San Diego, California, United States · On-site
$114k–$156k/yr
JOB SUMMARY We are seeking an experienced and highly motivated Research Scientist, Purification & Analytical Sciences to develop and advance small-molecule purification and high-throughput analytical capabilities within …
Skills: SFC purification, LC purification, Analytical QC, Method development, Chromatography
Chula Vista, California, United States · On-site
Protech Automotive Solutions and its affiliated brands is looking for highly talented, dedicated and quality-focused teammates to provide top tier service to our customers. JOB SUMMARY Build Your Skills. Work With Techno…
Skills: Automotive repair, Electrical diagnostics, Fleet maintenance, GPS installation, Telematics
San Diego, California, United States · Remote OK
$23/hr–$52/hr
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less in…
Skills: Pharmacology, Pharmacometrics, Pharmacokinetics, Pharmacodynamics, Translational modeling
San Diego, California, United States · On-site
$88k–$164k/yr
Job Title: Senior Specialist, PCB Layout Designer Job Code: 42618 Job Location: San Diego, CA Job Schedule: 9/80 Employees work 9 out of every 14 days- totaling 80 hours working- and have every other Friday off Job Descr…
Skills: PCB layout, Mentor PADS, Expedition, HDI PCB design, Valor NPI
San Diego, California, United States · Hybrid
$114k–$140k/yr
Scope of Job PowerFlex, an EDF power solutions company, is a leading national provider of intelligent onsite energy solutions that support cost-effective and low-carbon electrification and transportation. We deliver inte…
Skills: Project management, Construction management, Solar PV, Battery energy storage, EV charging
San Diego, California, United States · Hybrid
$106k–$169k/yr
We are the people who give possibilities purpose BD is one of the largest global medical technology companies in the world. Advancing the world of health™ is our Purpose, and it’s no small feat. It takes the imagination …
Skills: Systems engineering, Product development lifecycle, Requirements management, Verification and validation, Risk management
Northrop Grumman Mission Systems, Inc.San Diego, California, United States · On-site
$43k–$73k/yr
RELOCATION ASSISTANCE: No relocation assistance available CLEARANCE REQUIRED FOR START: No CLEARANCE TYPE: Secret TRAVEL: Yes, 10% of the TimeDescription At Northrop Grumman, our employees have incredible opportunities t…
Skills: Electronics manufacturing, Soldering, J-Standard solder certification, Pick and place machines, RF circuit cards
San Diego, California, United States · On-site
$63k–$120k/yr
Date Posted: 2026-09-09 Country: United States of America Location: US-CA-SAN DIEGO-SD1 ~ 8650 Balboa Ave ~ SAN ANTONIO BLDG Position Role Type: Onsite U.S. Citizen, U.S. Person, or Immigration Status Requirements: The a…
Skills: Systems engineering, Hardware integration, Software integration, Test planning, Troubleshooting
San Diego, California, United States · On-site
About the Role We are looking for Autonomous Vehicle Safety Operators (Safety Drivers) to support the testing, validation, commercial deployment, and scaling of autonomous vehicle (AV) and robotaxi fleets across North Am…
Skills: Defensive driving, Situational awareness, Vehicle inspection, Data reporting, Safety compliance
San Diego, California, United States · On-site
$76k–$144k/yr
Date Posted: 2026-09-09 Country: United States of America Location: US-CA-SAN DIEGO-SD1 ~ 8650 Balboa Ave ~ SAN ANTONIO BLDG Position Role Type: Onsite U.S. Citizen, U.S. Person, or Immigration Status Requirements: The a…
Skills: Systems engineering, Hardware integration, Software integration, Test planning, Troubleshooting
Northrop Grumman Mission Systems, Inc.San Diego, California, United States · On-site
$100k–$150k/yr
RELOCATION ASSISTANCE: No relocation assistance available CLEARANCE REQUIRED FOR START: No CLEARANCE TYPE: Secret TRAVEL: Yes, 10% of the TimeDescription At Northrop Grumman, our employees have incredible opportunities t…
Skills: Materials Planning, Production Scheduling, SAP, MRP, Supply Chain Management
Northrop Grumman Mission Systems, Inc.El Segundo, California, United States · On-site
$84k–$151k/yr
RELOCATION ASSISTANCE: Relocation assistance may be available CLEARANCE REQUIRED FOR START: Yes CLEARANCE TYPE: Secret TRAVEL: Yes, 10% of the TimeDescription At Northrop Grumman, our employees have incredible opportunit…
Skills: Cybersecurity, Systems engineering, System integration, Technical planning, Verification and validation
Northrop Grumman Mission Systems, Inc.San Diego, California, United States · On-site
$101k–$188k/yr
RELOCATION ASSISTANCE: No relocation assistance available CLEARANCE REQUIRED FOR START: Yes CLEARANCE TYPE: Secret TRAVEL: Yes, 10% of the TimeDescription At Northrop Grumman, our employees have incredible opportunities …
Skills: Systems engineering, Cybersecurity, RMF, NIST, DoD STIGs
San Diego, California, United States · Hybrid
$130k–$207k/yr
We are the people who give possibilities purpose BD is one of the largest global medical technology companies in the world. Advancing the world of health™ is our Purpose, and it’s no small feat. It takes the imagination …
Skills: Systems engineering, Product development, Technical leadership, Requirements management, System architecture
Northrop Grumman Mission Systems, Inc.San Diego, California, United States · On-site
$92k–$138k/yr
RELOCATION ASSISTANCE: Relocation assistance may be available CLEARANCE REQUIRED FOR START: Yes CLEARANCE TYPE: Secret TRAVEL: Yes, 10% of the TimeDescription At Northrop Grumman, our employees have incredible opportunit…
Skills: Systems engineering, Requirements development, Verification and validation, Interface control, Python
San Diego, California, United States · Hybrid
$95k–$124k/yr
Department: 107100 Quality Location: San Diego, USA- Remote Be a part of a global team that is inspired to make a difference in the lives of people living with rare disease. At Travere Therapeutics, we recognize that our…
Skills: Quality Assurance, GMP, Validation, Qualification, Technical writing
Anaheim, California, United States · Remote OK
$120k–$180k/yr
We anticipate the application window for this opening will close on - 19 Sep 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore heal…
Skills: People management, Clinical support, Robotic assisted surgery, Neurosurgery, Coaching
San Diego, California, United States · On-site
$42k–$88k/yr
Date Posted: 2026-09-09 Country: United States of America Location: US-CA-SAN DIEGO-SD1 ~ 8650 Balboa Ave ~ SAN ANTONIO BLDG Position Role Type: Onsite U.S. Citizen, U.S. Person, or Immigration Status Requirements: The a…
Skills: Systems engineering, Hardware integration, Software integration, Test planning, Debugging
AbbottSan Diego, California, United States · On-site
$90k–$180k/yr
Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnost…
Skills: Software engineering, Object-oriented programming, C++, Java, JavaScript
San Diego, California, United States · On-site
$96k–$170k/yr
Shield AI is a venture-backed defense-tech company with the mission of protecting service members and civilians with intelligent systems. Its products include Hivemind autonomy software, V-BAT and X-BAT aircraft, and Aec…
Skills: Battery testing, Avionics, Data acquisition, Thermal chambers, Instrumentation
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
Develop and execute small-molecule purification strategies using preparative SFC and LC while supporting high-throughput compound QC workflows. Collaborate with medicinal chemistry and HTE teams to deliver high-quality compounds and analytical data for drug discovery.
Requires a Ph.D. in Chemistry or related field with up to 5 years of experience, or a Master's/Bachelor's degree with significant relevant experience. Candidates must possess strong hands-on expertise in chromatographic purification, method development, and instrument troubleshooting.
We are seeking an experienced and highly motivated Research Scientist, Purification & Analytical Sciences to develop and advance small-molecule purification and high-throughput analytical capabilities within our drug discovery team. This scientist will provide scientific and technical expertise in preparative SFC and LC purification, as well as high-throughput compound QC, supporting medicinal chemistry and high-throughput experimentation (HTE) platform.
A key focus of this role will be SFC-based purification, including method development, optimization, and application to diverse and challenging chemical matter. The ideal candidate will combine strong fundamentals in chromatographic separation science with hands-on expertise in analytical QC, instrument troubleshooting, automation, and high-throughput workflows.
This scientist will work closely with HTE, medicinal chemistry and other discovery teams to rapidly deliver purified, well-characterized compounds and high-quality analytical data, supporting an AI-driven design–make–test–learn drug discovery cycle. This position will be based out of our San Diego Headquarters.
Develop and execute small-molecule purification strategies using preparative SFC and LC, with particular emphasis on SFC method development and optimization.
Independently solve challenging separations through optimization of stationary/mobile phases, selectivity, gradients, sample loading, scale-up, and fraction collection.
Develop and support high-throughput compound QC workflows using LC/MS and related analytical techniques to assess compound identity, purity, and sample quality.
Collaborate with medicinal chemistry and HTE teams to establish fit-for-purpose purification and QC strategies and rapidly deliver high-quality compounds.
Serve as a technical resource for SFC/LC purification, analytical QC, and instrument troubleshooting, including root-cause analysis of chromatography, fluidics, hardware, and software issues.
Provide hands-on support for SFC, LC, and LC/MS platforms, including maintenance, system optimization, and vendor coordination.
Develop and improve automated and high-throughput purification and QC workflows, integrating sample handling, purification, fraction processing, analytical characterization, and data management.
Evaluate and implement new chromatography, analytical, automation, and informatics technologies to expand throughput, capacity, and operational efficiency.
Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 0-5 years of relevant experience; or a MS with 7+ years / BS with 9+ years of relevant experience.
Strong hands-on expertise in small-molecule chromatographic purification and method development, preferably in a pharmaceutical, biotechnology, CRO, or drug discovery environment.
Demonstrated expertise in preparative SFC, including method development, optimization, and troubleshooting; preparative LC experience is strongly preferred.
Strong understanding of chromatographic separation science and demonstrated ability to independently solve complex purification problems.
Strong instrument troubleshooting skills, including experience diagnosing chromatography, fluidics, hardware, software, and workflow issues.
Strong understanding of medicinal chemistry and small-molecule drug discovery, with the ability to translate project needs into effective purification and analytical strategies.
Excellent scientific problem-solving, communication, and collaboration skills.
Experience with high-throughput LC/MS analysis and compound QC, including purity and identity assessment, is strongly preferred.
Experience with automation, high-throughput workflows, and informatics/data-management systems is highly desirable.
Experience with Agilent, Shimadzu, or comparable analytical and purification platforms is a plus.
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
Better technology for better medicines
Iambic is a clinical-stage life sciences & technology company developing novel medicines using its AI-driven platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with industry-leading speed and across multiple target classes and mechanisms of action. Iambic is advancing a disease-agnostic pipeline of potential best-in-class and first-in-class medicines to address urgent unmet patient need. Learn more at iambic.ai
Offices: San Diego, California 92121, US
Based on 3349 listings with disclosed salaries, most engineering jobs in San Diego, CA pay between $76k–$207k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 3,949 open engineering positions in San Diego, CA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Qualcomm, Northrop Grumman, Northrop Grumman Mission Systems, Inc., Apple, Booz Allen Hamilton, among others. Browse the listings above to see every active employer.
Yes — 731 of the 3949 open engineering positions offer remote or hybrid work (129 remote, 602 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
