Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics
Woburn, Massachusetts, United States · On-site
$115k–$115k/yr
Mid level$45M raised
Spear Bio, founded in 2021, is a well-funded and rapidly growing biotech start-up headquartered in Woburn, Massachusetts. Our proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), is a no…
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Senior$29B raised
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Scientist/Senior Scientist, Assay Development - Neuroscience Biomarkers
Woburn, Massachusetts, United States · On-site
$115k–$115k/yr
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Springfield, Massachusetts, United States · On-site
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Veterinary Technician, MGH Center for Comparative Medicine
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Plainville, Massachusetts, United States · On-site
$103k–$155k/yr
Senior+$20B raised
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Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics
Design and develop ultrasensitive protein-detection assays from concept through verification and transfer. Troubleshoot assay performance issues using mechanistic understanding of binding kinetics and molecular interactions to optimize sensitivity and specificity.
Requirements
Requires a Ph.D. in Chemistry, Biophysics, Bioengineering, or a related field with strong fundamentals in molecular interactions. Candidates must have hands-on experience in immunoassay design and the ability to work onsite in Woburn, MA.
Full job description
Spear Bio, founded in 2021, is a well-funded and rapidly growing biotech start-up headquartered in Woburn, Massachusetts. Our proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), is a novel wash-free immunoassay platform, offering unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring by providing scalable, ultrasensitive solutions that deliver unparalleled accuracy in measuring low-abundant biomarkers, enabling clinicians and researchers to improve patient outcomes and advance global health.
Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics
Our Assay Development team builds assays for low-abundance protein biomarkers that are challenging to measure using conventional approaches. We are seeking a creative, hands-on scientist with strong fundamentals in chemistry, biophysics, and molecular interactions who enjoys solving difficult technical problems from first principles.
The Scientist / Senior Scientist will design, optimize, and troubleshoot innovative protein-detection assays that integrate antibody-based recognition, nucleic-acid interactions, conjugation chemistry, reaction kinetics, and quantitative analytical methods.
We are looking for a scientist who genuinely enjoys troubleshooting. The ideal candidate is persistent, analytical, creative, and comfortable working through uncertainty. This person should be motivated by understanding the underlying mechanism and should thrive in a fast-moving startup environment with high scientific standards.
The successful candidate will be comfortable investigating why an assay behaves unexpectedly, developing mechanistic hypotheses, designing discriminating experiments, and systematically improving assay sensitivity, specificity, robustness, and reproducibility.
We welcome applications from exceptional recent Ph.D. graduates and postdoctoral fellows with strong hands-on research ownership, as well as startup and industry scientists who have demonstrated rapid growth in technical scope and responsibility. **This role is based onsite in our lab in Woburn, MA 5 days/week.
Responsibilities:
Design and develop ultrasensitive protein-detection assays from concept through feasibility, optimization, analytical characterization, verification, and transfer.
Develop and optimize antibody and protein-reagent to maximize analytical and clinical performance , including antibody selection, protein structural properties, epitope-pair assessment, conjugation chemistry, reagent purification, and stability evaluation.
Troubleshoot assay-performance issues, including low signal, nonspecific background, limited sensitivity, poor reproducibility, matrix effects, instability, and lot-to-lot variability, using a mechanistic understanding of binding kinetics, affinity, avidity, thermodynamics, steric effects, and molecular interactions.
Design efficient experiments and use structured approaches, including design of experiments where appropriate, to identify root causes and optimize performance.
Collaborate closely with Platform, Product Development, Operations, and Business Development teams to transition assays from feasibility through verification and transfer.
Prepare clear scientific presentations, technical reports, study summaries, abstracts, and publications.
Requirements:
Ph.D. in · Chemistry, Analytical Chemistry, Biophysics, Chemical Engineering, Biochemistry, Bioengineering, Molecular Engineering, or a closely related field.
Strong fundamental understanding of molecular interactions involving nucleic acids, proteins, or both.
Experience with protein–protein and antigen–antibody interactions, including affinity, avidity, kinetics, and thermodynamics.
Demonstrated hands-on experience creating and designing immunoassays, protein-detection methods, molecular-diagnostics assays, or an innovative life-science analytical platform.
Strong experimental-design and troubleshooting skills, with the ability to develop mechanistic hypotheses and test them efficiently.
Demonstrated ability to work independently, analyze complex data, and make sound technical decisions.
· Evidence of meaningful scientific contributions through peer-reviewed publications, patents, conference presentations, or platform-development programs.
· Strong written and verbal communication skills.
· Ability to work onsite five days per week in Woburn, Massachusetts. Candidates must be based in the Greater Boston area or able to relocate before the start date.
Can work 5 days/week on site in Woburn, MA .
We offer competitive compensation, meaningful stock ownership, comprehensive benefits, and a great work environment. This is an opportunity to enter an innovative, high-growth startup at an early stage and play an integral role in the company's growth and success. We are focused on identifying candidates who have demonstrated leadership and excellence throughout their careers and are excited by the prospect of building an industry-leading company.
Spear Bio Inc. provides equal opportunity in employment to all persons. No person shall be denied equal access because of race, creed, color, religion, national origin, sex, sexual orientation, gender identity, age, or physical/mental disability.
Spear Bio does not accept resume submissions from external recruiting agencies. Any unsolicited resumes or candidate information submitted without prior written agreement will be deemed the property of Spear Bio, and no placement fees will be paid.
The first homogeneous immunoassay platform offering unmatched sensitivity with scalable simplicity.
Industry
Biotechnology Research
Company size
11-50 employees
Founded
2021
Headquarters
Boston, MA
LinkedIn followers
6,759
Total funding
$45M
Spear Bio, founded in 2021, is a well-funded and rapidly growing start-up headquartered in Woburn, Massachusetts. Spear Bio’s proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), employs a unique 2-factor authentication mechanism to precisely measure protein biomarkers at attomolar levels from sub-microliter sample volumes, enabling unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring, empowering clinicians and researchers to improve patient outcomes, and advance global health.
For more information, please visit www.spear.bio or email [email protected].
How much do Science & Research jobs in Massachusetts pay?
Based on 4337 listings with disclosed salaries, most science & research jobs in Massachusetts pay between $90k–$240k per year. Individual offers vary with seniority, company size, and specialization.
How many Science & Research jobs are open in Massachusetts right now?
There are currently 7,032 open science & research positions in Massachusetts listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Science & Research roles in Massachusetts?
Companies currently hiring include Mass General Brigham, Sanofi, Takeda, Harvard Division of Medical Sciences, Thermo Fisher Scientific, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Science & Research jobs in Massachusetts?
Yes — 2171 of the 7032 open science & research positions offer remote or hybrid work (470 remote, 1701 hybrid).
How do I apply for Science & Research jobs in Massachusetts?
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
