South San Francisco, California, United States · On-site
About Human Longevity, Inc. (HLI) Human Longevity, Inc. (HLI) is a leader in precision health, combining genomics, advanced imaging, biomarker testing, and artificial intelligence to transform the future of proactive hea…
Skills: Python, SQL, Large Language Models, Retrieval-Augmented Generation, AI Agents
South San Francisco, California, United States • On-site
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Design, build, and deploy production-ready AI applications and autonomous agentic systems to improve clinical and operational healthcare workflows. Develop RAG systems and scalable AI infrastructure to unlock value from genomic, imaging, and clinical data.
Requires 4+ years of experience building AI or data-driven applications specifically within healthcare or life sciences environments. Must be proficient in Python and SQL with proven experience deploying LLM-based applications to real-world users.
Human Longevity, Inc. (HLI) is a leader in precision health, combining genomics, advanced imaging, biomarker testing, and artificial intelligence to transform the future of proactive healthcare. Our mission is simple: help people live longer, healthier lives through earlier detection, personalized insights, and data-driven healthcare.
We believe AI will fundamentally reshape healthcare over the next decade. From clinician copilots and patient-facing assistants to autonomous workflows and intelligent healthcare operations, AI will become deeply embedded across every aspect of healthcare delivery.
We are looking for an exceptional Applied AI Engineer who can help build that future. This is not a traditional data science role. This is a hands-on engineering role focused on building, deploying, and scaling real-world AI applications that create measurable impact across clinical, operational, and member experiences.
As an Applied AI Engineer, you will build AI-powered products and agentic systems that help clinicians, care teams, operations staff, and members work more effectively.
You will rapidly prototype, deploy, and iterate on AI solutions using the latest advances in Large Language Models, Retrieval-Augmented Generation (RAG), agent frameworks, and healthcare data platforms.
Build AI Products
Design, build, and deploy AI-powered applications from concept to production.
Rapidly prototype new ideas and transform them into production-ready systems.
Partner directly with clinicians, operators, and business stakeholders to identify high-value opportunities.
Deliver solutions that create measurable operational, clinical, or member-facing impact.
Build AI Agents
Design and deploy autonomous and semi-autonomous AI agents.
Implement multi-agent workflows that automate complex healthcare processes.
Evaluate and integrate modern agent frameworks and orchestration platforms.
Build AI assistants that support clinical operations, member engagement, and internal productivity.
Develop LLM Applications
Build applications leveraging state-of-the-art Large Language Models.
Develop Retrieval-Augmented Generation (RAG) systems across structured and unstructured healthcare data.
Optimize prompts, workflows, evaluation systems, and agent behavior.
Implement knowledge retrieval systems that unlock value from clinical, genomic, imaging, and operational data.
Engineer AI Infrastructure
Build scalable data pipelines and AI services.
Create reusable AI components, APIs, and internal platforms.
Improve reliability, observability, performance, and security of AI systems.
Support deployment and monitoring of production AI applications.
Own End-to-End Delivery
Take ownership from idea through production deployment.
Work cross-functionally with engineering, clinical, operations, and leadership teams.
Continuously evaluate and improve AI solutions based on real-world outcomes.
Healthcare Experience (Required)
4+ years of experience building software, AI, machine learning, or data-driven applications within healthcare, life sciences, biotechnology, genomics, diagnostics, digital health, or clinical environments.
Direct experience working with healthcare data, including one or more of:
Clinical records
Laboratory data
Genomics data
Imaging reports
Physician documentation
Patient communications
Healthcare operational workflows
Strong understanding of healthcare terminology, clinical workflows, and the practical challenges of deploying AI solutions in healthcare settings.
AI Engineering Experience
Proven experience building and deploying production AI applications.
Hands-on experience with Large Language Models (LLMs) and modern AI application development.
Experience with Retrieval-Augmented Generation (RAG), agentic AI systems, prompt engineering, and workflow automation.
Strong product mindset with the ability to identify business problems and rapidly build solutions.
Experience deploying systems used by real customers, clinicians, patients, or operational teams.
Technical Skills
Strong proficiency in Python.
Experience with SQL and modern database technologies.
Experience with APIs, integrations, and distributed systems.
Familiarity with cloud platforms and modern software engineering practices.
Strong understanding of software architecture, testing, and deployment.
Experience with genomics, precision medicine, longevity medicine, radiology, pathology, or advanced diagnostics.
Experience with healthcare interoperability standards such as FHIR and HL7.
Experience building clinician-facing AI products.
Experience building patient-facing AI assistants.
Experience with healthcare privacy, security, and compliance requirements.
Startup or high-growth technology company experience.
Experience With One or More of the Following
OpenAI, Anthropic, Gemini, or similar foundation models
LangGraph
LangChain
CrewAI
AutoGen
PydanticAI
Vector databases
Enterprise search systems
Agent orchestration platforms
Workflow automation tools
You will thrive at HLI if you:
Love building and shipping products quickly.
Enjoy solving messy, real-world problems.
Are excited about the future of AI agents.
Can move from concept to production with minimal oversight.
Prefer impact over academic research.
Are energized by startup environments and rapid iteration.
Want to help transform healthcare through technology.
Work at the intersection of AI, genomics, diagnostics, and precision medicine.
Build systems used by clinicians, healthcare teams, and members every day.
Cutting-Edge Technology
Work with the latest AI models, agent frameworks, healthcare datasets, and precision medicine technologies.
Help advance HLI’s mission to extend healthy human lifespan through proactive, personalized healthcare.
Live a healthier, longer life.
Human Longevity, Inc. ™ (HLI) is the genomics-based, health intelligence company creating the world’s largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries from these data to generate personalized health insights. Our goal is to extend healthy human life by revolutionizing human health and transforming the practice of medicine. Our DNA determines so much about each of us, but other factors can also influence our health. HLI is focused on compiling and analyzing more genotypic and phenotypic data because the combination of both enables us —to generate unprecedented insights and accelerate our understanding into what makes us who we are and what we can change for a life better lived.
Offices: 600 Gateway Blvd, South San Francisco, California 94080, US · 4570 Executive Drive, San Diego, CA 92121, US
Live a healthier, longer life.
Human Longevity, Inc. ™ (HLI) is the genomics-based, health intelligence company creating the world’s largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries from these data to generate personalized health insights. Our goal is to extend healthy human life by revolutionizing human health and transforming the practice of medicine. Our DNA determines so much about each of us, but other factors can also influence our health. HLI is focused on compiling and analyzing more genotypic and phenotypic data because the combination of both enables us —to generate unprecedented insights and accelerate our understanding into what makes us who we are and what we can change for a life better lived.
Offices: 600 Gateway Blvd, South San Francisco, California 94080, US · 4570 Executive Drive, San Diego, CA 92121, US
