Cambridge, Massachusetts, United States · Hybrid
$118k–$178k/yr
Are you ready to dive into the world of transformative therapies and make a significant impact? At EsoBiotec, now part of AstraZeneca, we are setting new benchmarks for biotechnological research. Our collaboration combin…
Skills: In vivo pharmacology, Oncology models, Flow cytometry, Viral vectors, Molecular analysis
Cambridge, Massachusetts, United States · Hybrid
$150k–$200k/yr
Here at Humanoid, we believe in a future where robots amplify human potential. That’s why we’ve set out on a mission to build the world’s most capable, commercially-scalable, and safe humanoid robots. We’re bringing that…
Skills: Bazel, Git, CI/CD, GitHub Actions, Python
Cambridge, Massachusetts, United States · On-site
Property Description Join the dynamic team at Hyatt Regency Boston Cambridge, located in the vibrant and innovative city of Cambridge, Massachusetts! As a prestigious hotel in the heart of Kendall Square, we are seeking …
Skills: Refrigeration, Mechanical systems maintenance, Electrical systems maintenance, Preventive maintenance, HVAC
Cambridge, Massachusetts, United States · Hybrid
$20/hr–$45/hr
Overview: Draper is an independent, nonprofit research and development company headquartered in Cambridge, MA. The 2,000+ employees of Draper tackle important national challenges with a promise of delivering successful a…
Skills: Integrated circuit design, ASIC design, MATLAB, Simulink, System Verilog
Cambridge, Massachusetts, United States · On-site
$126k–$182k/yr
Company Summary: Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneerin…
Skills: Immunology, T cell biology, CAR-T therapy, Flow cytometry, In vivo studies
Cambridge, Massachusetts, United States · On-site
The QMS and Reporting Support Contractor position within AIQ will serve as an enabler of multiple QMS initiatives, as well as support reporting and data analysis deliverables. This individual will report into the QMS and…
Skills: Quality Management Systems, Data Analysis, Project Management, Technical Writing, GxP Compliance
Cambridge, Massachusetts, United States · Hybrid
Company Description By working at Harvard University, you join a vibrant community that advances Harvard's world-changing mission in meaningful ways, inspires innovation and collaboration, and builds skills and expertise…
Skills: Oracle APEX, PL/SQL, SQL, HTML, CSS
San Francisco, California, United States · On-site
$116k–$170k/yr
Your Impact at LILA We are growing our Applied AI org and seeking Machine Learning Engineers with expertise in model training, evaluation, and production-oriented ML systems. You’ll work on improving Lila’s AI models for…
Skills: Machine learning, Python, PyTorch, JAX, TensorFlow
Cambridge, Massachusetts, United States · On-site
$76k–$101k/yr
Your Impact at LILA Lila Sciences’ Research Operations team executes the automated laboratory workflows that power our scientific platform. We are seeking a motivated and detail-oriented Engineer I to join our high-throu…
Skills: Laboratory automation, Liquid handling, Molecular biology, Reagent preparation, Aseptic technique
Cambridge, Massachusetts, United States · On-site
$170k–$220k/yr
About Manifold Manifold is the AI platform for life sciences, accelerating life-changing medicines to patients. Our products speed up workflows in areas from target identification and clinical development to market acces…
Skills: Python, Terraform, AWS, Infrastructure-as-code, Distributed systems
Cambridge, Massachusetts, United States · On-site
$126k–$182k/yr
What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Flagship Labs 129 (FL129) is…
Skills: Protein engineering, Deep mutational scanning, Molecular cloning, Yeast surface display, Phage display
Cambridge, Massachusetts, United States · On-site
$143k–$215k/yr
COMPANY DESCRIPTION Founded through Flagship Pioneering’s venture creation engine, Terrana Biosciences is a cutting-edge agricultural biotechnology company developing innovative RNA-based products to address global agric…
Skills: Molecular Cloning, DNA Assembly, Vector Engineering, Construct Design, High-Throughput Workflows
Cambridge, Massachusetts, United States · On-site
$108k–$176k/yr
About Tilde (FL110) Tilde Bio, Inc. (FL110) is building a next-generation biological sensing platform at the intersection of synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processi…
Skills: PCB design, Mixed-signal design, High-speed PCB design, Signal integrity, Power integrity
Cambridge, Massachusetts, United States · On-site
$108k–$176k/yr
About Tilde (FL110) Tilde Bio, Inc. (FL110) is building a next-generation biological sensing platform at the intersection of synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processi…
Skills: MEMS fabrication, Cleanroom process development, Photolithography, Thin-film deposition, Etching
Cambridge, Massachusetts, United States · On-site
$111k–$123k/yr
Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing …
Skills: Quality assurance, Equipment qualification, Software assurance, CSV, Calibration
Cambridge, Massachusetts, United States · On-site
$168k–$269k/yr
Cambridge, US | full time | Job ID: 11672 The ideal candidate will work in a highly collaborative and cross-functional team to develop antibody drug conjugates (ADCs). The position requires close collaborations with vari…
Skills: Organic chemistry, Protein degraders, Molecular glues, Antibody drug conjugates, Drug discovery
Cambridge, Massachusetts, United States · On-site
$82k–$220k/yr
Overview: Draper is an independent, nonprofit research and development company headquartered in Cambridge, MA. The 2,000+ employees of Draper tackle important national challenges with a promise of delivering successful a…
Skills: Thermal Desktop, Finite Element Analysis, Analytical Modeling, Root Cause Analysis, Hardware Validation
Cambridge, Massachusetts, United States · Hybrid
$157k–$249k/yr
Job TitleR&D Technical Lead — Advanced Software Development, ICE Imaging (Cambridge) Job Description R&D Technical Lead — Advanced Software Development, ICE Imaging (Cambridge) The R&D Technical Lead will provide technic…
Skills: Ultrasound imaging, Image processing, Medical image analysis, Computer vision, Machine learning
Cambridge, Massachusetts, United States · On-site
$39k–$111k/yr
Job Description The Future Talent Program features co-ops that last up to 6 months and will include one or more projects. These opportunities in our Research & Development Division can provide you with great development …
Skills: Organic synthesis, Chemical diversification, Proteomics, Cell pharmacology, Drug discovery
Cambridge, Massachusetts, United States · On-site
$95k–$245k/yr
Overview: Draper is an independent, nonprofit research and development company headquartered in Cambridge, MA. The 2,000+ employees of Draper tackle important national challenges with a promise of delivering successful a…
Skills: Integration And Test Engineering, Systems Engineering, MEMS IMU Testing, Technical Leadership, Test Planning
Sign up with Clera and we'll reach out the moment a role actually fits you — no more spraying applications into the void.
The Senior Scientist will design, lead, and interpret preclinical in vivo pharmacology studies to evaluate novel viral vectors for oncology. Responsibilities include performing mouse procedures, managing flow cytometry assays, and analyzing complex molecular data to guide project objectives.
Candidates must possess a BA/BS with 5 years of experience, an MA/MS with 3 years, or a PhD in a relevant scientific discipline. Proven hands-on expertise in oncology mouse models, flow cytometry, and nucleic acid analysis is required.
Are you ready to dive into the world of transformative therapies and make a significant impact? At EsoBiotec, now part of AstraZeneca, we are setting new benchmarks for biotechnological research. Our collaboration combines AstraZeneca’s global influence and scientific innovation with EsoBiotec’s unique culture of creativity and breakthroughs in cell-based therapies and immunology. Here, your scientific passion will drive real-world impact as you contribute to life-changing treatments. We are seeking an experienced Senior Scientist, In Vivo Pharmacology to join a multidisciplinary In Vivo Cell Therapy Discovery team developing innovative viral vectors for oncology.
The successful candidate will design, lead, and interpret preclinical studies evaluating the efficacy, biodistribution, pharmacodynamics, and tolerability of novel viral vectors. This role requires strong hands-on expertise in oncology models, animal procedures, flow cytometry, molecular analysis, and the delivery of high-quality studies in a fast-paced, collaborative research environment.
Key responsibilities
Independently design, plan, and lead in vivo pharmacology studies aligned with project objectives.
Establish, optimize, and evaluate oncology models, including xenograft, syngeneic, and humanized mouse models.
Perform and oversee mouse procedures, including handling, intravenous dosing, monitoring, tissue collection, and necropsy activities, in accordance with approved protocols.
Assess vector biodistribution, transduction, transgene expression, pharmacodynamic activity, anti-tumor efficacy, immune responses, and tolerability.
Design and execute flow cytometry assays, including sample preparation, panel development, controls, data quality assessment, and interpretation.
Perform or oversee nucleic acid extraction and analysis using techniques such as qPCR or digital PCR to measure viral integration and biodistribution.
Analyze and integrate complex in vivo, cellular, and molecular data, identifying key conclusions to recommend next steps.
Maintain accurate and complete study documentation, including protocols, experimental records, sample inventories, data analyses, and study reports.
Communicate study plans, results, and recommendations clearly to project teams and senior stakeholders.
Contribute to a collaborative, high-performing team, and support the development of robust and reproducible experimental workflows.
Essential experience and qualifications
BA/BS with at least 5 years of relevant experience or MA/MS with 3 years' experience or PhD in pharmacology, oncology, immunology, biology, biomedical sciences, or a related discipline.
Demonstrated hands-on experience with oncology and humanized mouse models.
Practical experience handling mice and performing procedures such as intravenous administration, tumor monitoring, tissue collection, and necropsy.
Proven ability to independently lead and deliver well-designed, high-quality in vivo studies.
Experience with flow cytometry and nucleic acid extraction and analysis from primary in vivo samples.
Strong data interpretation, problem-solving, and scientific communication skills.
A strong commitment to data integrity, quality documentation, reproducibility, and animal welfare.
Ability to work effectively in a fast-paced, matrixed environment and manage multiple priorities.
Desirable experience
Experience in pharmaceutical or biotechnology research, preferably within oncology, gene therapy, viral vectors, or translational pharmacology.
Experience with viral vector platforms, vector biodistribution, transduction, or immunogenicity assessment.
Knowledge of tumor immunology, immune-cell profiling, or the tumor microenvironment.
Experience with translational biomarkers, immunohistochemistry, histopathology, or related bioanalytical techniques.
Experience managing CROs and coordinating activities across internal and external teams.
Experience mentoring colleagues or leading cross-functional scientific workstreams.
When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world.
The annual base pay for this position ranges from $118K to $178K. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
We're transforming the future of healthcare by unlocking the power of what science can do for people, society and the planet. For more information, visit www.astrazeneca.com. Community Guidelines: bit.ly/2MgAcio
Offices: 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, Cambridgeshire CB2 0AA, GB · Astraallen, Sodertalje, Stockholm County 152 57, SE
Based on 627 listings with disclosed salaries, most engineering jobs in Cambridge, MA pay between $82k–$240k per year. Individual offers vary with seniority, company size, and specialization.
There are currently 786 open engineering positions in Cambridge, MA listed on Clera. New openings are added daily as companies post roles.
Companies currently hiring include Draper, Lila Sciences, Akamai Technologies, Flagship Pioneering, Harvard Division of Medical Sciences, among others. Browse the listings above to see every active employer.
Yes — 236 of the 786 open engineering positions offer remote or hybrid work (58 remote, 178 hybrid).
Each listing links directly to the employer's application page. Apply early — fresh listings get the most recruiter attention in the first two weeks.
