South San Francisco, California, United States · On-site
$180k–$225k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Product Management, System Design, Marketplace Economics, Technical Fluency, Behavioral Economics
South San Francisco, California, United States · On-site
$113k–$300k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Generative AI, Large Language Models, Python, TypeScript, JavaScript
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Path Planning Algorithms, Algorithmic Optimization, Coding, Programming, Automated Testing
South San Francisco, California, United States · On-site
$10k–$13k/mo
About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and a…
Skills: Computer Vision, Multimodal AI, Python, PyTorch, TensorFlow
South San Francisco, California, United States · On-site
$120k–$240k/yr
About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and a…
Skills: Deep Learning, PyTorch, GPU Training, Distributed Training, Computational Protein Design
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: React Native, Python, Go, Computer Science Fundamentals, Software Development
South San Francisco, California, United States · On-site
$152k–$190k/yr
About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and a…
Skills: Lab Automation, Liquid Handling, Python, C#, SQL
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, Python, Pytest, Unittest, Linux
South San Francisco, California, United States · On-site
$129k–$145k/yr
Work Schedule Standard (Mon-Fri) Environmental Conditions Office Job Description As part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. Join our coll…
Skills: Bioinformatics Pipelines, Next-Generation Sequencing, Python, Perl, Shell Scripting
South San Francisco, California, United States · Hybrid
$229k–$302k/yr
The Position Genentech, Inc. seeks a Principal Software Engineer at its South San Francisco, CA location. Duties: Identify innovative and sustainable solutions to improve data management and business processes to address…
Skills: Object-Oriented Design, Microservices Architecture, Amazon Web Services (AWS), Java, Python
South San Francisco, California, United States · On-site
$136k–$170k/yr
About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and a…
Skills: Single-cell RNA sequencing, Perturb-seq, Bioinformatics Pipelines, Python, Nextflow
South San Francisco, California, United States · On-site
$165k–$245k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, C++, Embedded Linux, Interprocess Communication, Concurrency
South San Francisco, California, United States · Hybrid
$190k–$286k/yr
Who we are About Stripe Stripe, LLC. is a financial infrastructure platform for businesses. Millions of companies - from the world’s largest enterprises to the most ambitious startups - use Stripe to accept payments, gro…
Skills: Java, C++, Scala, Javascript, Ruby
South San Francisco, California, United States · Hybrid
About Deep Origin Led by Michael Antonov, a co-founder of Oculus, and well-funded by Formic Ventures, Deep Origin is poised to reinvent the way scientists work and life science innovations come to life. We see a future l…
Skills: NodeJS, React, TypeScript, JavaScript, Postgres
South San Francisco, California, United States · On-site
$225k–$280k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Rust, C++, C, Trajectory Optimization, MPC
South San Francisco, California, United States · On-site
$150k–$180k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Python, Pytest, Rust, C, CI/CD
South San Francisco, California, United States · On-site
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: CAD, Embedded Software, Mechanical Engineering, Prototyping, Sensor Integration
South San Francisco, California, United States · On-site
$160k–$220k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Python, Embedded C, Rust, Object Oriented Programming, Git
South San Francisco, California, United States · On-site
$210k–$250k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Real-time Systems, API Design, Distributed Systems, AWS, Kubernetes
South San Francisco, California, United States · On-site
$200k–$270k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full Stack Development, Frontend Development, Backend Development, System Design, API Design
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Lead the economic shaping of Zipline's marketplace by partnering with engineering, operations, and leadership to optimize delivery execution. Identify operational inefficiencies through field research and data to drive product roadmaps and scalable solutions.
Requires a strong technical background, ideally transitioning from software engineering into product leadership, with experience in logistics or marketplace software. Must possess deep operational judgment and the ability to translate ambiguous problems into actionable technical priorities.
Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We design, build, and operate the world’s largest autonomous logistics system, delivering critical supplies quickly and reliably. Today, Zipline operates on four continents, makes a delivery somewhere in the world every 30 seconds, and has completed millions of deliveries to date, including blood, vaccines, medical supplies, food, and retail products.
Our customers include the world’s largest and most prominent healthcare systems, governments, retailers, restaurants and global businesses who rely on us to save lives, reduce emissions, increase economic opportunity, and provide delivery from point A to point B as fast as possible. The drone is only 15% of what we’ve built to enable seamless, reliable, global operations.
Our system strengthens supply chains, reduces congestion, and gives people time back. With more than 140 million commercial autonomous miles safely flown, Zipline is redefining access to healthcare, consumer products, and food across the globe.
We operate at a global scale and are looking for practical problem solvers who thrive on real-world challenges and rapid growth. Our team is motivated by building systems that have a direct, meaningful impact on people’s lives and by scaling the future of logistics. We are seeking people who sculpt from first principles, enjoy facing adversity, and can do the impossible at record breaking speeds.
● Experience building software for delivery operations, retail operations, fulfillment, or restaurant workflows
● Experience with experimentation and analytical feedback loops
● Background in high-growth or operationally complex environments
Zipline was founded to create the first logistics system that serves all humans equally. Our aim is to solve the world’s most urgent and complex access challenges. Leveraging expertise in robotics and autonomy, Zipline designs, manufactures and operates the world’s largest automated delivery system. Zipline serves tens of millions of people around the world and is making good on the promise of building an equitable and more resilient global supply chain. From powering Rwanda’s national blood delivery network and Ghana’s COVID-19 vaccine distribution, to providing on-demand home delivery for Walmart and enabling leading healthcare providers to bring care into the home in the United States, Zipline is transforming the way goods move. By transitioning to clean, electric, instant logistics, we can decarbonize delivery, decrease road congestion, and reduce fossil fuel consumption and air pollution, while providing equitable access for billions of people. The technology is complex but the idea is simple: a teleportation service that delivers what you need, when you need it. Zipline is inspiring people, governments, and businesses to imagine what is possible when goods can move as seamlessly as information. To join the team, check out our career page: https://flyzipline.com/careers/
Offices: 333 Corey Way, South San Francisco, California 94080, US
Based on 72 listings with disclosed salaries, most software jobs in South San Francisco, CA pay between $152k–$270k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 85 open software positions in South San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Zipline, Roche, Xaira Therapeutics, Eli Lilly and Company, Aechelon Technology Inc., among others. Browse the listings above to see every active employer.
Yes — 12 of the 85 open software positions offer remote or hybrid work (2 remote, 10 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
