South San Francisco, California, United States · On-site
About Human Longevity, Inc. (HLI) Human Longevity, Inc. (HLI) is a leader in precision health, combining genomics, advanced imaging, biomarker testing, and artificial intelligence to transform the future of proactive hea…
Skills: Python, SQL, Large Language Models, Retrieval-Augmented Generation, AI Agents
South San Francisco, California, United States · On-site
$22/hr–$35/hr
Benefits: 401(k) Bonus based on performance Dental insurance Employee discounts Health insurance Opportunity for advancement Profit sharing Vision insurance You're the first point of contact for customers walking through…
Skills: Wireless Sales, Customer Relationship Management, Consultative Selling, Needs Diagnosis, Prospecting
South San Francisco, California, United States · Hybrid
$170k–$200k/yr
Color Health is revolutionizing cancer care with the nation’s first Virtual Cancer Clinic, delivering high-quality, physician-led multidisciplinary care across all 50 states. Our innovative, guideline-based approach span…
Skills: Product Management, Business Operations Platforms, AI Integration, Roadmap Strategy, Cross-functional Leadership
South San Francisco, California, United States · On-site
$167k–$309k/yr
Principal Business Product Manager - Insights & Analytics (Targeting) Why Genentech We're passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a …
Skills: Product Management, Pharmaceutical Analytics, Agile Methodology, Stakeholder Management, Product Strategy
South San Francisco, California, United States · Hybrid
$183k–$225k/yr
At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees…
Skills: Windows Server, IIS, SQL Server, Docker, AWS
South San Francisco, California, United States · On-site
$190k–$316k/yr
About Neuralink: We are creating devices that enable a bi-directional interface with the brain. These devices allow us to restore movement to the paralyzed, restore sight to the blind, and revolutionize how humans intera…
Skills: Privacy Law, Healthcare Compliance, HIPAA, GDPR, Clinical Trial Data Management
South San Francisco, California, United States · On-site
$24/hr–$40/hr
About Neuralink: We are creating devices that enable a bi-directional interface with the brain. These devices allow us to restore movement to the paralyzed, restore sight to the blind, and revolutionize how humans intera…
Skills: Robotics Operation, Troubleshooting, GLP Documentation, SOP Development, Inventory Management
South San Francisco, California, United States · On-site
$60/hr–$65/hr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Full-Cycle Recruiting, University Recruiting, Event Planning, Stakeholder Management, Candidate Engagement
South San Francisco, California, United States · On-site
$145k–$228k/yr
Job Description We are seeking an innovative and experienced computational protein design scientist to join the Discovery Biologics Protein Engineering department. In this role, you will lead AI- and structure-guided pro…
Skills: Antibodies, Biologics, Computational Biology, Computational Biophysics, Computational Design
South San Francisco, California, United States · On-site
About Westmag Westmag is the American manufacturer of drone motors and robot actuators, backed by Andreessen Horowitz, Founders Fund, Lux Capital, NFDG, Menlo Ventures, and other top investors. Westmag is committed to bu…
Skills: CAD, PCB Layout, Embedded Programming, Data Analysis, Simulation
South San Francisco, California, United States · On-site
$161k–$312k/yr
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more t…
Skills: Self-supervised Representation Learning, Generative Modeling, Deep Learning, Machine Learning, Computational Science
San Francisco, California, United States · Hybrid
$138k–$246k/yr
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headqua…
Skills: System Architecture, People Management, Agile Methodology, Cloud Computing, CI/CD
South San Francisco, California, United States · On-site
$130k–$190k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: PCBA Manufacturing, Design For Manufacturing (DfM), Supplier Quality Management, Root Cause Analysis, Statistical Process Control (SPC)
South San Francisco, California, United States · Hybrid
$158k–$263k/yr
Purpose of Onyx The Onyx Research Data Tech organization is GSK’s Research data ecosystem which has the capability to bring together, analyze, and power the exploration of data at scale. We partner with scientists across…
Skills: Python, GCP, Azure, AWS, Spark
South San Francisco, California, United States · On-site
$145k–$228k/yr
Job Description We are seeking an innovative and experienced computational protein design scientist to join the Discovery Biologics Protein Engineering department. In this role, you will lead AI- and structure-guided pro…
Skills: Antibodies, Biologics, Computational Biology, Computational Biophysics, Computational Design
South San Francisco, California, United States · On-site
$110k–$120k/yr
We advance science so that we all have more time with the people we love. The Department of Human Genetics at Genentech is seeking a highly motivated Postdoctoral Fellow (Computational) to develop and apply novel statist…
Skills: Computational Biology, Bioinformatics, Statistical Genetics, Rare-Variant Association Testing, Protein Structure Analysis
South San Francisco, California, United States · On-site
$129k–$239k/yr
Why Genentech We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while boldly p…
Skills: UX/UI Design, User-Centered Design, Figma, Rapid Prototyping, Wireframing
South San Francisco, California, United States · On-site
$142k–$269k/yr
Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a r…
Skills: Clinical Trial Design, Modeling and Simulation, Artificial Intelligence, Data Science, Statistics
South San Francisco, California, United States · On-site
$145k–$185k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: C, C++, Python, Linux Kernel, Real-time Systems
South San Francisco, California, United States · On-site
$113k–$300k/yr
About Zipline Zipline is the world’s largest and most experienced drone delivery service. We are on a mission to serve all humans equally by ensuring access to food, medicine and essential goods anytime, anywhere. We des…
Skills: Operational Problem Solving, Workflow Optimization, Data Analysis, Cross-functional Collaboration, Systems Thinking
South San Francisco, California, United States • On-site
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
Design, build, and deploy production-ready AI applications and autonomous agentic systems to improve clinical and operational healthcare workflows. Develop RAG systems and scalable AI infrastructure to unlock value from genomic, imaging, and clinical data.
Requires 4+ years of experience building AI or data-driven applications specifically within healthcare or life sciences environments. Must be proficient in Python and SQL with proven experience deploying LLM-based applications to real-world users.
Human Longevity, Inc. (HLI) is a leader in precision health, combining genomics, advanced imaging, biomarker testing, and artificial intelligence to transform the future of proactive healthcare. Our mission is simple: help people live longer, healthier lives through earlier detection, personalized insights, and data-driven healthcare.
We believe AI will fundamentally reshape healthcare over the next decade. From clinician copilots and patient-facing assistants to autonomous workflows and intelligent healthcare operations, AI will become deeply embedded across every aspect of healthcare delivery.
We are looking for an exceptional Applied AI Engineer who can help build that future. This is not a traditional data science role. This is a hands-on engineering role focused on building, deploying, and scaling real-world AI applications that create measurable impact across clinical, operational, and member experiences.
As an Applied AI Engineer, you will build AI-powered products and agentic systems that help clinicians, care teams, operations staff, and members work more effectively.
You will rapidly prototype, deploy, and iterate on AI solutions using the latest advances in Large Language Models, Retrieval-Augmented Generation (RAG), agent frameworks, and healthcare data platforms.
Build AI Products
Design, build, and deploy AI-powered applications from concept to production.
Rapidly prototype new ideas and transform them into production-ready systems.
Partner directly with clinicians, operators, and business stakeholders to identify high-value opportunities.
Deliver solutions that create measurable operational, clinical, or member-facing impact.
Build AI Agents
Design and deploy autonomous and semi-autonomous AI agents.
Implement multi-agent workflows that automate complex healthcare processes.
Evaluate and integrate modern agent frameworks and orchestration platforms.
Build AI assistants that support clinical operations, member engagement, and internal productivity.
Develop LLM Applications
Build applications leveraging state-of-the-art Large Language Models.
Develop Retrieval-Augmented Generation (RAG) systems across structured and unstructured healthcare data.
Optimize prompts, workflows, evaluation systems, and agent behavior.
Implement knowledge retrieval systems that unlock value from clinical, genomic, imaging, and operational data.
Engineer AI Infrastructure
Build scalable data pipelines and AI services.
Create reusable AI components, APIs, and internal platforms.
Improve reliability, observability, performance, and security of AI systems.
Support deployment and monitoring of production AI applications.
Own End-to-End Delivery
Take ownership from idea through production deployment.
Work cross-functionally with engineering, clinical, operations, and leadership teams.
Continuously evaluate and improve AI solutions based on real-world outcomes.
Healthcare Experience (Required)
4+ years of experience building software, AI, machine learning, or data-driven applications within healthcare, life sciences, biotechnology, genomics, diagnostics, digital health, or clinical environments.
Direct experience working with healthcare data, including one or more of:
Clinical records
Laboratory data
Genomics data
Imaging reports
Physician documentation
Patient communications
Healthcare operational workflows
Strong understanding of healthcare terminology, clinical workflows, and the practical challenges of deploying AI solutions in healthcare settings.
AI Engineering Experience
Proven experience building and deploying production AI applications.
Hands-on experience with Large Language Models (LLMs) and modern AI application development.
Experience with Retrieval-Augmented Generation (RAG), agentic AI systems, prompt engineering, and workflow automation.
Strong product mindset with the ability to identify business problems and rapidly build solutions.
Experience deploying systems used by real customers, clinicians, patients, or operational teams.
Technical Skills
Strong proficiency in Python.
Experience with SQL and modern database technologies.
Experience with APIs, integrations, and distributed systems.
Familiarity with cloud platforms and modern software engineering practices.
Strong understanding of software architecture, testing, and deployment.
Experience with genomics, precision medicine, longevity medicine, radiology, pathology, or advanced diagnostics.
Experience with healthcare interoperability standards such as FHIR and HL7.
Experience building clinician-facing AI products.
Experience building patient-facing AI assistants.
Experience with healthcare privacy, security, and compliance requirements.
Startup or high-growth technology company experience.
Experience With One or More of the Following
OpenAI, Anthropic, Gemini, or similar foundation models
LangGraph
LangChain
CrewAI
AutoGen
PydanticAI
Vector databases
Enterprise search systems
Agent orchestration platforms
Workflow automation tools
You will thrive at HLI if you:
Love building and shipping products quickly.
Enjoy solving messy, real-world problems.
Are excited about the future of AI agents.
Can move from concept to production with minimal oversight.
Prefer impact over academic research.
Are energized by startup environments and rapid iteration.
Want to help transform healthcare through technology.
Work at the intersection of AI, genomics, diagnostics, and precision medicine.
Build systems used by clinicians, healthcare teams, and members every day.
Cutting-Edge Technology
Work with the latest AI models, agent frameworks, healthcare datasets, and precision medicine technologies.
Help advance HLI’s mission to extend healthy human lifespan through proactive, personalized healthcare.
Live a healthier, longer life.
Human Longevity, Inc. ™ (HLI) is the genomics-based, health intelligence company creating the world’s largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries from these data to generate personalized health insights. Our goal is to extend healthy human life by revolutionizing human health and transforming the practice of medicine. Our DNA determines so much about each of us, but other factors can also influence our health. HLI is focused on compiling and analyzing more genotypic and phenotypic data because the combination of both enables us —to generate unprecedented insights and accelerate our understanding into what makes us who we are and what we can change for a life better lived.
Offices: 600 Gateway Blvd, South San Francisco, California 94080, US · 4570 Executive Drive, San Diego, CA 92121, US
Based on 161 listings with disclosed salaries, most technology jobs in South San Francisco, CA pay between $130k–$265k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 194 open technology positions in South San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Zipline, Roche, Xaira Therapeutics, Cellares, Eli Lilly and Company, among others. Browse the listings above to see every active employer.
Yes — 24 of the 194 open technology positions offer remote or hybrid work (2 remote, 22 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
