Research Associate, Microfluidics & Platform Operations
Boston, Massachusetts, United States · On-site
$65k–$107k/yr
Mid level$115M raised
The Role Ampersand is actively seeking a talented Microfluidics Microfabrication Engineer with specialization in droplet microfluidic-based single cell assay development in the field of Antibody Discovery. The role will …
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Boston, Massachusetts, United States · On-site
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Boston, Massachusetts, United States · On-site
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Vertex Inc.
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Boston, Massachusetts, United States · On-site
$104k–$156k/yr
Mid level$345M raised
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Research Associate, Microfluidics & Platform Operations
Design, fabricate, and optimize novel microfluidic devices to support ultrahigh-throughput antibody discovery. This includes performing cleanroom manufacturing, conducting experiments on microfluidic platforms, and collaborating with R&D teams to translate requirements into system specifications.
Requirements
Requires a Bachelor's or Master's degree in Physics, Mechanical Engineering, Biomedical Engineering, or a related field. Candidates must have demonstrable expertise in cleanroom microfabrication, CAD design, and experience running droplet microfluidic experiments.
Full job description
The Role
Ampersand is actively seeking a talented Microfluidics Microfabrication Engineer with specialization in droplet microfluidic-based single cell assay development in the field of Antibody Discovery. The role will focus on the development of a variety of novel microfluidic devices to facilitate the discovery of rare antibodies at Ultrahigh-throughput using our proprietary microfluidic instrumentation. Level and title will be matched to the candidate’s depth of experience.
As a vital member of our team, you will be primarily responsible for the design, fabrication, and optimization of microfluidic devices that will drive our microfluidics-based antibody discovery platform. This role offers an exciting opportunity to work in a dynamic, fast-paced, entrepreneurial environment, where you will have the chance to work independently and collaboratively within a highly integrated team. This role will be primarily based on-site, though occasional visits to an external cleanroom facility will be required to microfabricate device masters.
Key Responsibilities
Support the creation, iteration and establishment of novel microfluidic device designs for antibody discovery applications.
Perform cleanroom-based manufacture of multi-layer device masters via mask alignment and UV photolithography.
Develop and optimize PDMS soft lithography device manufacturing methods to improve device yield
Fabricate microfluidic devices, maintain and document device stock levels, and perform device quality control characterizations, providing detailed reports which inform decision making and continuous improvement.
Conduct experiments by operating microfluidic platforms and analyze data to inform iterative process development.
Troubleshoot device and/or system issues and identify ways to optimize processes.
Analyze, interpret, document, and communicate results to cross-functional teams.
Collaborate with our internal R&D teams to translate project requirements into system specifications.
Maintain meticulous documentation of designs, cleanroom fabrication protocols, device master quality control (QC) characterizations, and experimental results to ensure traceability and facilitate knowledge transfer.
Support assay development workflows through reagent preparation, sample preparation, fluorescence-based readouts, and cell- or bead-based assay setup for antibody discovery applications.
Maintain an understanding of the latest research and advancements in the field, fostering innovation within our team.
Required Professional Experience & Qualifications
Bachelor or Master of Physics, Mechanical Engineering, Biomedical Engineering, or a related field.
Experience in 2D and 3D CAD design for custom device designs, e.g., AutoCAD, SolidWorks, and/or SolidEdge.
Demonstrable expertise in cleanroom-based microfabrication of microfluidics and/or MEMS devices, including mask alignment, UV photolithography, and PDMS soft lithography.
Experience with fabricating and quality checking PDMS devices, plus maintaining device and consumable inventories.
Experience with running and troubleshooting microfluidic experiments, particularly in droplet microfluidics.
Exposure to surface modification techniques to tailor microchannel properties for biological applications.
Proficiency in data processing and analysis to enable interpretation of results.
Excellent written and verbal communication skills to effectively present results and scientific data to team leaders, cross-functional teams, academic collaborators, or partners.
Preferred Professional Experience & Qualifications
Exposure to any combination of mask alignment, UV photolithography, imprint lithography, injection molding, metal deposition, wafer dicing, laser ablation, and/or thermal bonding in a cleanroom setting is advantageous.
Experience with supporting biological assay workflows, including reagent preparation, sample preparation, fluorescence-based readouts, cell-based screening workflows, or droplet-based antibody discovery assays, is advantageous.
Exposure to library screening or cell line development workflows, including vector cloning, transfection, selection, and expansion.
Ampersand Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Ampersand Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Ampersand and/or Flagship Pioneering or its employees is strictly prohibited unless contacted directly by Ampersand or Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Ampersand and FSP, and Ampersand/FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $65,000 - $107,300. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Ampersand currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Ampersand’s good faith estimate as of the date of publication and may be modified in the future.
Ampersand Biomedicines enables a new way of designing programmable medicines that work precisely where needed in the body and nowhere else. The company’s state-of-the-art computationally powered Address, Navigate, Design (AND)™ Platform continually learns the rules for identifying optimal localizer targets and refines its ability to design across the complex space of localizers and actuators. The result is increasingly sophisticated AND-Body™ therapeutics that are engineered across the physical constraints of molecules and the biological characteristics of the targets to effectively target the site of disease without affecting healthy tissue or cells. Ampersand Biomedicines was founded in 2020 at Flagship Labs, a unit of Flagship Pioneering.
How many Manufacturing jobs are open in Boston, MA right now?
There are currently 699 open manufacturing positions in Boston, MA listed on Clera. New openings are added daily as companies post roles.
Which companies are hiring for Manufacturing roles in Boston, MA?
Companies currently hiring include WHOOP, Vertex Pharmaceuticals, Vertex Inc., mouhamedzz, Thermo Fisher Scientific, among others. Browse the listings above to see every active employer.
Are there remote or hybrid Manufacturing jobs in Boston, MA?
Yes — 218 of the 699 open manufacturing positions offer remote or hybrid work (66 remote, 152 hybrid).
How do I apply for Manufacturing jobs in Boston, MA?
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