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The Research Officer will perform in vivo studies and cell culture work to develop CAR T-cell therapies for gastrointestinal cancers. Responsibilities include conducting flow cytometry, cytotoxicity assays, and managing laboratory biosafety and equipment.
A Bachelor's degree in Science, Biomedicine, or a related field is required. Candidates should possess a strong passion for tumor immunology and be detail-oriented with excellent communication skills.
About the Position:
We are seeking a highly motivated Research Officer to join our translational research team working on cutting-edge CAR T-cell therapies for gastrointestinal cancers. This role offers an excellent opportunity to contribute to innovative cancer immunotherapy research in a dynamic and supportive academic-clinical environment.
Key Responsibilities:
- Perform in vivo studies including tumor implantation and whole-body bioluminescence imaging of tumor-bearing NSG mice using the IVIS Spectrum system.
- Expand and maintain human immune cells and organoids.
- Conduct retroviral transduction for CAR T-cell generation.
- Perform multi-parameter flow cytometry analysis.
- Execute tumor cytotoxicity assays using the Tecan Infinite 200 Pro plate reader.
- Conduct live-cell imaging of 3D tumor spheroids using the S3 IncuCyte system.
- Support laboratory biosafety management, equipment maintenance, and ordering of experimental reagents and materials.
Requirements:
- Bachelor’s Degree in Science, Biomedicine (BSc), or a related field.
- Strong passion for tumor immunology, immune evasion mechanisms, immune activation and tolerance, protein structure and function, and immune cell engineering.
- Diligent, self-motivated, conscientious, and team-oriented.
- Detail-oriented with a strong sense of responsibility and ownership.
- Excellent communication skills, along with strong analytical and critical thinking abilities.
What We Offer:
- Opportunity to work on impactful, translational cancer immunotherapy.
- Access to advanced technologies -- In vivo imaging system, IncuCyte live cell spheroid imaging, flow cytometry analysis, Olink proteomics, Pixelgen functional interactomics.
- This is a full-time contract position. Candidates with prior hands-on experience in mouse models and whole body IVIS imaging system are strongly encouraged to apply.
Contact: Dr SEOW See-Voon
Email: [email protected]
SingHealth drives the transformation of healthcare and provides affordable, accessible, quality healthcare. With over 40 clinical specialties, a network of acute hospitals, national specialty centres, polyclinics and community hospitals, it delivers comprehensive, multidisciplinary and integrated care. As part of the SingHealth Duke-NUS Academic Medical Centre, SingHealth works with Duke-NUS Medical School to advance medical research and education to improve patient care.
Offices: 10 Hospital Boulevard, Bukit Merah, 168582, SG
