Thousand Oaks, California, United States · On-site
$158k–$213k/yr
Senior+$29B raised
Career CategoryScientificJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious …
Skills: Oligonucleotide process development, GMP manufacturing, Technology transfer, Process chemistry, Chemical engineering
Classification: Exempt Job Family: Technicians Reports to: HHMI Member Job Description Summary: Collaborate on research projects supporting the lab's scientific objectives, with a major focus on developing and performing…
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2027 Spring Co op Neuroscience Research Cambridge MA
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Job title: Director, Respiratory Market Development, US HCP Engagement Location: Cambridge, MA About the Job We are an innovative global healthcare company, committed to transforming the lives of people with immune chall…
Thousand Oaks, California, United States · On-site
$115k–$156k/yr
Senior$29B raised
Career CategoryEngineeringJob DescriptionJoin Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious…
Skills: Process development, Technology transfer, Scale-up, Risk assessment, Process modeling
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Machine Learning Engineer (Robotics and AI Institute LLC):
Cambridge, Massachusetts, United States · On-site
$186k–$238k/yr
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Cambridge, Massachusetts, United States · Remote OK
$145k–$196k/yr
Senior+$4.5B raised
Senior Manager, Clinical Data Management The Senior Manager, Clinical Data Management will lead and contribute to data management activities in support of Alnylam studies across all stages of clinical drug development. S…
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Pioneering Medicines: Medical Director / Senior Medical Director, Clinical Development Lead
Cambridge, Massachusetts, United States · Hybrid
$215k–$335k/yr
Senior$9.1B raised
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Specialist/Sr. Specialist - Global Audits, Inspections, and QMS (AIQ)
Cambridge, Massachusetts, United States · On-site
Mid level
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San Francisco, California, United States · On-site
$116k–$170k/yr
Mid level$551M raised
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Pioneering Intelligence: Data Science Co-Op (Embedded Science Team)
Cambridge, Massachusetts, United States · On-site
$25/hr–$35/hr
Entry level$9.1B raised
What if... you could use AI to impact an entire ecosystem of life science companies? Pioneering Intelligence (PI) is a Flagship initiative focused on developing and harnessing AI/ML based platforms for innovative applica…
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$158k–$213k/yr
Full-time
postgraduate degree, bachelor degree
Retirement and Savings Plan, Group medical coverage, Dental coverage, Vision coverage, Life insurance, Disability insurance
Posted 2d ago
~40 hrs/week
Responsibilities
The Senior Principal Scientist will lead a multidisciplinary team in the development and industrialization of efficient, sustainable manufacturing processes for oligonucleotides. They will drive technology innovation, manage technology transfers to GMP facilities, and provide technical guidance to support regulatory filings.
Requirements
Candidates must hold a Doctorate degree (PhD, PharmD, or MD) with at least 3 years of scientific experience, or a Master's degree with 6 years, or a Bachelor's degree with 8 years. Preferred qualifications include 6+ years of pharmaceutical industry experience with specific expertise in oligonucleotide process development and GMP manufacturing.
Full job description
Career Category
Scientific
Job Description
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Process Development Senior Principal Scientist Bioconjugates
What you will do
Let’s do this. Let’s change the world. In this vital role you will Amgen’s DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's exciting portfolio of synthetic and hybrid assets. Process chemists within our team to apply their training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development.
Amgen is currently seeking a talented Senior Principal Scientist who will lead a multidisciplinary team of chemists and chemical engineers in the development of efficient and sustainable manufacturing processes, drive capacity expansion projects, and lead technology transfers for oligonucleotides. The candidate will drive technology innovation, provide technical expertise, and develop and mentor staff within the organization. The successful candidate for this role will be a people-centered leader with deep expertise in oligonucleotide process development and industrialization with a proven track record of scientific innovation and leadership within the pharmaceutical industry. The role will be located at either our Thousand Oaks, California or Cambridge, Massachusetts campus.
Lead a multidisciplinary project team in the development of sustainable and cost-effective processes for oligonucleotide manufacturing.
Work with cross-functional teams to develop strategies and implementation plans to expand production capacity and improve yield.
Drive oligonucleotide technology innovation
Support cGMP manufacturing and technology transfer to GMP production facilities
Develop strategies to ensure process performance through process understanding, modeling and characterization
Guide successful completion of project deliverables and ensure timelines are met
Work cross-functionally to deliver regulatory documents and support regulatory filings
Serve as a technical expert and keep current in the field of bioconjugate manufacturing
Coach and provide career and scientific / technical advice to colleagues within the organization
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.
Basic Qualifications:
Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of Scientific experience OR
Master’s degree and 6 years of Scientific experience OR
Bachelor’s degree and 8 years of Scientific experience
Preferred Qualifications:
Doctoral degree and 6+ years in the pharmaceutical industry with expertise in oligonucleotide process development
GMP manufacturing and technology transfer to CMOs
Demonstrated functional representation on a CMC or PDT team
Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
People-centered leadership skills in building strong teams through mutual trust and respect and exhibits Amgen leadership attributes of inspire, accelerate, integrate, and adapt
Proven track record of publications, patents and presentations
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.
careers.amgen.com
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Sponsorship
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. We helped establish the biotechnology industry, and we remain on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today. Our investment in research and development has yielded a robust pipeline that builds on our existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases.
Amgen is one of 30 companies comprising the Dow Jones Industrial Average®, and part of the Nasdaq-100 Index®. In 2024, Amgen was named one of the “World’s Most Innovative Companies” by Fast Company and one of “America’s Best Large Employers” by Forbes.
For more information, visit Amgen.com and follow us on X, LinkedIn, Instagram, TikTok, YouTube and Threads.
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Special Advisory: Please be cautious of scam recruitment offers claiming to be from Amgen. Such scams may come from various sources, including fake websites and/or unsolicited emails and seek to obtain personal data or payment from victims by offering jobs that do not exist. Please be advised that Amgen would never ask for payment to progress a job application. When in doubt, please check to see if the position in question is posted on this website before applying. Additionally, please report any suspicious recruiting activity to https://complaint.ic3.gov/ and thank you for your assistance.
Offices: One Amgen Center Drive, Thousand Oaks, CA 91320, US · 1120 Veterans Blvd, South San Francisco, CA 94080, US · 34 Commerce Way, Woburn, MA 01801, US · Avenida Calle 100 7-81, Bogota, Bogota, D.C. 110221, CO · Minervum 7061, Breda, North Brabant 4817 ZK, NL
BiologicsHuman therapeuticsand Development of novel productsHuman ResourcesHealth DiagnosticsHealth CareProfessional ServicesBiotechnologyManufacturingPharmaceutical
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