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$279k–$302k/yr
Full-time
postgraduate degree
Posted 23d ago
~40 hrs/week
Responsibilities
Lead the development and execution of integrated translational medicine and biomarker strategies to advance clinical-stage programs. Integrate biological and pharmacological data to inform development decisions and support regulatory submissions.
Requirements
Requires a PhD, PharmD, or MD in a relevant scientific field with over 12 years of biotechnology or pharmaceutical industry experience. Must have a proven track record in translational medicine and clinical drug development, preferably in immunology or cardiovascular disease.
Full job description
Kiniksa Pharmaceuticals is a commercial‑stage biopharmaceutical company developing and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications. With deep expertise in immunology and inflammation, Kiniksa is advancing a growing portfolio of approved and investigational medicines, anchored by its lead product, ARCALYST®, the first and only FDA‑approved therapy for recurrent pericarditis. Grounded in rigorous science and bold innovation, the company fosters a highly collaborative, patient‑first culture led by accomplished life sciences leaders. At Kiniksa, talented individuals are trusted and empowered to make a real impact—shaping the future of medicine while improving the lives of patients who need it most.
Kiniksa is seeking an accomplished and strategic Senior Director, Clinical Translational Scientist reporting to GVP, Research & Non-Clinical Developmentto play a critical leadership role in advancing clinical-stage development programs from early clinical development through proof-of-concept and registrational studies. The successful candidate will drive translational strategies that connect disease biology, mechanism of action, biomarkers, pharmacology, and clinical outcomes to enable data-driven development decisions.
This individual will serve as a key scientific leader across multidisciplinary teams, integrating insights from Research, Clinical Development, Clinical Pharmacology, Bioanalysis, Biostatistics, Regulatory Affairs, and Medical Affairs to maximize the probability of technical and regulatory success across the portfolio. The role requires deep expertise in translational medicine, biomarker strategy, immunology, and clinical drug development.
This role is based in our Lexington, MA office. Our office-based employees follow an onsite schedule of 5 days in the office (Mon-Fri)
Responsibilities (including, but not limited to):
Lead development and execution of integrated translational medicine strategies across clinical development programs.
Develop and continually refine biomarker and clinical pharmacology plans to support target engagement, proof-of-mechanism, proof-of-biology, dose optimization, and patient selection.
Translate emerging biological, pharmacological, and clinical data into actionable development recommendations.
Identify and prioritize translational milestones to inform key portfolio decisions and stage-gate transitions.
Partner with bioanalytical and laboratory teams to develop, validate, and implement clinical biomarker assays.
Lead interpretation of biomarker, PK/PD, and clinical datasets to generate insights regarding mechanism of action, treatment response, and resistance pathways.
Support implementation of innovative technologies and emerging translational approaches.
Contribute to study design, protocol development, endpoint selection, statistical analysis planning, and clinical study execution.
Build productive relationships with internal stakeholders, external partners, CROs, academic investigators, key opinion leaders, and laboratory vendors.
Contribute translational components to regulatory submissions including INDs, briefing documents, and marketing applications.
Support interactions with health authorities related to biomarkers, companion diagnostics, and translational strategy.
Maintain awareness of emerging scientific advances and competitive developments within immunology, inflammation, cardiovascular disease, and related therapeutic areas.
Foster a collaborative, patient-focused, and scientifically rigorous culture.
Contribute to departmental strategy, capability building, and organizational development.
Standout Skills for Impact:
Expertise in developing and executing translational medicine and biomarker strategies across clinical development programs.
Proven ability to integrate scientific, biomarker, and clinical data to deepen the understanding of patient populations and drug mechanism of action in patients.
Experience leading and influencing cross-functional teams across Research, Clinical Development, Regulatory Affairs, and Medical Affairs.
Demonstrated success supporting programs from early clinical development through proof-of-concept and late-stage studies.
Qualifications and Experience:
PhD, PharmD, MD, or MD/PhD in Immunology, Translational Medicine, Pharmacology, Molecular Biology, Clinical Science, or related discipline.
Advanced clinical development and translational medicine expertise strongly preferred.
12+ years of biotechnology or pharmaceutical industry experience, with significant experience in translational medicine and clinical drug development.
Demonstrated success supporting programs from IND through proof-of-concept and/or late-stage clinical development.
Experience in immunology, inflammation, cardiovascular disease, rare disease, or related therapeutic areas preferred.
Working knowledge of biomarker development, clinical pharmacology, PK/PD relationships, and model-informed drug development.
Experience supporting regulatory interactions and submissions.
Compensation decisions are based on objective criteria including role responsibilities, experience/qualifications, internal equity, geographic location, and external market benchmarks.
Pay Range
$279,450—$302,220 USD
Kiniksa is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, transgender status, age, genetics, national origin, protected veteran status, or disability status, or any other legally protected category. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Kiniksa does not accept unsolicited resumes from staffing agencies or search firms. Any resumes submitted without a signed agreement will be considered property of Kiniksa, and no fees will be paid.
Kiniksa is a biopharmaceutical company dedicated to improving the lives of patients suffering from debilitating diseases by discovering, acquiring, developing, and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications. Kiniksa’s portfolio of assets is based on strong biologic rationale or validated mechanisms and offers the potential for differentiation.
At Kiniksa, patients are at the heart of everything we do. Our Every Second Counts! mindset reflects our commitment to making a difference for people who are navigating the uncertainty and challenges of life-altering diseases. This is why our team is relentless in pursuing treatments that bring us closer to a better future for patients, every second of every day.
We rely on an exceptional team to drive our mission of building a global, generational company. If you're passionate about making a meaningful impact, we’d love to hear from you.
Kiniksa offers competitive benefits and dynamic career opportunities across our organization. We foster a culture of passion, innovation, and rapid execution to help fulfill our mission.
Offices: 100 Hayden Ave, Lexington, Massachusetts 02421, US · 105 Piccadilly, Second Floor, London, England W1J 7NJ, GB · Grafenaustrasse 5, Zug, ZG 6300, CH · 3366 N Torrey Pines Ct, #320, San Diego, California 92037, US
How much do Science & Research jobs in Massachusetts pay?
Based on 4280 listings with disclosed salaries, most science & research jobs in Massachusetts pay between $90k–$237k per year. Individual offers vary with seniority, company size, and specialization.
How many Science & Research jobs are open in Massachusetts right now?
There are currently 6,922 open science & research positions in Massachusetts listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Science & Research roles in Massachusetts?
Companies currently hiring include Mass General Brigham, Harvard Division of Medical Sciences, Takeda, Sanofi, Thermo Fisher Scientific, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Science & Research jobs in Massachusetts?
Yes — 2166 of the 6922 open science & research positions offer remote or hybrid work (476 remote, 1690 hybrid).
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