South San Francisco, California, United States · On-site
$200k–$245k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, C++, C, Trajectory Generation, Model Predictive Control
South San Francisco, California, United States · On-site
$180k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full-stack Engineering, System Design, Scalable Systems, Python, Go
South San Francisco, California, United States · On-site
$180k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full Stack Development, Frontend Development, Backend Development, System Design, API Design
South San Francisco, California, United States · On-site
$180k–$265k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Deep Learning, 3D Geometry, Semantic Segmentation, Computer Vision, CNN
South San Francisco, California, United States · On-site
$180k–$240k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Cloud Infrastructure, Kubernetes, Infrastructure As Code, Observability, Networking
South San Francisco, California, United States · On-site
$190k–$230k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: C++, Rust, C, Python, Simulation Systems
South San Francisco, California, United States · On-site
$180k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full Stack Development, Backend Services, Data Pipelines, Marketplace Dynamics, System Architecture
South San Francisco, California, United States · On-site
$162k–$300k/yr
Principal Business Product Manager - 360 Insights Why Genentech We're passionate about improving patient lives and building healthier communities—leading with inclusivity, integrity, and creativity to tackle the world's …
Skills: Product Strategy, Pharmaceutical Analytics, Agile Methodology, Stakeholder Management, Data Science
South San Francisco, California, United States · On-site
About Human Longevity, Inc. (HLI) Human Longevity, Inc. (HLI) is a leader in precision health, combining genomics, advanced imaging, biomarker testing, and artificial intelligence to transform the future of proactive hea…
Skills: Python, SQL, Large Language Models, Retrieval-Augmented Generation, AI Agents
South San Francisco, California, United States · Hybrid
$170k–$200k/yr
Color Health is revolutionizing cancer care with the nation’s first Virtual Cancer Clinic, delivering high-quality, physician-led multidisciplinary care across all 50 states. Our innovative, guideline-based approach span…
Skills: Product Management, Business Operations Platforms, AI Integration, Roadmap Strategy, Cross-functional Leadership
South San Francisco, California, United States · Hybrid
$183k–$225k/yr
At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees…
Skills: Windows Server, IIS, SQL Server, Docker, AWS
South San Francisco, California, United States · On-site
$161k–$312k/yr
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more t…
Skills: Self-supervised Representation Learning, Generative Modeling, Deep Learning, Machine Learning, Computational Science
San Francisco, California, United States · Hybrid
$138k–$246k/yr
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headqua…
Skills: System Architecture, People Management, Agile Methodology, Cloud Computing, CI/CD
South San Francisco, California, United States · Hybrid
$158k–$263k/yr
Purpose of Onyx The Onyx Research Data Tech organization is GSK’s Research data ecosystem which has the capability to bring together, analyze, and power the exploration of data at scale. We partner with scientists across…
Skills: Python, GCP, Azure, AWS, Spark
South San Francisco, California, United States · On-site
$129k–$239k/yr
Why Genentech We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while boldly p…
Skills: UX/UI Design, User-Centered Design, Figma, Rapid Prototyping, Wireframing
South San Francisco, California, United States · On-site
$145k–$185k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: C, C++, Python, Linux Kernel, Real-time Systems
South San Francisco, California, United States · On-site
$148k–$320k/yr
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more t…
Skills: Machine Learning, Python, PyTorch, JAX, Tensorflow
South San Francisco, California, United States · Remote OK
$220k–$275k/yr
Job Title: Principal Software Engineer Location: South San Francisco, CA preferred; Remote optional Job Type: Full-time About the Role We're seeking a Principal Software Engineer to join Natera's R&D Platform Infrastruct…
Skills: Cloud Infrastructure, Kubernetes, Terraform, Python, Go
South San Francisco, California, United States · On-site
$140k–$190k/yr
Aechelon Technology, Inc. is a leading producer of 3D simulator content, including Geospecific visual/sensor databases and realistic 3D models. We seek people who share our passion for real-time computer graphics and com…
Skills: Product Management, Stakeholder Management, Product Roadmap Strategy, Requirement Analysis, Backlog Prioritization
South San Francisco, California, United States · On-site
$120k–$156k/yr
Aechelon Technology, Inc. is a leading producer of 3D simulator content, including Geospecific visual/sensor databases and realistic 3D models. We seek people who share our passion for real-time computer graphics and com…
Skills: Software Testing, Automation Development, Python, C++, AI Tools
South San Francisco, California, United States • On-site
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Develop real-time trajectory generation and decision-making systems for autonomous flight, balancing safety, energy, and reliability. Validate software through large-scale simulation and fleet data to ensure robustness in uncertain environments.
Requires a Master's degree in Computer Science or a related field with 3+ years of experience in safety-critical software for aerospace or robotics. Proficiency in Rust, C++, or C for embedded Linux environments is essential.
Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We design, build, and operate the world’s largest autonomous logistics system, delivering critical supplies quickly and reliably. Today, Zipline operates on four continents, makes a delivery somewhere in the world every 30 seconds, and has completed millions of deliveries to date, including blood, vaccines, medical supplies, food, and retail products.
Our customers include the world’s largest and most prominent healthcare systems, governments, retailers, restaurants and global businesses who rely on us to save lives, reduce emissions, increase economic opportunity, and provide delivery from point A to point B as fast as possible. The drone is only 15% of what we’ve built to enable seamless, reliable, global operations.
Our system strengthens supply chains, reduces congestion, and gives people time back. With more than 140 million commercial autonomous miles safely flown, Zipline is redefining access to healthcare, consumer products, and food across the globe.
We operate at a global scale and are looking for practical problem solvers who thrive on real-world challenges and rapid growth. Our team is motivated by building systems that have a direct, meaningful impact on people’s lives and by scaling the future of logistics. We are seeking people who sculpt from first principles, enjoy facing adversity, and can do the impossible at record breaking speeds.
Zipline was founded to create the first logistics system that serves all humans equally. Our aim is to solve the world’s most urgent and complex access challenges. Leveraging expertise in robotics and autonomy, Zipline designs, manufactures and operates the world’s largest automated delivery system. Zipline serves tens of millions of people around the world and is making good on the promise of building an equitable and more resilient global supply chain. From powering Rwanda’s national blood delivery network and Ghana’s COVID-19 vaccine distribution, to providing on-demand home delivery for Walmart and enabling leading healthcare providers to bring care into the home in the United States, Zipline is transforming the way goods move. By transitioning to clean, electric, instant logistics, we can decarbonize delivery, decrease road congestion, and reduce fossil fuel consumption and air pollution, while providing equitable access for billions of people. The technology is complex but the idea is simple: a teleportation service that delivers what you need, when you need it. Zipline is inspiring people, governments, and businesses to imagine what is possible when goods can move as seamlessly as information. To join the team, check out our career page: https://flyzipline.com/careers/
Offices: 333 Corey Way, South San Francisco, California 94080, US
Based on 72 listings with disclosed salaries, most software jobs in South San Francisco, CA pay between $152k–$270k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 85 open software positions in South San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Zipline, Roche, Xaira Therapeutics, Eli Lilly and Company, Aechelon Technology Inc., among others. Browse the listings above to see every active employer.
Yes — 12 of the 85 open software positions offer remote or hybrid work (2 remote, 10 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
