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Skills: CMC Operations, Project management, Drug product development, Manufacturing operations, Tech transfer
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Boston, Massachusetts, United States · Remote OK
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Senior$1.5B raised
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Boston, Massachusetts, United States · On-site
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Vertex Inc.
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$110k–$120k/yr
Full-time
bachelor degree, postgraduate degree
Bonus, Equity, Health insurance
Posted 2d ago
~40 hrs/week
Responsibilities
The Associate Manager will coordinate cross-program planning and execution across CMC, Regulatory, and QA departments to ensure manufacturing milestones are met. They are responsible for managing integrated timelines, identifying risks, and driving accountability with external CDMO partners.
Requirements
Candidates must hold a bachelor's degree in a scientific or engineering field with 5-7+ years of relevant experience in biologics or cell/gene therapy. Proficiency in project management tools and a strong understanding of CMC and manufacturing terminology are required.
Full job description
Job Description:
Company Overview
Founded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY® (exagamglogene autotemcel [exa-cel]), the world’s first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependent beta thalassemia. CRISPR Therapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTase™ editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics has established strategic collaborations with leading biopharmaceutical partners, includingVertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug,Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco,California.
Position Summary
The Associate Manager, CMC Operations supports the CMC Lead across multiple concurrent drug product development programs and external manufacturing operations. This role drives cross-program planning, coordination, and execution tracking — managing integrated timelines, risk and action logs, and cross-functional deliverables — so that CMC, Regulatory, QA, and CDMO partners stay aligned and program milestones are met. This is a hands-on operations role, not a purely administrative one: the person in this role will need to understand CMC and manufacturing context well enough to flag risks proactively, not just track tasks.
Responsibilities
Build and maintain integrated cross-program timelines spanning tech transfer, process development, manufacturing campaigns, and regulatory-supporting deliverables.
Own program-level risk and action logs; proactively identify dependencies, conflicts, and timeline risks across the 3 active programs and escalate as needed.
Coordinate deliverables and follow-through across CMC, Regulatory, QA, and external CDMO partners, driving accountability without formal authority over those groups.
Track CDMO batch scheduling, tech transfer milestones, and manufacturing deliverables; flag scheduling conflicts or resourcing gaps early.
Support budget, purchase order, and supply planning inputs relevant to external DP manufacturing activities.
Prepare status reports, dashboards, and meeting materials for program and governance reviews; ensure meeting follow-through and documentation.
Partner with the CMC Lead to prioritize work across programs based on regulatory milestones and business impact.
Project/timeline management experience in a CMC, drug substance/drug product, or biologics environment, with skill in cross-program plans, risk logs, and action trackers.
Working fluency in CMC/manufacturing terminology (tech transfer, batch records, GMP milestones, CDMO interactions) to flag risk, not just log tasks.
Strong cross-functional communication skills to drive accountability across CMC, Regulatory, QA, and CDMO partners without formal authority.
Minimum Qualifications
Bachelor's degree in a scientific, engineering, or related technical field; advanced degree a plus and 5-7+ years of relevant experience, or advanced degree and 4-6 years.
Prior experience supporting biologics, cell/gene therapy, or LNP-based drug product programs.
Familiarity with project management tools (e.g., Smartsheet, MS Project, or similar) for multi-program tracking.
Preferred Qualifications
Strong analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective.
Competencies
Collaborative – Openness, One Team
Undaunted – Fearless, Can-do attitude
Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
CRISPR Therapeutics believes in fostering a dynamic workplace that balances remote work flexibility with the benefits of in-person interactions. Our employees work at least three days on-site, creating a collaborative work environment, where we cultivate mentorship opportunities, increase cross-functional communication and offer opportunities for our employees to connect. Certain lab based and manufacturing positions are located fully on-site.
Associate Manager, CMC Operations: Base pay range of $110,000 to $120,000+ bonus, equity and benefits
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
Since its inception over a decade ago, CRISPR Therapeutics has evolved from a research-stage company advancing gene editing programs into a leader that celebrated the historic approval of the first-ever CRISPR-based therapy. The Company has a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular, autoimmune, and rare diseases. In 2018, CRISPR Therapeutics advanced the first-ever CRISPR/Cas9 gene-edited therapy into the clinic to investigate the treatment of sickle cell disease and transfusion-dependent beta thalassemia. Beginning in late 2023, CASGEVY® (exagamglogene autotemcel [exa-cel]) was approved in several countries to treat eligible patients with either of these conditions. The Nobel Prize-winning CRISPR technology has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has formed strategic partnerships with leading companies including Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California.
Offices: 105 West First Street, Boston, MA 02127, US · Baarerstrasse 14-16, Zug, CH CH-6300, CH · 90 Fetter Lane, London, England EC4A 1JP, GB · 455 Mission Bay Blvd S, San Francisco, California 94158, US
Based on 511 listings with disclosed salaries, most manufacturing jobs in Boston, MA pay between $32k–$195k per year. Individual offers vary with seniority, company size, and specialization.
How many Manufacturing jobs are open in Boston, MA right now?
There are currently 686 open manufacturing positions in Boston, MA listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Manufacturing roles in Boston, MA?
Companies currently hiring include WHOOP, Vertex Pharmaceuticals, Vertex Inc., mouhamedzz, Thermo Fisher Scientific, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Manufacturing jobs in Boston, MA?
Yes — 219 of the 686 open manufacturing positions offer remote or hybrid work (67 remote, 152 hybrid).
How do I apply for Manufacturing jobs in Boston, MA?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.