San Francisco, California, United States · Remote OK
$200k–$300k/yr
About Astera: Astera is a private foundation on a mission to steer science and technology toward an abundant future. We believe the coming years will bring an era of unprecedented scientific and technological advancement…
Skills: Machine learning, Computational biology, Generative AI, Reinforcement learning, Transformer architectures
San Francisco, California, United States · On-site
Applied Computational Biologist Valthos Inc. Valthos is an applied biological intelligence company. We build and deploy software and biological AI systems to safeguard humanity. The same AI architectures that enable self…
Skills: Computational biology, Bioinformatics, Genomics, Python, Machine learning
San Francisco, California, United States · On-site
$110k–$160k/yr
Product Growth Location: San Francisco (in-person, in-office, full-time ONLY) Compensation: $110K–$160K base + meaningful equity About Virio Virio is building the next-generation B2B GTM stack. Backed by investors and op…
Skills: Product growth, React, TypeScript, Full stack development, Experimentation
San Francisco, California, United States · Hybrid
$180k–$230k/yr
About Sift Sift is the data infrastructure platform for hardware engineering teams. Sift turns high-frequency telemetry into engineering insights for mission-critical systems. Teams use Sift to build and operate rockets,…
Skills: Distributed systems, Cloud infrastructure, Docker, Kubernetes, Go
San Francisco, California, United States · Hybrid
$150k–$200k/yr
What Your Day Will Look Like: As a construction project manager, you'll be responsible for leading projects through the construction phases, providing overall field contract administration and coordination for programs o…
Skills: Construction management, Contract administration, Project scheduling, Budget management, Construction inspection
San Francisco, California, United States · Hybrid
$125k–$175k/yr
About Sift Sift is the data infrastructure platform for hardware engineering teams. Sift turns high-frequency telemetry into engineering insights for mission-critical systems. Teams use Sift to build and operate rockets,…
Skills: Python, Rest Apis, Data Analysis, Data Visualization, Software Engineering
San Francisco, California, United States · Hybrid
$150k–$170k/yr
What Your Day Will Look Like: As an Interiors and Finishes Resident Engineer, you will oversee and manage interior construction scopes on-site, ensuring that design intent, quality standards, and project specifications a…
Skills: Construction management, Interior construction, Architectural finishes, Contract administration, Field inspection
San Francisco, California, United States · On-site
$194k–$267k/yr
We’re looking for a Senior Product Manager, Domain Team Enablement to join Procore’s Product & Technology Team within Datagrid, Procore's Agentic AI product. In this role, you’ll lead the platform strategy that enables o…
Skills: Product Management, Platform Strategy, AI Infrastructure, LLMs, Autonomous Agents
San Francisco, California, United States · Hybrid
$120k–$156k/yr
Our Mission SPAN is enabling electrification for all ⚡ We are a mission-driven company designing, building, and deploying products that electrify the built environment, reduce carbon emissions, and slow the effects of cl…
Skills: Product quality engineering, Manufacturing operations, PCBA manufacturing, Hardware validation, Failure analysis
San Francisco, California, United States · Hybrid
$255k–$300k/yr
About Abridge Abridge was founded in 2018 with the mission of powering deeper understanding in healthcare. Our AI-powered platform was purpose-built for medical conversations, improving clinical documentation efficiencie…
Skills: Python, LLM APIs, Prompting Strategies, LangChain, LlamaIndex
San Francisco, California, United States · On-site
$200k–$235k/yr
JLL empowers you to shape a brighter way. Our people at JLL are shaping the future of real estate for a better world by combining world class services, advisory and technology for our clients. We are committed to hiring …
Skills: Project management, Strategic leadership, Client relationship management, Commercial real estate, Team mentorship
San Francisco, California, United States · Hybrid
$128k–$156k/yr
At Early Warning, we’ve powered and protected the U.S. financial system for over thirty years with cutting-edge solutions like Zelle®, Paze℠, and so much more. As a trusted name in payments, we partner with thousands of …
Skills: Infrastructure As Code, CI/CD, Kubernetes, AWS, Terraform
San Francisco, California, United States · On-site
$170k–$205k/yr
Crusoe is on a mission to accelerate the abundance of energy and intelligence. As the only vertically integrated AI infrastructure company built from the ground up, we own and operate each layer of the stack — from elect…
Skills: Distributed systems, Cloud services, Python, Go, Java
San Francisco, California, United States · On-site
$140k–$200k/yr
Join the Sleep Fitness Movement At Eight Sleep, we’re on a mission to fuel human potential through optimal sleep. As the world’s first sleep fitness company, we’re redefining what it means to be well-rested and building …
Skills: Mechanical engineering, Consumer product design, Injection molding, Sheet metal forming, Sensor integration
San Francisco, California, United States · On-site
$240k–$300k/yr
Join the Sleep Fitness Movement At Eight Sleep, we’re on a mission to fuel human potential through optimal sleep. As the world’s first sleep fitness company, we’re redefining what it means to be well-rested and building …
Skills: Mechanical engineering, Product design, Electromechanical systems, Injection molding, Electronics integration
San Francisco, California, United States · On-site
$140k–$230k/yr
Join the Sleep Fitness Movement At Eight Sleep, we’re on a mission to fuel human potential through optimal sleep. As the world’s first sleep fitness company, we’re redefining what it means to be well-rested and building …
Skills: Hardware engineering, Program management, Product development, Project execution, Risk management
San Francisco, California, United States · Hybrid
$240k–$300k/yr
Join the Sleep Fitness Movement At Eight Sleep, we’re on a mission to fuel human potential through optimal sleep. As the world’s first sleep fitness company, we’re redefining what it means to be well-rested and building …
Skills: Mechanical engineering, Product design, Electromechanical systems, Team leadership, Hardware development
San Francisco, California, United States · Hybrid
$175/hr–$250/hr
What Your Day Will Look Like: As a transit rail phase execution construction manager, you will plan, coordinate, and execute complex transit rail construction phases for Bay Area Rapid Transit (BART) capital projects. Yo…
Skills: Construction management, Transit rail infrastructure, Project scheduling, Cost control, Contract administration
San Francisco, California, United States · On-site
$135k–$242k/yr
Job Requisition ID # 26WD98421 Position Overview At Autodesk, we do what no other company can: we help our customers design and make anything. The Experience Foundations team at Autodesk plays a critical role in designin…
Skills: Data science, Applied ML, Predictive modeling, Product analytics, User behavior modeling
San Francisco, California, United States · Hybrid
$124k–$155k/yr
About the team Turo is searching for a highly motivated and versatile Security Engineer to support and execute our efforts in securing enterprise systems and data through the daily operation, administration, and implemen…
Skills: Zero Trust, Email security, Data Loss Prevention, Endpoint security, Identity governance
San Francisco, California, United States • Remote OK
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
Drive core research by developing and executing scientific vision while designing reinforcement learning feedback loops for biological models. Collaborate with the experimental team to bridge wet and dry lab efforts and architect robust model training infrastructure.
Requires a PhD in machine learning, computational biology, or a related field with at least 1-2 years of post-PhD experience. Candidates must have hands-on experience training models from scratch and familiarity with modern generative AI and reinforcement learning algorithms.
Astera is a private foundation on a mission to steer science and technology toward an abundant future. We believe the coming years will bring an era of unprecedented scientific and technological advancement as exponential progress in AI converges with central advances in other fields to dramatically accelerate innovation. This inflection point provides an unparalleled opportunity to fundamentally rethink the institutions, systems, and tools that drive scientific progress.
Unlike traditional non-profit research organizations, projects supported by Astera operate like high-velocity startups, allowing us to focus on ambitious goals, match structure to problem, and attract strong technical talent and leadership. You can read more about our mission, vision, and programming here.
Today's frontier biological AI models are trained almost entirely on static, pre-existing data. They are powerful pattern matchers, but lack feedback from real biology.
Polytope Bio is a residency project at Astera that is building the missing piece: a post-training engine that closes the loop between frontier AI models and high-throughput biology. Our work will power new applications in generative biology by aligning frontier AI models directly to experimental measurements of what actually folds, binds, and functions.
We are looking for a Senior/Staff AI Research Scientist to join our foundational team. You will be joining at the point of maximum leverage: early enough to influence the modeling approaches, experimental design, and training strategy. The project is resourced with significant compute, financial runway, and the ability to generate large-scale prospective biological datasets. The researcher in this role will work hands-on to develop and publish new reinforcement learning methods and generative AI models leveraging datasets created by our unique high-throughput biology platform.
While our immediate focus is on hands-on research and rapid execution, there is potential for the right candidate to evolve into a co-founding technical or leadership role in the event of a future spinout.
Drive core research: Work closely with the technical founder and team to develop and execute the scientific vision, develop cutting-edge modeling approaches, and iterate rapidly on new ideas.
Develop RL feedback loop: Design, implement, and improve model post-training methods that translate high-throughput biological measurements into direct reward signals for biological language models.
Hands-on engineering: You will work directly with the technical team to architect model training infrastructure and build, run, and debug models, training loops, and evaluation metrics.
Bridge wet/dry lab: Partner with the experimental team to ensure that what we measure in the lab and what the models learn are designed as a single, cohesive system.
Research Experience: PhD in machine learning, computational biology, or a related field, with a minimum of 1-2 years of post-PhD research or industry experience (accomplished researchers without a PhD are also encouraged to apply).
Model Training: You have trained models from scratch, not just fine-tuned or called APIs. You have owned real training runs, know where they break, and know how to debug them.
Modern Algorithms: Hands-on experience with generative diffusion models and/or transformer architectures.
Reinforcement Learning: Familiarity with modern reinforcement learning and preference-optimization methods for deep learning.
Builder mindset: A track record of strong research via publications, open-source work, shipped models, or equivalent evidence that you drive results. You are highly self-directed but thrive in a tight-knit, collaborative early-stage environment.
Entrepreneurial spirit: Comfort operating with ambiguity and a desire to build something new. You are excited to tackle hard problems and potentially transition into a technical co-founder in the future.
Familiarity with biological research (protein modeling, sequence models, structural biology, or adjacent areas).
Experience building and scaling training infrastructure on large GPU clusters.
Preference for candidates able to co-locate in NYC or SF Bay Area. Remote work is possible for the right candidate.
Compensation: Base salary of $200,000 to $300,000 during the residency.
Upside: The potential to evolve into a co-founding technical role in a future spinout, contingent on project success and mutual fit.
Scientific Impact: Authorship of high-impact open-source datasets, methods, and models
Resources: Significant secured runway and dedicated GPU resources.
Unique Environment: A rare combination of frontier ML work directly coupled to a purpose-built, high-throughput experimental engine.
Comprehensive Benefits: Full benefits package including health insurance, a company sponsored retirement plan, vision, dental, and more.
We empower visionary, high-leverage science and technology projects with the capacity to create transformative progress.
Astera Institute was created to bring humanity the greatest imaginable good in the most efficient possible way. By incubating high leverage ideas in their earliest stages, Astera seeks to effect change at a systemic level via entrepreneurial experimentation. We focus on overlooked areas and invest in founders who can jumpstart initiatives and create a snowball effect.
Offices: Berkeley, CA, US
Based on 2731 listings with disclosed salaries, most engineering jobs in San Francisco, CA pay between $130k–$285k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 3,547 open engineering positions in San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include OpenAI, San Francisco Department of Public Health, Anthropic, Amazon, Salesforce, among others. Browse the listings above to see every active employer.
Yes — 1722 of the 3547 open engineering positions offer remote or hybrid work (365 remote, 1357 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
