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Full-time
postgraduate degree
Relocation packages, Two weeklong shutdowns, Parental leave, Employee resource groups, Annual bonus, Flexible work arrangements
Posted 14d ago
~40 hrs/week
Responsibilities
The Principal Research Scientist will lead the design and implementation of complex in vitro assays to evaluate drug potency and mechanism of action. They will also manage a team of scientists and collaborate with cross-functional departments to advance the research portfolio.
Requirements
Candidates must hold a Ph.D. in a relevant biological discipline with at least 8 years of industry experience, or an M.S. with 12+ years of experience. Proven expertise in cell-based assay development and experience with multiple drug modalities are required.
Full job description
At Elanco (NYSE: ELAN) – it all starts with animals!
As a global leader in animal health, we are dedicated to innovation and delivering products and services to prevent and treat disease in farm animals and pets. At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose – all to Go Beyond for Animals, Customers, Society and Our People.
At Elanco, we pride ourselves on fostering a diverse and inclusive work environment. We believe that diversity is the driving force behind innovation, creativity, and overall business success. Here, you’ll be part of a company that values and champions new ways of thinking, work with dynamic individuals, and acquire new skills and experiences that will propel your career to new heights.
Making animals’ lives better makes life better – join our team today!
Your Role:
As the Principal Research Scientist for In Vitro Assay Development, you will be the ‘Architect of the Lab Test’ for Elanco’s research portfolio. You will serve as the scientific hub for a team dedicated to answering a critical question: does a new drug work in the lab before we ever test it in an animal? By designing and implementing the complex experiments that demonstrate a drug’s potency and mechanism of action, you will directly shape the scientific direction of projects and serve as the bridge between our discovery and development teams.
Your Responsibilities:
Serve as the intellectual leader for the design and development of all critical protein and cell-based assays, providing strategic and technical guidance to project teams.
Architect the end-to-end in vitro screening strategy for diverse projects, designing bespoke assays to probe mechanism-of-action (MOA), determine potency, and characterize cellular responses.
Define and manage the strategic balance of assay development and execution between internal teams and external Contract Research Organizations (CROs).
Drive scientific innovation by evaluating and implementing cutting-edge technologies and new methodologies (e.g., AI/ML applications) to advance our screening cascades.
Lead, mentor, and guide a team of 3-5 scientists, fostering their career development and building a culture of scientific rigor, curiosity, and collaboration.
Act as a key scientific liaison, collaborating closely with leaders in medicinal chemistry, protein engineering, immunology, and virology to drive projects forward.
What You Need to Succeed (Minimum Qualifications):
Education & Experience:Ph.D. in Cell Biology, Molecular Biology, Immunology, or a related discipline with 8+ years of relevant industry experience; OR an M.S. with 12+ years of extensive, relevant industry experience.
Technical Expertise:Demonstrated expertise in developing a wide array of cell-based assays (e.g., signaling, reporter, cytotoxicity, proliferation, target engagement).
Modality Experience:Proven experience withsmall moleculedrug discovery, plus expertise in at least one other modality (large molecules/biologics or vaccines).
Scientific Leadership:A track record of identifying critical scientific problems and independently driving the development of solutions that advance portfolio projects, consistent with an R3 level scientist.
What will give you a competitive edge (Preferred Qualifications):
Experience working across all three modalities: small molecules, large molecules, and vaccines.
Experience translating novel technologies or methodologies (e.g., AI/ML, high-throughput screening) from human health or other fields into an animal health research environment.
Direct experience with the transfer of methods and data between internal teams and external collaborators or CROs.
Demonstrated ability to influence cross-functional teams and manage competing priorities through clear communication and strong collaborative skills.
A deep understanding of pharmacology, immunology, and/or virology principles.
Additional Information:
Travel:5-10%
Location:Global Elanco Headquarters - Indianapolis, IN - Hybrid Work Environment
Don't meet every single requirement? Studies have shown underrecognized groups are less likely to apply to jobs unless they meet every single qualification. At Elanco we are dedicated to building a diverse and inclusive work environment. If you think you might be a good fit for a role but don't necessarily meet every requirement, we encourage you to apply. You may be the right candidate for this role or other roles!
Elanco Benefits and Perks:
We offer a comprehensive benefits package focusing on financial, physical, and mental well-being while encouraging our employees to pursue our purpose! Some highlights include:
Multiple relocation packages
Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)
8-week parental leave
9 Employee Resource Groups
Annual bonus offering
Flexible work arrangements
Up to 6% 401K matching
Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
Elanco may use automated tools, including AI, to support parts of our recruitment process, such as reviewing applications against job‑related criteria and/or transferrable skills. These tools help ensure a consistent, structured evaluation, but they do not make hiring decisions. All decisions involve a human reviewer. For more information on how we handle personal data, please see our Elanco Workforce Privacy Notice.
Related keywords
In vitroAssay developmentDrug discoveryCell biologyMolecular biologyImmunologyVirologyProtein engineeringSmall moleculeBiologicsVaccinesAIMLHigh-throughput screeningPharmacologyCRO
Making life better for animals, makes life better.
Industry
Pharmaceutical Manufacturing
Company size
5,001-10,000 employees
Headquarters
Indianapolis, IN
LinkedIn followers
421,635
Total funding
$253M
At Elanco, we are united by a genuine love and care for animals. Our purpose - making life better for animals, makes life better - fuels us to break boundaries and inspires us to push further, transforming animal care, going beyond to improve outcomes for animals, customers, and society to create a better, more sustainable world. We are veterinarians, pet owners, farmer’s kids and animal lovers. Our team doesn’t just work in the animal health industry - we live it.
By putting customers’ needs at the center of everything we do, our comprehensive portfolios of trusted brands and focused pipeline are transforming the future of animal care. From developing the first treatment for one of the deadliest diseases in puppies to removing needles from diabetes care to pioneering new sustainable market spaces for farmers, we're raising the bar and making a difference - for animals, for our customers and their business.
Offices: 450 Elanco Circle, Indianapolis, IN 46221, US
Food SafetyFood ProductionAnimal HealthPetsand Pet HealthHealth CareBiotechnologySupply Chain ManagementPetManufacturing
How many Science & Research jobs are open in Indianapolis, IN right now?
There are currently 874 open science & research positions in Indianapolis, IN listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Science & Research roles in Indianapolis, IN?
Companies currently hiring include Eli Lilly and Company, Indiana University Health, Quest Diagnostics, Franciscan Health, Danaher, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Science & Research jobs in Indianapolis, IN?
Yes — 146 of the 874 open science & research positions offer remote or hybrid work (65 remote, 81 hybrid).
How do I apply for Science & Research jobs in Indianapolis, IN?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.