Aktis Oncology, Inc. is a clinical-stage oncology company focused on expanding the breakthrough potential of targeted radiopharmaceuticals to large patient populations, including those not addressed by existing platform …
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$108k–$149k/yr
Full-time
bachelor degree, postgraduate degree
Posted 21d ago
~40 hrs/week
Responsibilities
The Scientist/Senior Scientist will work in cross-functional teams to identify and develop novel oncology therapies through early discovery and lead optimization. They will independently apply cutting-edge methodologies to design and execute in vitro pharmacology experiments to advance company objectives.
Requirements
Candidates must hold a Ph.D. in a biotechnology-related field or a Bachelor's/Master's degree with significant industry experience. Expertise in molecular and biochemical techniques, cell culture, and assay development is required to support drug discovery programs.
Full job description
Aktis Oncology, Inc. is a clinical-stage oncology company focused on expanding the breakthrough potential of targeted radiopharmaceuticals to large patient populations, including those not addressed by existing platform technologies. Aktis’ most-advanced program, AKY-1189, is a miniprotein radioconjugate targeting Nectin-4, with multi-indication potential across multiple tumor types, including locally advanced or metastatic urothelial cancer, breast cancer, non-small cell lung cancer, colorectal cancer, cervical cancer, and head and neck cancer. Aktis’ second pipeline program, AKY-2519, is a miniprotein radioconjugate targeting B7-H3 expressing tumors, including prostate, lung, and other solid tumors. Aktis has a strategic collaboration with Eli Lilly and Company to leverage its miniprotein platform to develop novel radioconjugates outside of Aktis’ proprietary pipeline.
The Scientist/Senior Scientist within the Molecular Pharmacology group will work in cross-functional teams to identify and develop novel therapies to treat targeted patient populations within multiple oncology indications. They will independently apply and develop cutting-edge tools and methodologies to enable advancement of company objectives with a focus on early discovery and lead optimization activities. Through project leadership and experimental activities, the team member will find solutions to program-related challenges in order to advance programs as part of the Biology Team.
BACKGROUND / TRAINING
Ph.D. in a biotechnology-related field (e.g. pharmacology, biology or similar disciplines) or Bachelor’s or Master’s degree in similar disciplines with a strong track record of industry-related experience and accomplishments. Experience in oncology or cancer biology preferred, but not required.
Minimum of 2 years of biopharmaceutical research experience in drug discovery and/or translational research with Ph.D. or 5+ years of experience required with Bachelor’s or Master’s degree.
EXPERIENCE / ACCOMPLISHMENTS
Experience with application and development of basic science methodologies to support complex strategies and enable advancement of Company objectives.
Demonstrated success with the development, execution and interpretation of in vitro screening experiments to explore therapeutic potential of drug targets and drive development programs.
Strong technical background in planning, designing, executing and documenting pre-clinical in vitro pharmacology experiments in order to evaluate target biology and characterize the efficacy and safety of development candidates
Required expertise includes:
Target engagement assay development
Mammalian cell culture / cell line engineering
Knowledge of medium-throughput cell-based assays and in vitro pharmacology (e.g. ligand-binding assays)
Common molecular and biochemical techniques (DNA/RNA isolation, qPCR, Western, ELISA, antibody characterization and QC, etc.)
Preferred expertise includes:
Development of physiologically relevant in vitro cell and tissue culture systems; primary cell culture considered a plus
Experience driving screening funnels to evaluate candidate molecules through lead optimization workflows
Flow cytometry
Mechanism of action studies
Demonstrated success in the areas of lead discovery and optimization along with a track record of integration with matrixed project teams
Demonstrated ability to gather relevant information systematically, break down problems into simple components and make sound decisions
Willingness to take on new challenges and build a culture of rigor and data-driven decision-making to bring novel therapies to the clinic
Effectively communicates and collaborates with other R&D team members and collaborators to progress development candidate compounds
Demonstrated high standards for scientific rigor, team behaviors, excellence and building a culture of innovation that is fully aligned with company objectives
Demonstrated tenacity and drive for enterprise benefit
Excellent interpersonal and collaborative skills
Thrives in a fast-paced, ever-changing growth environment with the ability to work independently
Proven demonstration of transparent communication and fostering open and diverse debate
Ability to work with agility and manage ambiguity
Personifies positive energy and exemplifies respect
Aktis Oncology is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
Expanding the breakthrough potential of targeted radiopharmaceuticals to large cancer patient populations.
Industry
Biotechnology Research
Company size
51-200 employees
LinkedIn followers
12,981
Total funding
$331M
Aktis Oncology (Nasdaq: AKTS) is a clinical-stage oncology company focused on expanding the breakthrough potential of targeted radiopharmaceuticals to large patient populations, including those not addressed by existing platform technologies.
The company has developed a proprietary miniprotein radioconjugate platform designed to selectively deliver the tumor-killing properties of radioisotopes to targeted tumors, while being rapidly cleared from normal organs and tissues to minimize systemic radiation exposure. Aktis’ most advanced pipeline program targets Nectin-4, a miniprotein radioconjugate with multi-indication potential across multiple tumor types. The company also maintains a strategic collaboration with Eli Lilly and Company to develop novel anticancer radiopharmaceuticals for targets outside of Aktis’ proprietary pipeline.
Based on 336 listings with disclosed salaries, most engineering jobs in Durham, NC pay between $54k–$250k per year. Individual offers vary with seniority, company size, and specialization.
How many Engineering jobs are open in Durham, NC right now?
There are currently 734 open engineering positions in Durham, NC listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Engineering roles in Durham, NC?
Companies currently hiring include NVIDIA, Fidelity Investments, Hewlett Packard Enterprise, KBI Biopharma, PowerSecure, Inc., among others. Browse the listings above to see every active employer.
Are there remote or hybrid Engineering jobs in Durham, NC?
Yes — 208 of the 734 open engineering positions offer remote or hybrid work (60 remote, 148 hybrid).
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