Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · Hybrid
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · Hybrid
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · Hybrid
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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Pittsburgh, Pennsylvania, United States · On-site
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The postdoctoral associate will conduct research in cellular in situ structural biology, focusing on the organization and function of macromolecular assemblies. Key tasks include investigating ciliary and flagellar biogenesis using Trypanosoma brucei and other eukaryotic organisms.
A PhD in a related field is required. Preferred qualifications include expertise in cryo-EM, cryo-ET, computational image analysis, or cell biology.
The Sun Lab in the Department of Structural Biology at the University of Pittsburgh School of Medicine (https://sunlab.structbio.pitt.edu/) is seeking a highly motivated postdoctoral associate to join a collaborative research program in cellular in situ structural biology. This position will be recruited in close collaboration with Dr. Rui Zhang’s laboratory at Washington University in St. Louis (https://zhangrui.wustl.edu/), providing an exciting opportunity to integrate advanced cellular imaging, high-resolution structural biology, and computational image analysis.
Our research program uses cryo-electron tomography, cryo-focused ion beam milling, single-particle cryo-EM, fluorescence microscopy, molecular and cellular biology and computational structural analysis to investigate the organization and function of macromolecular assemblies in their native cellular environment. Current projects focus on understanding the molecular mechanisms that regulate ciliary and flagellar biogenesis, protein trafficking, and organelle organization using the single-celled eukaryotic parasite Trypanosoma brucei as a model system, with plans to expand the studies to other eukaryotic ciliated organisms.
Cilia and flagella are essential organelles involved in cell signaling, motility, development, and host–pathogen interactions. Defects in ciliary assembly and trafficking are associated with diverse human diseases, including ciliopathies, retinal degeneration, developmental disorders, and infertility. By defining how conserved molecular machines function within cells, our work aims to reveal fundamental principles of organelle biogenesis and provide insight into disease-relevant cellular mechanisms.
The successful candidate will benefit from a collaborative environment combining expertise from the Sun lab and the Zhang lab. The specific projects can be tailored toward cellular cryo-ET, single particle cryo-EM, or computational analysis, depending on the candidate’s expertise and long-term career goals.
Qualifications
PhD in related field
Preferred qualifications include experience in one or more of the following areas:
Prior experience with cryo-ET or cryo-EM image processing is advantageous but not required. Candidates with strong backgrounds in cell biology, structural biology, microscopy, biophysics, computational analysis, parasitology, or related fields who are interested in developing expertise in in situ structural biology are encouraged to apply.
Research Environment
The University of Pittsburgh provides an outstanding environment for structural and cell biology, with access to advanced cryo-EM/cryo-ET instrumentation, cryo-FIB milling (https://www.structbio.pitt.edu/facilities/cryo-electron-microscopy-cryo-em), light microscopy (https://cbi-pitt.webflow.io/), and a highly collaborative biomedical research community. The position will provide strong training in experimental design, advanced imaging, image processing, quantitative analysis, manuscript preparation, grant writing, and career development.
This collaborative recruitment will provide the successful candidate with opportunities to interact closely with both the Sun Lab and Dr. Rui Zhang’s laboratory, combining complementary expertise in cellular cryo-ET, high-resolution cryo-EM, computational image analysis, and integrative structural biology.
The Sun Lab is committed to rigorous science, mentorship, collaboration, and fostering an inclusive and supportive research environment.
Candidates from diverse backgrounds are strongly encouraged to apply.
Life Changing Medicine.
UPMC is a world-renowned, nonprofit health care provider and insurer committed to delivering exceptional, people-centered care and community services. Headquartered in Pittsburgh and affiliated with the University of Pittsburgh Schools of the Health Sciences, UPMC is shaping the future of health through clinical and technological innovation, research, and education. Dedicated to advancing the well-being of our diverse communities, we provide nearly $2 billion annually in community benefits, more than any other health system in Pennsylvania. Our 100,000 employees — including more than 5,000 physicians — care for patients across more than 40 hospitals and 800 outpatient sites in Pennsylvania, New York, and Maryland, as well as overseas. UPMC Insurance Services covers more than 4 million members, providing the highest-quality care at the most affordable price. To learn more, visit UPMC.com.
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