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San Francisco, California, United States · On-site
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San Francisco, California, United States • On-site
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Architect and operate scalable Kubernetes clusters to orchestrate thousands of persistent AI agent workloads. Develop custom resource definitions and operators to manage the lifecycle of scientific research pipelines and compute tasks.
Requires 10+ years of infrastructure experience with deep expertise in Kubernetes internals, CRDs, and cloud platforms like AWS, GCP, or Azure. Proficiency in systems programming and infrastructure-as-code tools is essential for managing high-scale production environments.
Edison Scientific builds and deploys AI scientist agents to accelerate science and the development of new medicines. We are an ambitious team run by scientists and engineers from leading institutions across biology, physics, chemistry, and AI.
As a Principal MTS, you'll play a key role in designing, scaling, and operating the core platform infrastructure that powers autonomous scientific discovery. Your primary focus will be the orchestration for our agents at scale — building and managing clusters that orchestrate thousands of persistent, stateful workloads, developing custom resource definitions (CRDs) and operators, and ensuring the reliability and efficiency of our compute layer at scale.
Our mission is to build an AI scientist, and you'll own the infrastructure foundation it runs on. AI agents performing long-running scientific research demand resilient scheduling, lifecycle management, and resource orchestration far beyond typical cloud-native workloads. This role will influence platform architecture, establish infrastructure best practices, and partner closely with backend engineers, ML engineers, and researchers to deliver a production-grade environment that lets science move faster.
At Edison Scientific, engineering at the senior level is about technical ownership and leverage- understanding how complex systems interact, making sound architectural tradeoffs, and building foundations that allow teams and science to move faster.
This role is on-site at our San Francisco office in the Dogpatch neighborhood. Our office is a converted warehouse with high ceilings, open space, and a team that genuinely believes in what they're building.
This position is part of the Platform team.
Architect, implement, and operate Kubernetes clusters that support thousands of concurrent, persistent resources (agents, jobs, services) with high availability and efficient resource utilization.
Design and develop custom resource definitions (CRDs) and Kubernetes operators to model and manage domain-specific workloads such as AI agent lifecycles, research pipelines, and long-running compute tasks.
Drive the strategy for cluster scaling, node pool management, autoscaling policies, and resource quota frameworks to handle rapid workload growth.
Build and maintain infrastructure-as-code (Terraform, Pulumi, or similar) for reproducible, version-controlled environment management.
Design and implement robust scheduling, placement, and affinity strategies to optimize cost, performance, and fault tolerance for heterogeneous workloads (CPU, GPU, memory-intensive).
Establish and uphold best practices around observability, monitoring, alerting, and incident response for infrastructure systems (Prometheus, Grafana, Datadog, or similar).
Own storage and networking strategy within Kubernetes — including persistent volume management, CSI drivers, service mesh, network policies, and ingress architecture.
Troubleshoot complex, cross-system infrastructure issues and guide others through effective debugging and remediation in distributed environments.
Collaborate closely with backend, ML, and research teams to understand workload requirements and translate them into reliable infrastructure patterns.
Typically, 10+ years of professional infrastructure or platform engineering experience, with deep hands-on Kubernetes expertise in production environments.
Experience designing and implementing custom resource definitions (CRDs) and Kubernetes operators (using frameworks such as Kubebuilder, Operator SDK, or controller-runtime).
Track record of operating and scaling Kubernetes clusters supporting thousands of persistent or long-lived resources (stateful workloads, persistent pods, long-running jobs).
Deep understanding of Kubernetes internals — API server, etcd, scheduler, controller manager, kubelet — and how they behave at scale.
Expertise with cloud infrastructure (AWS EKS, GCP GKE, or Azure AKS) and associated networking, storage, and IAM primitives.
Proficiency in at least one systems or backend language for operator development and infrastructure tooling.
Hands-on experience with infrastructure-as-code tools (Terraform, Pulumi, or Crossplane) and GitOps workflows.
Strong working knowledge of container networking (CNI plugins, service mesh, network policies), storage (CSI, persistent volumes, StatefulSets), and security (RBAC, Pod Security Standards, secrets management).
Ability to operate autonomously, make sound technical judgments, and drive projects from concept through production.
Experience with data-intensive platforms, scientific computing, or ML/AI infrastructure.
Prior experience in startups or small teams with significant architectural ownership and ambiguity.
Experience scaling systems, teams, or platforms through periods of rapid growth.
$200,000 - $350,000 • Offers equity
Competitive salary and equity
Full healthcare coverage; we pay 100% of premiums for you and your dependents
Support for growing families, including a yearly new parent stipend and fertility coverage through Carrot
Mental health support through Rula, our in-network therapist and psychiatrist network with fast availability
12 weeks of paid parental leave for maternity, paternity, and adoption
Pet care support with a yearly employer-funded stipend for your animal companions
Commuter benefits so you can pay for transit and parking with pre-tax dollars
401(k) company matching
$300 health and wellness benefit quarterly
Lunch is on us every day you're in the office, and dinner is on us when you're working late
Regular team offsites and company events
A fast-moving, mission-driven culture where smart people do their best work and actually enjoy doing it
Edison Scientific is an equal opportunity employer. We do not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other protected characteristic under applicable law.
The AI platform for scientific R&D.
Edison Scientific is building the AI platform for scientific research and development. Kosmos, our AI scientist, collaborates with teams across the full R&D lifecycle, leveraging proprietary data and organizational context to help navigate complex scientific decisions and accelerate timelines from discovery to FDA approval. We believe the full gains from AI in science will only be realized when AI systems are integrated across the entire research and development stack, continuously learning from the evolving scientific context inside an organization. With Edison Scientific, scientists and researchers remain at the center of scientific progress, using AI to amplify their expertise and accelerate discovery at unprecedented speed. Edison is a scientist-led company that was spun out of the nonprofit research lab FutureHouse in 2025, backed by $70M from Spark Capital, Triatomic Capital, Susa Ventures, Pillar Ventures, among other investors.
Offices: San Francisco, California 94107, US
Based on 1029 listings with disclosed salaries, most science & research jobs in San Francisco, CA pay between $90k–$295k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 1,437 open science & research positions in San Francisco, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include UCSF Department of Anesthesia and Perioperative Care, OpenAI, Anthropic, Sutter Health, Astranis Space Technologies, among others. Browse the listings above to see every active employer.
Yes — 586 of the 1437 open science & research positions offer remote or hybrid work (129 remote, 457 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
