARANCE TYPE: Secret TRAVEL: NoDescription At Northrop Grumman, our employees have incredible opportunities to work on revoluti…
Skills: Cost Control Analysis, Earned Value Management, Financial Forecasting, Budget Preparation, Variance Analysis
San Diego, California, United States · On-site
$180k–$270k/yr
Company:Qualcomm Technologies, Inc. Job Area:Engineering Group, Engineering Group > Security Engineering General Summary: Job function includes participation in product security incident response, security research on Qu…
Skills: Product Security, Regulatory Compliance, Secure Development Lifecycle, Threat Modeling, Security Risk Assessment
San Diego, California, United States · On-site
$17/hr–$19/hr
Description **This is a temporary, full-time position with a openings on 1st, 2nd, and 3rd shift. Permanent placement opportunities may be available based on business need.** SUMMARY The role of a Manufacturing Associate…
Skills: Machinery Monitoring, Visual Inspection, Inventory Documentation, Subcomponent Assembly, Packaging
San Diego, California, United States · Hybrid
$85k–$90k/yr
Description Location: NAS North Island, CA Security Clearance Requirement: Secret Telework Eligible? This is a hybrid role; the selected candidate must live within a two-hour distance from the work location. Regular on-s…
Skills: Avionics Maintenance, Instructional Design, Adult Learning Methodologies, Curriculum Auditing, Technical Validation
San Diego, California, United States · On-site
$95k–$115k/yr
Description We are seeking an experienced Veeva eQMS Specialist with deep expertise in Veeva Basics, ideally someone who has led or played a key role in full implementations across QualityDocs, QMS, Training, and other V…
Skills: Veeva Vault, eQMS Implementation, QualityDocs, GxP, 21 CFR Part 11
Aliso Viejo, California, United States · Hybrid
$143k–$304k/yr
Overview Microsoft Silicon, Cloud Hardware, and Infrastructure Engineering (SCHIE) is the team behind Microsoft’s expanding Cloud Infrastructure and responsible for powering Microsoft’s “Intelligent Cloud” mission. SCHIE…
Skills: System Technical Leadership, AI Systems Design, GPU Platforms, Power Delivery, Thermal Management
San Diego, California, United States · Hybrid
$136k–$195k/yr
Sanford Burnham Prebys is much more than a research facility and hub for innovation; it’s a vibrant global community of talented scientists and researchers from over 30 countries. This worldwide representation enri…
Skills: HPC Strategy, Infrastructure Management, Team Leadership, Cloud Computing, Hybrid Computing
San Diego, California, United States · On-site
Overview VTG is seeking Systems Engineers/Technical Specialists (Mid) in San Diego, CA, and Hampton Roads, VA. The Systems Engineers/Technical Specialist will support AN/SQQ-89(V) technical data, training, and software m…
Skills: Systems Engineering, Technical Documentation, Courseware Development, Software Management, Configuration Management
San Diego, California, United States · On-site
Overview VTG is seeking Senior Systems Engineers to serve as subject matter experts on the AN/SQQ-89(V) Undersea Warfare combat system in San Diego, CA, and Hampton Roads, VA. These positions lead technical data authorin…
Skills: Systems Engineering, S1000D Technical Data Authoring, Software/Firmware Management, Security Engineering, Systems Integration
San Diego, California, United States · On-site
$125k–$237k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: CAR T-cell Therapy, mRNA-tLNP, In Vitro Preclinical Development, Immunotherapy, Assay Development
San Diego, California, United States · Remote OK
$33/hr–$35/hr
Exodigo is the leading underground mapping solution for non-intrusive discovery. Our platforms combine multi-sensor fusion, 3D imaging, and AI technologies to create complete, accurate underground maps that enable confid…
Skills: Utility Locating, SUE, Electromagnetic Locating, GPR, Seismic Sensors
San Diego, California, United States · On-site
$70k–$85k/yr
Company Description Brainlab revolutionized digital medical technology with the introduction of software for radiosurgery and surgical navigation. Today, Brainlab is an industry leader in digital surgery, radiotherapy an…
Skills: Clinical Consulting, Problem Solving, Technical Support, Medical Terminology, Surgical Procedures
San Diego, California, United States · On-site
SAIC is seeking a Senior Logistics Analyst to serve as a subject matter expert supporting the sustainment and modernization of Navy VLF shore-based communications systems. Working within an Integrated Product Team (IPT) …
Skills: RCM Methodology, FMEA, FMECA, Maintenance Requirement Cards, Maintenance Index Pages
San Diego, California, United States · On-site
$120k–$213k/yr
This Opportunity We are seeking an experienced Manager, Systems Engineering - Renewable Energy in San Diego, CA to lead technical risk assessments and mitigation strategies across utility-scale renewable energy, battery …
Skills: Technical Due Diligence, Renewable Energy Engineering, Risk Mitigation, BESS, Solar PV
San Diego, California, United States · Remote OK
$200k–$225k/yr
Company Description Work with Us. Change the World. At AECOM, we're delivering a better world. Whether improving your commute, keeping the lights on, providing access to clean water, or transforming skylines, our work he…
Skills: Client Account Management, Strategic Planning, Market Analysis, Capture Management, SalesForce Management
San Diego, California, United States · On-site
$120k–$140k/yr
Job Description As a Senior Rev Ops Administrator at Altium, you’ll play a vital role at Altium. We are looking for an individual that will be central to continually improving and enhancing the Salesforce platform for ou…
Skills: Salesforce Administration, Salesforce CPQ, Apex, Visualforce, Lightning Web Components
San Diego, California, United States · On-site
$20/hr–$22/hr
Maintenance Supervisor Department: Engineering / MaintenanceReports To: General ManagerPosition Type: Full-Time, ExemptSchedule: Varies; must be available for evenings, weekends, holidays, and on-call emergencies Positio…
Skills: HVAC, Plumbing, Electrical, Carpentry, Preventive Maintenance
Cupertino, California, United States · On-site
At Apple, great ideas have a way of becoming great products, services, and customer experiences very quickly. Bring passion and dedication to your job and there's no telling what you could accomplish. Are you interested …
Skills: Swift, UIKit, SwiftUI, Objective-C, UI Architecture
San Diego, California, United States · On-site
SAIC is seeking a Senior Test Engineer to lead and support the planning, execution, direction, analysis, and reporting of experimental, developmental, and operational testing for advanced Navy capabilities. This role bui…
Skills: Operational Testing, Test Direction, Cross-functional Leadership, Test Documentation, Technical Communication
San Diego, California, United States • Hybrid
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The role involves cloning, expressing, and purifying protein constructs while optimizing bacterial expression conditions. The scientist will also develop, validate, and troubleshoot biochemical, spectroscopic, and fluorescence-based assays to support a multi-omics platform.
Requires a B.S. with 4–6 years of experience or an M.S. with 2–4 years of experience in Biochemistry, Molecular Biology, or a related field. Candidates must have hands-on experience with biochemical assays, gel electrophoresis, and data visualization software.
Scientist II, Protein Expression and Purification
Location: San Diego, CA
Job Type: Full-Time
Compensation: $110,000 to $120,000
About Us
We are a venture-backed, stealth-stage biotechnology company based in San Diego, focused on developing novel technologies that will redefine how disease is detected, characterized, and managed with a novel approach to clinical genomics. Our mission is to fundamentally transform healthcare through a convergence of innovation across multiple scientific disciplines.
Founded by industry veterans with decades of experience in life sciences tools and diagnostics, our leadership team brings a proven track record of translating scientific insight into successful commercial products. Our investors include some of the most respected names in healthcare and deep tech.
Position Overview
We are seeking a Scientist II, Enzyme Assay & Characterization to play a key role in developing and executing biochemical assays that support the company’s multi-omics platform development. This individual will optimize and implement assays.
The Scientist II will contribute directly to enzyme evaluation. This role offers opportunities for broad technical growth, including assay development, molecular biology, protein engineering and integration.
The candidate must be detail-oriented, analytical, and collaborative, thriving in a dynamic environment that values innovation, cross-disciplinary interaction, and scientific rigor.
· Clone, express, and screen protein constructs in bacterial expression systems.
· Optimize bacterial expression conditions.
· Execute purification workflows.
· Characterize protein quality.
· Optimize and implement biochemical assays.
· Develop, optimize, and validate spectroscopic and fluorescence-based assays.
· Troubleshoot and refine assays for reproducibility, sensitivity, and throughput.
· Collaborate closely with protein expression/purification, enzymology, protein engineering, and molecular biology teams.
· Document methods, maintain rigorous records, contribute to SOPs and prepare data summaries and reports.
· Support lab organization, maintain equipment, and ensure compliance with safety and reproducibility practices.
Qualifications
Required
· B.S. in Biochemistry, Molecular Biology, Enzymology, or related field with 4–6 years
of relevant experience, OR M.S. with 2–4 years of relevant experience.
· Demonstrated experience optimizing and implementing biochemical assays.
· Hands-on experience with spectroscopic and fluorescence-based assays.
· Hands-on experience with gel electrophoresis and gel-based assays.
· Strong experience with data visualization software.
· Excellent organizational, problem-solving, and communication skills.
· Ability to work independently and collaboratively in cross-functional teams.
· Influence the foundational technologies and strategies of a company poised to shape the future of clinical genomics and healthcare.
· Work in a dynamic, collaborative environment where innovation and scientific rigor are deeply valued.
· Join a seasoned and multidisciplinary team tackling high-impact problems at the intersection of science and engineering.
· Competitive compensation and equity package, comprehensive benefits, and flexibility to support work-life integration.
We are an equal opportunity employer. We thrive on diversity and collaboration.
A center for entrepreneurial innovation at the intersection of AI and data science
Foresite Labs creates companies at the intersection of AI/machine learning and science. We believe AI, generative AI, and data science—when applied with scientific rigor—can accelerate discovery and drive innovations that benefit humanity. We provide the foundation for bold ideas to take shape and accelerate, shaping a better future for all. We offer competitive salaries, excellent benefits, and a flexible work environment where employees learn from top thinkers across multiple disciplines. With headquarters in San Francisco and Boston, we’re building a culture where scientific rigor meets entrepreneurial ambition. Foresite Labs Values Truth over progression: We follow the science, pursuing ideas that are grounded in data and abandoning them when not supported by the evidence. Take good risks: Our culture values informed risk-taking: good decisions are celebrated even when they result in bad outcomes. Everyone feels safe to contribute ideas and to learn from failure. Single accountable person: The project team lead is accountable for all decisions and for maintaining transparency and information flow within the team; we trust the project teams. The Review Committee unlocks capital and sets directions. Simplicity and Focus: “Companies die from indigestion, not starvation” (Bill Hewlett) We will focus on a few ideas aggressively and minimize all other distractions. Everyone will have a few key goals that have measurable outcomes. Respect and Community: Our employees are our greatest asset; everyone invests in creating an environment of collaboration and respect. We support their careers and career development whether they stay, go to a Labs company, or end up somewhere else.
Offices: 601 California St, Suite 600, San Francisco, California 94108, US · 625 Massachusetts Ave, 2nd Floor, Cambridge, MA 02139, US
Based on 2578 listings with disclosed salaries, most engineering jobs in San Diego, CA pay between $79k–$210k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 2,986 open engineering positions in San Diego, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Qualcomm, Northrop Grumman, Northrop Grumman Mission Systems, Inc., Apple, Solar Turbines, among others. Browse the listings above to see every active employer.
Yes — 565 of the 2986 open engineering positions offer remote or hybrid work (100 remote, 465 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
