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Full-time
postgraduate degree
Posted 3d ago
~40 hrs/week
Responsibilities
The Postdoctoral Associate will develop and maintain intestine-based Organs-on-Chips to study the oral delivery and systemic distribution of therapeutic agents. They will also collaborate with multidisciplinary teams to integrate data across platforms and contribute to manuscript and grant preparation.
Requirements
Candidates must hold a Ph.D. in Pharmacology, Biomedical Engineering, Physiology, or a related field. Experience with human intestinal models, experimental design, and quantitative analysis is required.
Full job description
Postdoctoral Associate #3 – Benam Lab – Human Intestinal Models and Oral Delivery Modeling
The Benam Lab (https://www.benamlab.net/) at the University of Pittsburgh Departments of Medicine and Bioengineering is seeking a highly motivated Postdoctoral Associate to join an interdisciplinary research program focused on developing and applying advanced human-relevant in vitro models to study systemic biology and therapeutic responses. The successful Candidate will contribute to cutting-edge research at the interface of microphysiological systems (Organs-on-Chips), pharmacology, and translational biomedical science.
This position emphasizes the use of intestine-based, interconnected microphysiological systems to model the oral delivery, absorption, and systemic distribution of therapeutic agents under physiologically relevant conditions, with integration into multi-organ platforms to enable pharmacokinetic and pharmacodynamic (PK/PD) analyses.
Responsibilities
The Postdoctoral Associate will play a key intellectual and technical role in the research program. Responsibilities include:
Establish and maintain intestine-based Organs-on-Chips using primary or relevant epithelial cell systems
Design and execute studies evaluating oral delivery, absorption, and transport of therapeutic agents under controlled experimental conditions
Perform and optimize assays to assess epithelial barrier function, transport dynamics, and tissue responses
Support multi-organ integration studies to enable PK/PD analyses across interconnected in vitro systems
Contribute to development and refinement of experimental workflows to enhance reproducibility and physiological relevance
Collaborate with multidisciplinary teams to integrate intestinal data with complementary organ systems and analytical platforms
Support data generation, analysis, and interpretation, including integration of findings across studies
Maintain accurate and detailed documentation of experimental procedures and results
Contribute to preparation of manuscripts, reports, and grant applications
Mentor trainees and assist in training of laboratory personnel as needed
Qualifications
Required:
Ph.D. in Pharmacology, Biomedical Engineering, Physiology, or a related field
Experience with human intestinal cells and models, and/or intestinal transport biology
Strong background in experimental design and quantitative analysis
Strong analytical, organizational, and problem-solving skills
Ability to work independently and collaboratively in a multidisciplinary research environment
Strong written and verbal communication skills
Preferred:
·Experience with intestinal models, barrier function assays, or drug absorption studies
·Familiarity with pharmacokinetic/pharmacodynamic (PK/PD) concepts
·Experience with Organs-on-Chips or integrated tissue models
·Experience working in interdisciplinary teams integrating biology, engineering, and pharmacology
UPMC is a world-renowned, nonprofit health care provider and insurer committed to delivering exceptional, people-centered care and community services. Headquartered in Pittsburgh and affiliated with the University of Pittsburgh Schools of the Health Sciences, UPMC is shaping the future of health through clinical and technological innovation, research, and education. Dedicated to advancing the well-being of our diverse communities, we provide nearly $2 billion annually in community benefits, more than any other health system in Pennsylvania. Our 100,000 employees — including more than 5,000 physicians — care for patients across more than 40 hospitals and 800 outpatient sites in Pennsylvania, New York, and Maryland, as well as overseas. UPMC Insurance Services covers more than 4 million members, providing the highest-quality care at the most affordable price. To learn more, visit UPMC.com.
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