Pittsburgh, Pennsylvania, United States · On-site
A highly motivated full-time postdoctoral associate is sought in Dr. Yuanyuan Chen’s laboratory at the Department of Ophthalmology, University of Pittsburgh. The Chen Lab uses pharmacological and molecular biological met…
Skills: Pharmacology, Biochemistry, Rodent Retinal Techniques, OCT, ERG
Pittsburgh, Pennsylvania, United States · On-site
The University of Pittsburgh School of Medicine, Department of Neurology, and the University of Pittsburgh Medical Center are seeking a BC/BE neurologist at the level of Assistant Professor, Associate Professor, and Prof…
Skills: Neurology, Clinical Research, Bench Research, Medical Teaching, Outpatient Care
Pittsburgh, Pennsylvania, United States · On-site
Serves as a primary contact for faculty, staff, union, and students regarding all payroll actions and issues and provides support and guidance. Reviews and corrects record changes, payroll actions, employment forms, and …
Skills: Payroll Administration, Onboarding, Recruitment, Data Entry, Compliance
Pittsburgh, Pennsylvania, United States · On-site
The University of Pittsburgh, Department of Medicine, Division of Endocrinology and Metabolism is seeking an Assistant Professor in the appointment stream to serve as Longitudinal Educator, whose focus is to help the stu…
Skills: Medical Education, Clinical Teaching, Endocrinology, Metabolism, Curriculum Development
Pittsburgh, Pennsylvania, United States · On-site
$18/hr–$25/hr
About Integrated Health 21 Integrated Health 21 (IH21) is a leading provider of worksite wellness screenings and vaccination clinics across the continental United States. Headquartered in Pittsburgh, PA, with offices in …
Skills: Phlebotomy, Venipuncture, Fingerstick Blood Collection, Blood Pressure Measurement, Anthropometric Measurements
Pittsburgh, Pennsylvania, United States · Remote OK
This role qualifies for a remote work arrangement within our 7 state footprint (PA, OH, MI, WV, VA, MD, NC). This position offers a base salary range of $61,843.00 - $108,497.00 per year, depending on experience and qual…
Skills: System Administration, Enterprise System Deployment, System Maintenance, Problem Determination, Capacity Planning
Pittsburgh, Pennsylvania, United States · On-site
$300k–$415k/yr
Job Summary: The Managing Director, AI & Digital Innovation Delivery is responsible for leading AI solution delivery strategy, engineering governance, and execution across the DT&I portfolio. This role provides oversight…
Skills: AI Strategy, AI/ML Engineering, Azure AI Services, SDLC Governance, DevOps
Pittsburgh, Pennsylvania, United States · On-site
UPMC Mercy is hiring a Full Time Teacher to support the Child Development Center! The Child Development Center is open Monday-Friday from 6:30am-6pm. This position works rotating 8 hour shifts varying from 6:30am to 6:00…
Skills: Early Childhood Education, Child Development, Classroom Management, Curriculum Planning, Parent-Teacher Communication
Pittsburgh, Pennsylvania, United States · On-site
UPMC Mercy is hiring a Full Time Assistant Teacher to support the Child Development Center! The Child Development Center is open Monday-Friday from 6:30am-6pm. This position works varied 8 hour shifts varying from 6:30am…
Skills: Child Development, Curriculum Planning, Classroom Management, Parent Communication, Team Teaching
Pittsburgh, Pennsylvania, United States · Hybrid
UPMC Corporate Facilities Engineering and Maintenance is hiring a Facilities Dispatcher to join our team! This role will work on varied days, which includes assigned weekends and holidays. The position will work daylight…
Skills: Call Center Operations, Dispatching, CMMS, Microsoft Office, Emergency Response
Pittsburgh, Pennsylvania, United States · On-site
$65k–$75k/yr
Location: Pittsburgh, Pennsylvania Position Title: CHEF MANAGER, PITTSBURGH, PA Pay Grade: 11 Reports To: General Manager Salary: $65,000 - $75,000 Other Forms of Compensation: Medical, Dental & Vision insurance, 401K, P…
Skills: Culinary management, Inventory management, Ordering and receiving, P&L accountability, Menu development
Pittsburgh, Pennsylvania, United States · On-site
$12/hr–$17/hr
About Us: Want to bring the “care” back to the vision care industry? We're looking for charismatic types who are ready to be the heart of our brand. Whether it's a friendly voice over the phone, or a welcomin…
Skills: Optical Knowledge, Sales, Customer Service, Patient Care, Eyewear Dispensing
Pittsburgh, Pennsylvania, United States · On-site
Standard Air has grown through the past 70 years by serving the commercial and residential HVAC contractors with quality pre-sale application and post-sales support and a large inventory of equipment and parts. Our emplo…
Skills: Accounts Payable, General Ledger, Journal Entries, Sales and Use Tax Filing, Bank Reconciliation
Pittsburgh, Pennsylvania, United States · On-site
$12/hr–$17/hr
About Us: Want to bring the “care” back to the vision care industry? We're looking for charismatic types who are ready to be the heart of our brand. Whether it's a friendly voice over the phone, or a welcomin…
Skills: Preliminary Testing, Patient Records Management, Optics, Customer Service, Eye Health Knowledge
Pittsburgh, Pennsylvania, United States · On-site
UPMC Mercy is seeking a Floor & Project Technician to join our team! In this role, you will maintain all types of floor areas through the process of stripping/refinishing hard surface floors and shampooing carpeted areas…
Skills: Floor Stripping, Floor Refinishing, Carpet Shampooing, Sanitization, Equipment Maintenance
Pittsburgh, Pennsylvania, United States · On-site
About the Daniel G. and Carole L. Kamin Science Center Kamin Science Center is dedicated to inspiring learning and curiosity by connecting science and technology with everyday life. By making science both relevant and fu…
Skills: Customer Service, Cash Handling, Communication, Point-of-Sale Systems, Safety Briefing
Pittsburgh, Pennsylvania, United States · On-site
About the Daniel G. and Carole L. Kamin Science Center Kamin Science Center is dedicated to inspiring learning and curiosity by connecting science and technology with everyday life. By making science both relevant and fu…
Skills: Mechanical Repair, Electrical Systems, Electric Vehicle Maintenance, Troubleshooting, Lead-Acid Batteries
Pittsburgh, Pennsylvania, United States · On-site
At OTH Hotels Resorts, our team is our number one asset. We strive to create a safe, positive, uplifting work environment for all and a culture that ignites a long-term career passion for hospitality and service. Our sha…
Skills: Guest Room Cleaning, Sanitization, Time Management, Attention To Detail, Customer Service
Pittsburgh, Pennsylvania, United States · On-site
We are Aaron’s - an industry leader in the sales and lease-to-own retail industry, known for quality brand names and superior customer service. We provide our team members with the opportunity to reach their full p…
Skills: Communication Skills, Electronics Knowledge, Customer Service, Vehicle Operation, Merchandise Installation
Pittsburgh, Pennsylvania, United States · On-site
Summary The primary purpose of this position is to direct all facets of business at HACP-operated sites. The incumbent will manage property management employees, including the Assistant Site Manager, ensure that all proc…
Skills: Property Management, Budget Management, Staff Supervision, Rent Collection, Lease Enforcement
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
The candidate will lead pharmacological studies on retinal degenerative diseases, focusing on methotrexate and nuclear speckle rejuvenation. Responsibilities include conducting research using cell cultures and rodent models, drafting first-author manuscripts, and assisting with lab management.
Requires a PhD in pharmacology, biochemistry, or pharmacy, or an MD with ophthalmology training. Candidates must have at least one year of experience in rodent retinal techniques or pharmacology skill sets and at least one first-author research article.
A highly motivated full-time postdoctoral associate is sought in Dr. Yuanyuan Chen’s laboratory at the Department of Ophthalmology, University of Pittsburgh. The Chen Lab uses pharmacological and molecular biological methods to study retinal degenerative diseases and to find new treatments. Specifically, the Chen Lab is looking for small molecules that upregulate protein homeostasis and those that mitigate retina immune responses. In particular, we use small molecule high-throughput screening, retina ex vivo culture, and in vivo mouse retinal morphology and physiology techniques to identify novel small molecules that repair defective homeostasis observed in cells with mutated rhodopsin. Further, the Chen lab is developing a new drug screening platform using retinal explants to find drugs that prevent retinal degeneration. We aim to discover the most effective and potent compounds, characterize their metabolism and effects in mouse models of eye diseases, and develop an efficacious and safe treatment regimen that can be further tested in large animals and clinical trials. The Chen lab publishes well in high impact journals including Nat Comm, JCI Insight, and Comm Biol et al. Dr. Chen’s lab is supported by NIH R01, Hillman Challenge Research Award, and the FFB TRAP Award. The translational research nature of this lab makes it an ideal place for candidates seeking a pharmaceutical career path. More information about the Chen Lab is here: https://ivy00chen.wixsite.com/chenlab
· Duties or Responsibilities
o The research to be performed is the pharmacological studies of retinal degenerative disease. The candidate will participate in two projects as the driving force: 1) the mechanism of actions of methotrexate in rescuing the function of retina with retinitis pigmentosa; 2) the pharmacological studies of nuclear speckle rejuvenation in retinitis pigmentosa. Additionally, the candidate is expected to participate in collaborative projects and their contributions will be recognized as a co-author. The research projects will utilize cell culture, retina explant culture and rodent models to investigate the efficacy, safety, mechanism of actions, and pharmacokinetics of drug candiates for treating retinal degeneration. The lab also investigates the disease mechanisms along the way of drug discovery and development.
o The postdoc candidate will perform research activities in a team with other lab members and collaborative teams. They will present their research at national/international conferences. They are expected to conduct research projects as a leading force, and draft their first-authored research manuscripts under supervision of the PI. They are encouraged to write applications for postdoctoral fellowships and career development grants.
o The postdoc candidate will develop leadership skills by helping the PI with lab management, training young scientists in the lab, editing IBC and IACUC protocols, maintaining and breeding animals, and ordering research materials.
o The postdoc candidate is expected to deliver at least one project to the extent equivalent or more than one first-authored research article, accepted in a solid journal such as FASEB J or higher, before leaving the lab.
· Expectations or Qualifications
Ph.D in pharmacology, biochemistry or pharmacy, or MD with Ophthalmology training. Have a minimum 1 year of experience in rodent retinal techniques including OCT, ERG, and retinal histology, and hold expertise in routine tissue culture, Western blots, and qPCR skills.
Alternatively, expertise in pharmacology skill sets, including treatment to rodents, pharmacokinetics using HPLC, efficacy and mechanism of action studies.
At least one first-author research article accepted by a mainstream journal.
· Opportunities Available
· The Department of Ophthalmology provides Biology in Vision and three other Vision and Hearing graduate certificate courses for the candidate to attend based on needs. The Chen lab supports trainees to attend national/international meetings when the candidate has sufficient data to present. The Chen lab also supports and has a successful record for trainees’ fellowship and travel awards. Dr. Chen strongly supports postdoctoral fellows’ career development towards academic independence or pharmaceutical jobs.
Life Changing Medicine.
UPMC is a world-renowned, nonprofit health care provider and insurer committed to delivering exceptional, people-centered care and community services. Headquartered in Pittsburgh and affiliated with the University of Pittsburgh Schools of the Health Sciences, UPMC is shaping the future of health through clinical and technological innovation, research, and education. Dedicated to advancing the well-being of our diverse communities, we provide nearly $2 billion annually in community benefits, more than any other health system in Pennsylvania. Our 100,000 employees — including more than 5,000 physicians — care for patients across more than 40 hospitals and 800 outpatient sites in Pennsylvania, New York, and Maryland, as well as overseas. UPMC Insurance Services covers more than 4 million members, providing the highest-quality care at the most affordable price. To learn more, visit UPMC.com.
Offices: US Steel Tower, 600 Grant Street, Pittsburgh, PA 15219, US
