HPLC Oligonucleotide Method Development & Validation
Lancaster, Pennsylvania, United States · On-site
Mid level
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Lancaster, Pennsylvania, United States · Remote OK
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Full-time
bachelor degree, postgraduate degree
Medical coverage, Dental, Vision options, Life insurance, Disability insurance, 401(k) with company match
Posted 1d ago
~40 hrs/week
Responsibilities
The scientist is responsible for developing, validating, and executing analytical methods for oligonucleotide testing using HPLC and mass spectrometry. They will also provide technical leadership, mentor junior staff, and ensure compliance with GxP standards.
Requirements
Candidates must have a BS, MS, or PhD in Analytical Chemistry with relevant industry experience in a GMP-regulated environment. Strong theoretical and practical knowledge of chromatography and mass spectrometry is required, along with authorization to work in the U.S. indefinitely.
Full job description
Company Description
Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins laboratories work with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.
The Eurofins network of companies is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organization services. It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organizations. It also has a rapidly developing presence in highly specialized and molecular clinical diagnostic testing and in-vitro diagnostic products.
In over 30 years, Eurofins has grown from one laboratory in Nantes, France to 58,000 staff across a decentralized and entrepreneurial network of 900 laboratories in over 54 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.
In 2024, Eurofins generated total revenues of EUR € 6,515 billion, and has been among the best performing stocks in Europe over the past 20 years.
Job Description
Applicants MUST have authorization to work in the U.S. indefinitely without restriction or sponsorship.
Job Summary:
The Oligonucleotide Scientist is responsible for developing, optimizing, validating, and executing analytical methods to support oligonucleotide API, drug substance, and drug product testing. The role supports pharmaceutical clients throughout various stages of the drug pipeline but does not support or include synthesis/manufacturing of oligonucleotides. The role focuses primarily on HPLC/UHPLC and mass spectrometry (e.g., LC‑MS, LC‑MS/MS) for identity, purity/impurity profiling, quantitation, and stability-indicating assessments. The scientist will author methods, protocols and reports, ensure data integrity and compliance within GxP environments, and provide technical leadership for routine testing and investigations and mentoring of junior staff. Additional tasks/skills will include:
Performing a large variety of analytical tasks for the validation of analytical methods used in the testing of drug products and raw materials by means of various procedures including HPLC, GC, UV/Vis, and dissolution.
Reading, understanding, and interpreting diverse analytical procedures.
Conducting analytical investigations.
Troubleshoot instrumentation and communicate with vendors when required.
Train and mentor junior staff in laboratory procedures.
Manage and discuss projects with clients.
Applies GMP in all areas of responsibility, as appropriate.
Qualifications
The Ideal Candidate would possess:
Excellent communication (oral and written) and attention to detail.
Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude
Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies
Minimum Qualifications:
At least a BS or MS degree in Analytical Chemistry or related scientific discipline
BS and 4+ years, MS and 2+ years, or PhD and 1+ year of relevant industry experience
Experience performing analytical testing with oligonucleotides in a GMP-regulated environment
Technical Expertise: Strong theoretical and practical knowledge of chromatography (HPLC, UHPLC, IEX, SEC) and mass spectrometry, including method development, validation, and routine testing
Regulatory Knowledge: Familiarity with ICH guidelines and GxP regulatory standards
Background should be primarily in analytical testing or analytical method development; candidates with primarily synthesis or process chemistry experience without analytical/QC responsibilities will not be considered
Authorization to work in the U.S. indefinitely without restriction or sponsorship
Additional Information
Working schedule will be Full-Time, First Shift, Mon-Fri, 8am-4pm. Candidates currently living within a commutable distance of Lancaster, PA are encouraged to apply. 25% travel may be required. This position is NOT remote.
What we Offer:
Excellent full time benefits including comprehensive medical coverage, dental, and vision options
Life and disability insurance
401(k) with company match
Paid vacation and holidays
Eurofins USA BioPharma Services is a Disabled and Veteran Equal Employment Opportunity employer.
It’s so much more than a specimen. It's a life.
With over 30 years of specialized expertise in infectious disease, immunology, transplant, and allergy testing for immunocompromised and critical patients, Eurofins Viracor is committed to helping medical professionals, transplant teams, reference labs and biopharmaceutical companies get results faster, when it matters most.
Eurofins Viracor is passionate about providing timely, actionable test results, never losing sight of the connection between the testing we perform and the patients our results ultimately serve.
Find out more by visiting us at www.eurofins-viracor.com/clinical
Eurofins Viracor is an equal opportunity employer.
Offices: 18000 W 99th St, Lenexa, Kansas 66219, US