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$108k–$143k/yr
Full-time
bachelor degree
Posted 1d ago
~40 hrs/week
Responsibilities
The role involves supporting the scale-up, manufacturing, and characterization of lipid nanoparticle-based nucleic acid formulations. You will also maintain documentation, perform stability studies, and investigate process discrepancies to ensure robustness.
Requirements
Candidates must have 1-2 years of experience in a life science or pharmaceutical setting and a bachelor's degree in a relevant scientific field. Hands-on expertise with nanoparticle formulations and analytical instrumentation is required.
Full job description
WHY WORK FOR ARCTURUS?
Founded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a clinical-stage mRNA medicines and vaccines company with enabling technologies: (i) LUNAR® lipid-mediated delivery, (ii) STARR™ mRNA Technology and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes self-replicating mRNA vaccine programs for SARS-CoV-2 (COVID-19) and Influenza, and other programs to potentially treat Ornithine Transcarbamylase (OTC) Deficiency, Cystic Fibrosis, Cardiovascular Disease along with partnered programs including Glycogen Storage Disease Type 3, Hepatitis B Virus, and non-alcoholic steatohepatitis (NASH). Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics.
Arcturus’ technologies are covered by its extensive patent portfolio (192 patents and patent applications, issued in the U.S., Europe, Japan, China and other countries). Arcturus’ commitment to the development of novel RNA therapeutics has led to collaborations with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., Takeda Pharmaceutical Company Limited, CureVac AG, Synthetic Genomics Inc., Duke-NUS, and the Cystic Fibrosis Foundation.
Arcturus Therapeutics is presently recruiting outstanding candidates with experience in the field of mRNA technologies and nanoparticle sciences.
Our corporate culture is dynamic, diverse, and creative. We value collaboration and teamwork. We seek individuals to join us with a genuine passion for the science behind helping to cure disease and improve the lives of patients.
THE OPPORTUNITY
In this role, you will support scale-up, manufacturing, and characterization of lipid nanoparticle-based nucleic acid formulations to support our emerging research pipeline. Our ideal candidate will bring a willingness to learn and contribute to our formulation production and purification processes.
WHAT YOU WILL CONTRIBUTE
Develop and nucleic based formulations including complex nanoparticle formulations.
Prepare and characterize dose formulations for various in vitro and in vivo studies.
Perform process-related investigations, identify root causes of process/manufacturing discrepancies, evaluate systems for trends and adverse findings, and implement appropriate steps to ensure process robustness.
Perform formulation stability studies, contact material compatibility, and stability in the study, in-use compatibility study, and accelerated stability studies.
Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs), and other manufacturing related documentation.
Prepare technical reports and presentations which summarize procedures, study results, and data interpretation as needed.
Deliver high-quality results in an accurate and in a time sensitive manner
Maintain accurate and timely records
Perform other activities as needed
WHAT WE SEEK
1-2 years of related experience in life science, pharmaceutical company or academic lab setting.
Experience with nucleic acid-based formulations, complex/nanoparticle formulations, and knowledge of tangential flow filtration.
Hands-on expertise working with liquid, frozen, and/or lyophilized dosage forms.
Hands-on experience or working knowledge of one or more analytical instrumentation, such as HPLC, LC-MS, Akta, Dynamic Light Scattering, Plate reader, etc.
Familiarity with stages of drug product development and cGMP concept, knowledge of analytical methods for testing lipid nanoparticles and understanding of the in-vitro and in-vivo experiments used for screening of nanoparticle formulation highly preferred.
Comfortable working in a highly innovative, changing, fast-paced environment is required.
Ability to work overtime, as required, including weekends.
Willingness and motivation to learn new techniques and protocols
EDUCATION
Bachelor’s degree in chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, Bioengineering or other related science field;
A messenger RNA medicines company focused on the development of liver and respiratory rare disease therapeutics
Industry
Biotechnology Research
Company size
51-200 employees
Founded
2013
Headquarters
San Diego, California
LinkedIn followers
20,339
Total funding
$490M
Founded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a messenger RNA medicines company focused on the development of liver and respiratory rare disease therapeutics with enabling technologies: (i) LUNAR® lipid-mediated delivery, (ii) STARR® mRNA technology (sa-mRNA) and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus developed KOSTAIVE®, the first self-amplifying messenger RNA (sa-mRNA) COVID vaccine in the world to be approved. Arcturus has an ongoing global collaboration with CSL Seqirus, U.S. BARDA for pandemic flu and a joint venture in Japan, ARCALIS, focused on the manufacture of mRNA vaccines and therapeutics. Arcturus’ pipeline includes RNA therapeutic candidates to potentially treat cystic fibrosis (CF) and ornithine transcarbamylase (OTC) deficiency along with its partnered mRNA vaccine programs for SARS-CoV-2 (COVID-19) and influenza. Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA (siRNA), circular RNA, antisense RNA, self-amplifying RNA, DNA, and gene editing therapeutics. Arcturus' technologies are covered by its extensive patent portfolio (over 500 patents and patent applications in the U.S., Europe, Japan, China, and other countries). For more information, visit www.ArcturusRx.com. Please connect with us on X and LinkedIn.
Offices: 10285 Science Center Dr, San Diego, California 92121, US
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