San Diego, California, United States · Hybrid
$126k–$257k/yr
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Skills: Artificial Intelligence, Biostatistics, Data Science, Data Visualization, Deep Learning
San Diego, California, United States · On-site
$19/hr–$29/hr
We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate…
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San Diego, California, United States · Hybrid
$126k–$257k/yr
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Skills: Artificial Intelligence, Biostatistics, Data Science, Data Visualization, Deep Learning
San Diego, California, United States · On-site
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San Diego, California, United States · On-site
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$147k–$235k/yr
As a result of the combination of the BD Biosciences and Diagnostic Solutions business with Waters Corporation (NYSE: WAT), by applying to this role, you will be applying for a position with Waters. Waters is a global le…
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San Diego, California, United States · On-site
Overview NaphCare is hiring an experienced Licensed Clinical Social Worker to join our team of medical professionals in the San Diego County Jails in San Diego, CA. As a LCSW, you will work alongside correctional officer…
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San Diego, California, United States · On-site
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San Diego, California, United States · On-site
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Superlanet is a clinician-led, woman-owned healthcare IT staffing firm supporting hospitals and health systems nationwide. We are seeking a hands-on IT Operations Analyst to support our growing workforce across the US. T…
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San Diego, California, United States · Hybrid
$87k–$131k/yr
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San Diego, California, United States · On-site
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San Diego, California, United States · Hybrid
$215k–$358k/yr
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San Diego, California, United States · On-site
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San Diego, California, United States · On-site
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San Diego, California, United States · On-site
$171k–$257k/yr
We are seeking a Senior Manager of Software Engineering to build and lead a new product engineering team in San Diego, developing software for providers in the sleep health diagnostics domain. This is a people-first lead…
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San Diego, California, United States · On-site
$34/hr–$40/hr
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San Diego, California, United States · On-site
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San Diego, California, United States · On-site
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San Diego, California, United States · On-site
$28/hr–$38/hr
The Behavior Specialist is responsible for supporting the delivery of high-quality Cognitive Behavioral Therapy (CBT) interventions within Rogers Behavioral Health treatment programs. The Behavior Specialist is trained t…
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San Diego, California, United States · On-site
$60/hr–$65/hr
Compensation Range: Hourly: $60.00 - $65.00 Position Summary Reporting directly to the Project Manager, the role of the Part-Time Advanced Practice Nurse (APN) is to assess and evaluate patient primary and behavioral hea…
Skills: Patient Assessment, Behavioral Healthcare, Primary Care, Telehealth Technology, Clinical Supervision
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Drive medicinal chemistry efforts using structure-based and ligand-based drug design to optimize small molecule drug discovery. Collaborate with interdisciplinary teams to develop predictive models and lead candidate nomination processes.
Requires a PhD in medicinal chemistry, computational biology, or a related field, or an MS with 6+ years of pharma experience. Must have 3+ years of drug discovery project experience and proficiency with computational tools like Schrodinger or OpenEye.
Internal Job Title: Senior Expert I/II, Data Science
Position Location: San Diego, CA, hybrid
Your Responsibilities Include:
Drive the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR), structure-based and ligand-based drug design, a profound understanding of target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics/pharmacodynamics (PK/PD), and synthetic feasibility.
Thrive at the intersection of experimental and groundbreaking digital technologies, with a particular emphasis on expertise in machine learning, active learning and physics-based CADD methodologies as applied to small molecule drug discovery as well as in the induced proximity space.
Stay abreast of scientific literature and engage with internal and external scientists to incorporate biological insights into lead characterization and screening initiatives.
Collaborate with interdisciplinary project teams to facilitate effective decision-making throughout the target identification, lead optimization and drug candidate nomination process. This involves applying and developing predictive models based on high-content and time-resolved screening data, including imaging techniques.
Drive hypothesis generation to enhance clinical success rates for programs involving small molecules, peptides, RNAs, protein degradation, molecular glues, transient covalent inhibitors, and kinetic stabilization of drug-target complexes.
Take a leading role in cross-disciplinary mechanistic studies using physics-based modeling and simulation, biophysical characterization, and cellular validation. These studies will inform the strategic targeting strategies of discovery projects, aiming for optimal mechanisms of action (MoAs).
PhD in medicinal chemistry, computational chemistry, computational biology, computational chemical biology, or a related field. Candidates with a laboratory-based background in chemistry and biology, supplemented with strong computational experience, are also encouraged to apply. We will also consider MS applicants with 6+ years of relevant Pharma/biotech experience.
3+ years of experience working with project teams in a drug discovery environment.
Proven track record of innovation through analogue design, leading to significant impact on discovery projects.
Familiarity with computational drug design tools (e.g. Schrdoinger, CCG, OpenEye, etc.), high-performance computing environments, and strong publication history in peer-reviewed journals.
Proactively anticipates project needs with a clinical focus.
Demonstrates rigor and diligence in idea substantiation, analogue design, and experimentation.
Strong team orientation with multitasking and adaptability in support and leadership roles.
Effective listener with excellent written and oral communication skills.
Proficient in data visualization to effectively communicate insights.
The salary for this position is expected to range between $126,000 and $234,000 USD annually for Senior Expert I, Data Science, and $138,600 and $257,400 USD annually for Senior Expert II, Data Science. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.
Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.
US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
To learn more about the culture, rewards and benefits we offer our people click here.
The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
https://www.novartis.com/careers/careers-research/notice-all-applicants-us-job-openings
Novartis is an innovative medicines company. Every day, working to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide. Find out more at https://www.novartis.com See our community guidelines: https://go.novartis.social/3Nboxki
Offices: Novartis Campus, Basel, Baselstadt 4002, CH · One Health Plaza, East Hanover, NJ 07936, US · Calle 93B S-31, Bogota, Bogota, D.C. 110541, CO · Merrion Road, Dublin, County Dublin, IE · Na Pankraci 1724/129, Prague, Prague 140 00, CZ
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