Radical NumericsSan Francisco, California, United States · On-site
About Us Radical Numerics is an AI research lab building general biological intelligence. Our mission is to master the code of life, and our purpose is to reduce human suffering. Our team created Evo, and started the fie…
Skills: Backend Engineering, Distributed Systems, ML Inference, API Design, Python
San Francisco, California, United States · On-site
Overview We're seeking a Field Operations Leader to take our newest robot deployments from day-one rollout to smooth, high-throughput operation. Early deployments are where the hardest and most valuable problems live: yo…
Skills: Operational Ramp, Root Cause Analysis, Robotics Deployment, Physical Workflow Optimization, Project Management
San Francisco, California, United States · On-site
The Department of Neurological Surgery at UCSF is home to leading physicians and scientists dedicated to treating patients with neurosurgical disorders and to the search for better therapies and cures. Our mission is to …
Skills: Clinical Research Coordination, Patient Recruitment, Data Management, IRB Protocol Submission, HIPAA Compliance
San Francisco, California, United States · On-site
Company Background Specter's mission is to help automate the physical world. Today, we build video sensors with state-of-the-art AI agents that answer any question, anywhere in their environments. Our systems can automat…
Skills: Full-cycle Enterprise Sales, Outbound Prospecting, Pipeline Generation, Value Based Selling, Technical Pitching
San Francisco, California, United States · Hybrid
$210k–$284k/yr
About LiveKit LiveKit is building the infrastructure layer for the voice-driven era of computing. Our platform gives developers everything they need to build, test, deploy, scale, and observe agents in production. Founde…
Skills: Developer Advocacy, Community Engagement, Event Planning, Public Speaking, Technical Communication
San Francisco, California, United States · On-site
$300k–$330k/yr
About Anyscale: At Anyscale, we're on a mission to democratize distributed computing and make it accessible to software developers of all skill levels. We’re commercializing Ray, a popular open-source project that's crea…
Skills: Engineering Leadership, Technical Support, Customer Escalation Management, Distributed Systems, Cloud Infrastructure
San Francisco, California, United States · On-site
$140k–$220k/yr
Max AI – Stripe for Healthcare Max AI is the World’s first human-free, fully-autonomous medical billing AI agent. Many startups are attempting to attack this problem because the market is so big — $350B/yr. We have the b…
Skills: TypeScript, Nestjs, Python, Django, Nextjs
San Francisco, California, United States · Remote OK
$130k–$180k/yr
Sunlight reflection may be the only available option, alongside dramatic emissions reductions, adaptation, and rapid scaling of carbon removal, to rapidly limit many climate impacts over the coming decades. But we don’t …
Skills: Data Assimilation, Inverse Modeling, Aerosol Microphysics, Python, Uncertainty Quantification
San Francisco, California, United States · On-site
$150k–$250k/yr
Max AI – Stripe for Healthcare Max AI is the World’s first human-free, fully-autonomous medical billing AI agent. Many startups are attempting to attack this problem because the market is so big — $350B/yr. We have the b…
Skills: Machine Learning, Natural Language Processing, Python, Tensorflow, Pytorch
San Francisco, California, United States · On-site
$62k–$83k/yr
Who we are Atoms is building the machines that power the next era of progress. Over the last decade, software has transformed the digital world. But the physical world, where food is made, minerals are mined, goods are m…
Skills: Procurement, Purchase Order Processing, Vendor Management, Supply Chain Management, ERP Systems
San Francisco, California, United States · On-site
$62k–$83k/yr
Who we are Atoms is building the machines that power the next era of progress. Over the last decade, software has transformed the digital world. But the physical world, where food is made, minerals are mined, goods are m…
Skills: Procurement, Purchase Order Processing, Vendor Management, Supply Chain Management, ERP Systems
San Francisco, California, United States · On-site
$135k–$150k/yr
Job Overview The Director of Engineering is responsible for overseeing all aspects of the hotel's maintenance operations, ensuring compliance with safety regulations, internal audits, and Crescent standards. This role fo…
Skills: Preventative Maintenance, HVAC Management, Vendor Management, Budgeting, Team Leadership
San Francisco, California, United States · On-site
$160k–$230k/yr
About the Role Together is hiring a Senior Product Engineer to join our central Product Engineering team and embed day-to-day with the Commerce engineering team. You will own the product UI surface for Together AI’s most…
Skills: React, TypeScript, Next.js, Tailwind CSS, Shadcn/ui
San Francisco, California, United States · Remote OK
$150k–$200k/yr
AI Systems Engineer ASG HoldCo | Engineering | Fully Remote Company Description ASG is backed by Alpine Investors and acquires market-leading vertical SaaS companies, accelerating their transformation into AI-native plat…
Skills: AI Workflow Automation, Enterprise Integrations, Security Architecture, Agentic Systems, Identity And Access Management
San Francisco, California, United States · On-site
$50/hr–$60/hr
About The Role We are seeking a Production Engineer with solid Python experience to join our growing engineering team. You will monitor, maintain, and troubleshoot production systems and services, respond to incidents, a…
Skills: Python, Production Support, Automation, Troubleshooting, CI/CD
San Francisco, California, United States · Hybrid
$117k–$146k/yr
For over a century, the Workers' Compensation Insurance Rating Bureau of California (WCIRB) has been California's trusted, objective provider of actuarially based information and research, advisory pure premium rates and…
Skills: .NET Core, Azure, C#, SQL Server, ASP.NET
San Francisco, California, United States · Hybrid
$231k–$318k/yr
About Faire Faire is a technology wholesale platform built on the belief that the future is local. Independent retailers around the globe collectively represent a multi-hundred-billion-dollar wholesale market that has hi…
Skills: Machine Learning, Artificial Intelligence, Search Systems, Recommendation Systems, Large Language Models
San Francisco, California, United States · Hybrid
$148k–$203k/yr
Our mission at Oura is to empower every person to own their inner potential. Our award-winning products help our global community gain a deeper knowledge of their readiness, activity, and sleep quality by using their Our…
Skills: SQL, Python, Data Modeling, AWS, Databricks
San Francisco, California, United States · On-site
$173k–$203k/yr
Our mission at Oura is to empower every person to own their inner potential. Our award-winning products help our global community gain a deeper knowledge of their readiness, activity, and sleep quality by using their Our…
Skills: Okta, Identity And Access Management, Endpoint Engineering, Infrastructure As Code, Terraform
San Francisco, California, United States · Hybrid
$136k–$190k/yr
About Us: We love going to work and think you should too. Our team is dedicated to trust, customer obsession, agility, and striving to be better everyday. These values serve as the foundation of our culture, guiding our …
Skills: IT Infrastructure, Software Development, Cloud-Native Architecture, Containerization, Observability
Radical Numerics
San Francisco, California, United States • On-site
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
Build and maintain the inference APIs, compute orchestration layers, and developer-facing products for the Omnii genome language model. Focus on optimizing throughput, latency, and cost for genome-scale workloads while ensuring reliability and security.
Requires extensive experience building production-scale distributed systems and shipping models as a service. Proficiency in Python and a typed language is necessary, along with strong product judgment for API design.
Radical Numerics is an AI research lab building general biological intelligence. Our mission is to master the code of life, and our purpose is to reduce human suffering.
Our team created Evo, and started the field of generative genomics. Our work was featured on the cover of Science, and presented by our CEO on the main stage of TED2025. Evo was used to create the first AI gene therapy tool CRISPR-Cas9, and the first AI whole genome from scratch. Evo 2, featured in Nature, is the largest fully open source AI project across any domain.
Radical Numerics is bringing the rigor of distributed systems, model architecture, and numerics research to the challenges of biology. We’ve redesigned the foundation model training stack to turn the world’s raw scientific data (e.g. biological sequences, experiments, and physical processes), into intelligible, generative models that can expand and accelerate what humanity can understand, design, and cure.
The same generative breakthroughs that enable life-saving cures also lowers the barrier to creating engineered threats and AI-generated bioweapons. We believe these forces are inseparable. Radical Numerics was founded to develop both the power to design and the responsibility to defend.
As a Member of Technical Staff, ML Product Engineer, this role owns the layer between the models and the people using them: the APIs, batch and compute systems, and services that make inference fast, reliable, and cheap at genome scale. You would build for our scientists and for the partners and developers who build on Omnii, our next-generation genome language model.
You care about throughput, latency, cost, and uptime, and you have real opinions about what a good developer experience feels like. The platform you build is how Omnii reaches the people using it to advance human health and biosecurity.
This role sits close to our product and data-partnership functions and our modeling team. You translate between what the science needs, what partners can consume, and what the infrastructure can deliver.
Build the inference APIs behind Omnii: real-time serving plus large batch scoring for genome- and variant-scale workloads, where a single job can be millions of sequences, latency-tolerant and cost-sensitive.
Design the compute and orchestration layer: job queues, autoscaling GPU inference, retries, fault tolerance, and the observability to run all of it against real SLAs.
Build the developer-facing product: the API surface, SDKs, and documentation that let an outside team depend on Omnii without hand-holding.
Drive down cost and latency per inference, and make performance predictable enough to price and guarantee.
Package the platform to run inside partner environments that cannot let data leave, including on-prem and air-gapped installs.
Work directly with our scientists and partners to shape the API around real inference workloads.
You have built and operated backend or distributed systems at production scale, and you owned their reliability.
You have shipped a model as a service that other people depended on. You think in inference, serving, and throughput.
You have built asynchronous or batch job systems at scale. Genome-scale workloads should feel like familiar ground.
You write production code in Python and at least one typed language, and you are comfortable with containers and infrastructure as code.
You have product judgment. You can decide what to expose, what to hide, and how an API should feel to the person calling it.
You operate well with ambiguity and want the ownership of an early technical role.
GPU inference internals: vLLM, TensorRT-LLM, or Triton, with hands-on performance tuning.
Experience deploying software into locked-down environments such as enterprise VPC, on-prem, or air-gapped.
Familiarity with genomics or computational biology, or a real appetite to learn it fast.
Experience standing up an external API product from the first endpoint forward.
Radical Numerics is committed to equal employment opportunity and does not discriminate in any employment opportunities or practices based on an individual's race, color, creed, gender (including gender identity and gender expression), religion (all aspects of religious beliefs, observance or practice, including religious dress or grooming practices), marital status, registered domestic partner status, age, national origin or ancestry (including language use restrictions and possession of a driver’s license issued under California Vehicle Code section 12801.9), natural hair, physical or mental disability, political affiliation, medical condition (including cancer or a record or history of cancer, and genetic characteristics), sex (including pregnancy, childbirth, breastfeeding or related medical condition), genetic information, sexual orientation, military and veteran status or any other consideration made unlawful by federal, state, or local laws. It also prohibits unlawful discrimination based on the perception that anyone has any of those characteristics, or is associated with a person who has or is perceived as having any of those characteristics.
Radical Numerics participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.
Based on 2822 listings with disclosed salaries, most engineering jobs in San Francisco, CA pay between $130k–$284k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 3,686 open engineering positions in San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include OpenAI, Anthropic, San Francisco Department of Public Health, Crusoe, Pinterest, among others. Browse the listings above to see every active employer.
Yes — 1854 of the 3686 open engineering positions offer remote or hybrid work (372 remote, 1482 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
