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Skills: Process R&D, Enzymatic ligation, Oligonucleotide production, Analytical testing, Process chemistry
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The Research Associate will conduct process R&D activities for developing and optimizing enzymatic ligation and downstream processes for oligonucleotide production. They will also ensure compliance with SOPs and cGMP while supporting cross-functional project teams.
Candidates must hold a bachelor's degree in chemistry, biochemistry, or chemical engineering with at least two years of industrial pharmaceutical experience. Proficiency in process chemistry and laboratory documentation is required, with a master's degree preferred.
Agilent inspires and supports discoveries that advance the quality of life. We provide life science, diagnostic and applied market laboratories worldwide with instruments, services, consumables, applications and expertise. Agilent enables customers to gain the answers and insights they seek ---- so they can do what they do best: improve the world around us. Information about Agilent is available at www.agilent.com.
We are seeking a Research Associate to join the team. The candidate will be responsible for conducting process R&D activities for developing and optimizing enzymatic ligation and downstream processes at the lab scale for tech transfer to large-scale oligonucleotide production. This includes assisting in developing and optimizing ligation process, methods, and techniques in preparing, separating, purifying, analyzing, quantifying, and resolving oligonucleotide process components and objectives.
· Studying and implementing R&D project objectives and targets related to chemical and engineering requirements of oligonucleotide production processes
· Apply knowledge and laboratory experience in chemistry and analytical testing by implementing strategies and optimizing chemical reactions, methods and processes
· Execute process development experiments and activities related to enzymatic ligation and downstream processing of complex oligonucleotides
· Complete experimental notebooks and records adhering to standard operating procedures (SOP's) and current good manufacturing practices to maintain compliance integrity (cGMP)
· Participate in cross-functional teams and support project teams in all stages of oligonucleotide research and development
· Bachelor’s in chemistry, biochemistry, chemical engineering, biochemical engineering or related science discipline
· Two years of industrial experience post-graduation in a pharmaceutical environment
· Knowledge and understanding of process chemistry and development
· Ability to work both independently and in a team setting on a variety of projects
· Master’s Degree preferred
· Knowledge of enzymatic manipulation of DNA/RNA and biocatalysis
· Detail and results oriented with experience in experimental plan and execution, data analysis, and documentation
· General proficiency with tools, systems, and procedures
Let’s Bring Great Science to Life.
Agilent customers are finding new ways to treat cancer, ensure food, water, air, and medicine quality and safety, discover new drug treatments, research infectious diseases, and create alternative energy solutions for a greener planet. From start to finish, we have them covered with our vast product solutions and services portfolio. Around the world, Agilent’s people bring innovations, technologies, and services to the forefront of science. Our teams design and manufacture a wide array of advanced analytical, research, and diagnostic solutions and tools for use inside and outside laboratories. Additionally, the unique expertise of Agilent’s CrossLab and technical teams provides valuable insight and support to our customers, helping them fully optimize their laboratories and resources to better focus on what's important: bringing great science to life. In fiscal 2022, Agilent Technologies generated revenue of (US) $6.85 billion.
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