Process Chemistry Lead (Small Molecule) Location: Dublin College Park, Ireland Competitive salary and benefits Opening date: 07/08/2026 Closing date: midnight 23/08/2026 As part of AstraZeneca's API Commercialisation Pla…
Skills: Process chemistry, Small molecule synthesis, API commercialisation, Process development, Synthetic organic chemistry
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Full-time
bachelor degree, postgraduate degree
Private healthcare, Generous holiday allowance, Training and development opportunities
Posted 5d ago
Apply by Aug 24
~40 hrs/week
Responsibilities
The Process Chemistry Lead provides scientific leadership for small molecule API manufacturing processes from development through commercialisation. They act as the primary scientific authority within cross-functional teams to ensure robust, scalable, and commercially viable process delivery.
Requirements
Candidates must hold a PhD in Organic Chemistry, Process Chemistry, or a related discipline, or a BSc/MSc with significant industrial experience. Proven experience in developing and scaling chemical processes for pharmaceutical manufacturing within a GMP environment is essential.
Full job description
Process Chemistry Lead (Small Molecule)
Location: Dublin College Park, Ireland
Competitive salary and benefits
Opening date: 07/08/2026
Closing date: midnight 23/08/2026
As part of AstraZeneca's API Commercialisation Platform (APICOM), we are building a new model for delivering small molecule medicines. APICOM provides an integrated pathway from late-stage development through launch and early commercial supply, combining process development, manufacturing, analytical science, modelling and digital capabilities within a single end-to-end organisation.
Introduction to role:
We are seeking an experienced Process Chemistry Lead to join our Chemical Development laboratories in Dublin.
This is a highly visible scientific leadership role responsible for providing chemistry leadership across development, industrialisation and commercialisation activities. The Process Chemistry Lead acts as the primary scientific authority for process chemistry within cross-functional project teams and collaborates closely with analytical, process engineering, manufacturing, supply chain and quality colleagues to ensure successful technology delivery into APICOM manufacturing operations.
Unlike traditional development roles that operate through functional handovers, the Chemistry Lead remains accountable throughout the lifecycle of the process, ensuring knowledge continuity, technical rigour and efficient decision-making as projects progress from development through manufacturing and commercial supply.
The successful candidate will be expected to champion scientific excellence, innovation, process understanding and operational delivery whilst helping establish APICOM as a world-class API commercialisation capability.
The Process Chemistry Lead plays a critical role in delivering APICOM's vision of a seamless development-to-commercialisation pathway for AstraZeneca small molecule medicines. The position directly influences manufacturing readiness, launch success, supply continuity, product quality and process innovation, making a significant contribution to patient delivery, business performance and AstraZeneca's future manufacturing strategy.
Accountabilities:
Provide scientific leadership for small molecule API manufacturing processes from development through commercialisation.
Serve as the Chemistry Lead within integrated project teams, ensuring the process remains scientifically robust, scalable and commercially viable.
Own chemistry strategy across process optimisation, robustness, control strategy development and lifecycle management.
Drive deep process understanding through data-driven approaches, mechanistic understanding and risk-based development.
Support implementation of advanced manufacturing, process analytical technology (PAT) and digital process understanding tools.
Provide rapid technical leadership during manufacturing deviations, investigations and process performance assessments.
Support process validation activities and continued process verification programmes.
Drive initiatives that improve process capability, sustainability, productivity and supply robustness.
Work seamlessly across chemistry, analytical sciences, modelling, PAT, manufacturing, engineering, quality and regulatory functions.
Build strong partnerships with external suppliers, technology providers and academic collaborators where required.
Mentor and coach scientists within Chemistry and wider APICOM teams.
Contribute to development of working practices, standards and operating models within the Dublin laboratories.
Represent AstraZeneca externally through publications, conferences, scientific networks and collaborations where appropriate.
Essential Skills/Experience:
PhD in Organic Chemistry, Process Chemistry or a related discipline, or BSc/MSc with significant industrial experience.
Strong understanding of synthetic organic chemistry, reaction mechanisms and process development principles.
Demonstrated experience developing and scaling chemical processes for small molecule pharmaceutical manufacturing.
Experience translating laboratory-scale understanding into manufacturing-scale operations.
Strong problem-solving capability with the ability to balance scientific excellence and business needs.
Experience working within multidisciplinary project teams.
Experience working within a GMP technical space
Desirable Skills/Requirements:
Experience supporting technology transfer and industrialisation of API processes.
Experience working in late-stage development, launch preparation or commercial manufacturing support.
Familiarity with process validation, continued process verification and regulatory submissions.
Understanding of Process Analytical Technology (PAT), process modelling and digital manufacturing approaches.
Experience supporting highly potent or complex small molecule products.
Previous leadership or mentoring experience.
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
There are so many fantastic employee benefits that AstraZeneca can offer you: a competitive salary, private healthcare, a generous holiday allowance, phenomenal training and development opportunities, and much more.
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
Interested? Come and join our journey and apply today!
Date Posted
07-Aug-2026
Closing Date
22-Aug-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
We're transforming the future of healthcare by unlocking the power of what science can do for people, society and the planet. For more information, visit www.astrazeneca.com.
Community Guidelines: bit.ly/2MgAcio
Offices: 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, Cambridgeshire CB2 0AA, GB · Astraallen, Sodertalje, Stockholm County 152 57, SE
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How many Healthcare jobs are open in Dublin, Ireland right now?
There are currently 420 open healthcare positions in Dublin, Ireland listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Healthcare roles in Dublin, Ireland?
Companies currently hiring include Novartis, ICON plc, Allergan, Viatris Connect, AstraZeneca, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Healthcare jobs in Dublin, Ireland?
Yes — 191 of the 420 open healthcare positions offer remote or hybrid work (21 remote, 170 hybrid).
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