Medical Director, Early Phase Clinical Development
San Francisco, California, United States · Hybrid
$300k–$330k/yr
Senior$300M raised
Medical Director, Early Phase Clinical Development Location: Thousand Oaks, CA or San Francisco, CA Reports To: Executive Director, Clinical Development The Medical Director will support the planning, execution, oversigh…
Skills: Clinical Development, Medical Monitoring, Clinical Pharmacology, Pharmacovigilance, Protocol Development
San Francisco, California, United States · On-site
$380k–$460k/yr
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We’re building the scientific intelligence platform for the physical world, to accelerate breakthroughs in semiconductors, batteries, advanced materials, aerospace, and beyond. These industries represent trillions in spe…
Latigo is seeking a highly organized and detailed oriented Clinical Trial Associate to provide operational and administrative support for Latigo-sponsored clinical trials. This position will support the Clinical Operatio…
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$300k–$330k/yr
Full-time
postgraduate degree
Posted 3d ago
~40 hrs/week
Responsibilities
The Medical Director will provide medical leadership and oversight for Phase 1 and clinical pharmacology studies, including study design and safety monitoring. They will collaborate with cross-functional teams to interpret clinical data and contribute to regulatory submissions.
Requirements
Candidates must hold an MD or equivalent medical degree and possess at least 5 years of industry experience in clinical development. Strong expertise in clinical pharmacology and experience serving as a Medical Monitor for early-phase studies are strongly preferred.
Full job description
Medical Director, Early Phase Clinical Development
Location:Thousand Oaks, CA or San Francisco, CA Reports To: Executive Director, Clinical Development
The Medical Director will support the planning, execution, oversight, and interpretation of Phase 1 and clinical pharmacology studies across the company's development programs. This role will work closely with Clinical Pharmacology, Clinical Operations, Statistics, Pharmacovigilance, and Regulatory teams to provide medical leadership for first-in-human and other early clinical studies, including SAD/MAD, food effect, thorough QT (TQT), drug-drug interaction (DDI), hepatic impairment, and renal impairment studies.
The ideal candidate has significant experience supporting and/or serving as Medical Monitor for Phase 1 and clinical pharmacology studies and is comfortable working in a fast-paced biotechnology environment where collaboration, flexibility, and efficient decision-making are essential.
Primary Responsibilities
Serve as Medical Monitor for Phase 1 and clinical pharmacology studies.
Provide medical oversight for study conduct, including review of adverse events, serious adverse events, laboratory abnormalities, and emerging safety data.
Partner closely with Clinical Pharmacology on study design, dose escalation decisions, protocol development, and interpretation of clinical pharmacology data.
Provide medical input into study protocols, informed consent forms, investigator brochures, clinical study reports, and other clinical development documents.
Respond to investigator and site medical questions in a timely manner.
Participate in Safety Review Committees and other study governance activities.
Review and interpret safety, pharmacokinetic (PK), pharmacodynamic (PD), biomarker, and other clinical data to support study decisions.
Present study results and clinical recommendations to internal teams and external stakeholders, as needed.
Contribute to regulatory submissions and responses to health authority questions.
Qualifications
MD or equivalent medical degree.
Active medical license preferred.
Minimum 5 years of industry experience in clinical development.
Experience serving as Medical Monitor for Phase 1 and clinical pharmacology studies is strongly preferred.
Demonstrated experience supporting first-in-human (FIH), SAD/MAD, food effect, TQT, DDI, hepatic impairment, renal impairment, and other clinical pharmacology studies.
Strong understanding of clinical pharmacology, drug development, GCP, and applicable regulatory requirements.
Ability to interpret PK, PD, safety, biomarker, and clinical data.
Experience in pain, neuroscience, neurology, anesthesiology, psychiatry, clinical pharmacology, or other relevant therapeutic areas preferred.
Personal Characteristics
Thrives in a fast-paced, highly collaborative environment.
Demonstrates flexibility, adaptability, and a willingness to take on new challenges.
Prioritizes efficiency, accuracy, and execution while maintaining scientific rigor.
Communicates clearly, proactively, and with a solutions-oriented mindset.
Takes ownership and delivers results in a dynamic and evolving organization.
Positioned to change the treatment paradigm of pain medicines
Industry
Biotechnology Research
Company size
51-200 employees
Headquarters
Thousand Oaks, CA
LinkedIn followers
9,910
Total funding
$300M
Latigo Biotherapeutics (Nasdaq: LTGO) is a clinical-stage biopharmaceutical company committed to developing innovative non-opioid pain medicines designed to stop the transmission of pain without the risk of addiction, with the goal to provide effective, rapid-acting pain relief. Latigo’s lead product candidate, LTG-001, is an oral Nav1.8 inhibitor designed to provide fast-acting, opioid-sparing relief for the treatment of acute pain.
How much do Science & Research jobs in San Francisco, CA pay?
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