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About Parabilis Medicines Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets lon…
Skills: Phage Display, mRNA Display, Molecular Biology, Protein Engineering, Chemical Biology
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Cambridge, Massachusetts, United States · Hybrid
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Beverly, Massachusetts, United States · On-site
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Boston, Massachusetts, United States · On-site
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Cambridge, Massachusetts, United States · On-site
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Cambridge, Massachusetts, United States • On-site
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Design and execute high-throughput phage and mRNA display screening campaigns to discover novel binders for challenging protein targets. Develop and optimize display libraries and workflows while collaborating with cross-functional teams to advance discovery programs.
Requires a PhD in Molecular Biology, Biochemistry, or a related field with 0-2 years of experience. Candidates must possess strong foundations in molecular biology techniques and experience with biochemical screening or display technologies.
About Parabilis Medicines
Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact. For more information, visit www.parabilismed.com or follow us on LinkedIn.
We are seeking a highly motivated Scientist to join our Hit Discovery team and contribute to the advancement our Helicon Discovery Platform through the development and application of phage display and mRNA display technologies. This role is ideal for a recent PhD graduate or early-career scientist with a strong foundation in molecular biology, protein engineering, chemical biology, or a related discipline. The successful candidate will contribute to screening campaigns against previously “undruggable” protein targets, support the development and integration of noncanonical amino acids into mRNA display platform, and help innovate and optimize display screening workflows. This is an excellent opportunity to work in a fast-paced, highly collaborative environment focused on building next-generation discovery capabilities and discovering transformative therapeutics.
Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.
The base salary range for this position is $110,000-$130,000, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.
As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.
30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com
We are dedicated to creating extraordinary medicines for people affected by serious diseases
Parabilis Medicines™ is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.
Offices: 30 Acorn Park Dr, Cambridge, MA 02140, US
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